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Chlordiazepoxide (Chlordiazepoxide Hydrochloride) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The necessity of discontinuing therapy because of undesirable effects has been rare. Drowsiness, ataxia and confusion have been reported in some patients — particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.

Other adverse reactions reported during therapy include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extrapyramidal symptoms, as well as increased and decreased libido. Such side effects have been infrequent, and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after chlordiazepoxide HCl treatment.

Blood dyscrasias (including agranulocytosis), jaundice and hepatic dysfunction have occasionally been reported during therapy. When chlordiazepoxide HCl treatment is protracted, periodic blood counts and liver function tests are advisable.



REPORTS OF SUSPECTED CHLORDIAZEPOXIDE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Chlordiazepoxide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Chlordiazepoxide side effects / adverse reactions in 27 year old female

Reported by a physician from United States on 2011-10-24

Patient: 27 year old female weighing 58.5 kg (128.7 pounds)

Reactions: Contusion, Hepatic Necrosis, Pulmonary Congestion, Accidental Death, Pulmonary Oedema, Toxicity TO Various Agents

Adverse event resulted in: death

Suspect drug(s):
Carisoprodol
    Indication: Product Used FOR Unknown Indication

Meprobamate
    Indication: Product Used FOR Unknown Indication

Benzodiazepines (Unknown)
    Indication: Product Used FOR Unknown Indication

Xyrem
    Dosage: 5 gm (2.5 gm, 2 in 1 d), oral; 13.5 gm (6.75 gm, 2 in 1 d), oral
    Administration route: Oral
    Indication: Insomnia
    Start date: 2011-05-10
    End date: 2011-07-01

Xyrem
    Dosage: 5 gm (2.5 gm, 2 in 1 d), oral; 13.5 gm (6.75 gm, 2 in 1 d), oral
    Administration route: Oral
    Indication: Insomnia
    Start date: 2005-11-10

Nicotine
    Indication: Product Used FOR Unknown Indication

Ibuprofen
    Indication: Product Used FOR Unknown Indication

Chlordiazepoxide
    Indication: Product Used FOR Unknown Indication

Nordiazepam (Unknown)
    Indication: Product Used FOR Unknown Indication

Opiates (Unknown)
    Indication: Product Used FOR Unknown Indication

Acetaminophen
    Indication: Product Used FOR Unknown Indication

Oxazepam
    Indication: Product Used FOR Unknown Indication



Possible Chlordiazepoxide side effects / adverse reactions in 30 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-04

Patient: 30 year old female

Reactions: Dyspnoea, Intentional Overdose, Altered State of Consciousness

Adverse event resulted in: hospitalization

Suspect drug(s):
Quazepam
    Administration route: Oral
    Indication: Depression

Clonazepam
    Administration route: Oral
    Indication: Depression

Tandospirone Citrate
    Administration route: Oral
    Indication: Depression

Etizolam
    Administration route: Oral
    Indication: Depression

Bromazepam
    Administration route: Oral
    Indication: Depression

Diazepam
    Administration route: Oral
    Indication: Depression

Chlordiazepoxide
    Administration route: Oral
    Indication: Depression

Medazepam
    Indication: Depression

Pentobarbital CAP
    Administration route: Oral
    Indication: Depression

Flunitrazepam
    Administration route: Oral
    Indication: Depression

Clomipramine Hydrochloride
    Administration route: Oral
    Indication: Depression

Clotiazepam
    Administration route: Oral

Phenobarbital TAB
    Administration route: Oral
    Indication: Depression

Oxazolam
    Administration route: Oral
    Indication: Depression

Cloxazolam
    Administration route: Oral
    Indication: Depression

Estazolam
    Administration route: Oral
    Indication: Depression

Mexazolam
    Administration route: Oral
    Indication: Depression

Alprazolam
    Administration route: Oral

Flutazolam
    Administration route: Oral
    Indication: Depression



Possible Chlordiazepoxide side effects / adverse reactions in 30 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-15

Patient: 30 year old female

Reactions: Dyspnoea, Intentional Overdose, Altered State of Consciousness

Adverse event resulted in: hospitalization

Suspect drug(s):
Etizolam
    Administration route: Oral
    Indication: Depression

Cloxazolam
    Administration route: Oral
    Indication: Depression

Tandospirone Citrate
    Administration route: Oral
    Indication: Depression

Phenobarbital TAB
    Administration route: Oral
    Indication: Depression

Phenobarbital TAB
    Administration route: Oral
    Indication: Depression

Estazolam
    Administration route: Oral
    Indication: Depression

Flunitrazepam
    Administration route: Oral
    Indication: Depression

Quazepam
    Administration route: Oral
    Indication: Depression

Oxazolam
    Administration route: Oral
    Indication: Depression

Clonazepam
    Administration route: Oral
    Indication: Depression

Bromazepam
    Administration route: Oral
    Indication: Depression

Diazepam
    Administration route: Oral
    Indication: Depression

Flutazolam
    Administration route: Oral
    Indication: Depression

Clotiazepam
    Administration route: Oral
    Indication: Depression

Alprazolam
    Administration route: Oral
    Indication: Depression

Clomipramine HCL
    Administration route: Oral
    Indication: Depression

Chlordiazepoxide
    Administration route: Oral
    Indication: Depression

Medazepam
    Indication: Depression

Mexazolam
    Administration route: Oral
    Indication: Depression



See index of all Chlordiazepoxide side effect reports >>

Drug label data at the top of this Page last updated: 2012-08-15

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