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Chlorphen Mal Pseudoeph (Chlorpheniramine Maleate / Pseudoephedrine Hydrochloride) - Drug Interactions, Contraindications, Overdosage, etc



CHLORPHEN MAL PSEUDOEPH drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.


The definition of overdose has not been established for Chlorphen Mal/Pseudoeph HCl 0.8/9 mg Drops. Individuals may exhibit overdose signs and symptoms to a range of administered doses.

Signs and Symptoms
Acute overdosage with antihistamines results primarily in central nervous system effects. In the small child, predominant symptoms are excitation, hallucination, ataxia, incoordination, tremors, flushed face and fever. Convulsions, fixed and dilated pupils, coma and death may occur in severe cases.

Acute overdosage with sympathomimetics include central nervous system effects such as restlessness, dizziness, tremor, hyperactive reflexes, talkativeness, irritability and insomnia. Cardiovascular and renal effects include difficulty in micturition, headache, flushing, palpitation, cardiac arrhythmia, hypertension with subsequent hypotension and circulatory collapse.

Gastrointestinal effects include dry mouth, metallic taste, anorexia, nausea, vomiting, diarrhea and abdominal cramps.

In the event of overdose, induce emesis if patient is alert and is seen prior to 6 hours following ingestion. Gastric lavage may be carried out. Precautions against aspiration must be taken, especially in infants and small children.

For CNS hyperactivity or convulsive seizures, intravenous short-acting barbiturates may be indicated. Hypertensive responses and/or tachycardia should be treated appropriately. Oxygen, intravenous fluids and other supportive measures should be used as indicated.


This product is contraindicated in patients with hypersensitivity or idiosyncrasy to any of its ingredients, to adrenergic agents, or to other drugs of similar chemical structures.

Do not use in newborn infants, premature infants, in nursing mothers, in patients with severe hypertension, severe coronary artery disease, ischemic heart disease, or in those receiving monoamine oxidase (MAO) inhibitors.

This product is contraindicated in patients with narrow-angle glaucoma, urinary retention, peptic ulcer, and during an asthma attack.

Antihistamines should not be used to treat lower respiratory tract conditions including asthma.

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