DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Claripel Cream (Hydroquinone) - Summary



Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and suppression of other melanocyte metabolic processes.

Claripel Cream is indicated for the gradual treatment of ultraviolet induced dyschromia and discoloration resulting from the use of oral contraceptives, pregnancy, hormone replacement therapy, or skin trauma.

See all Claripel Cream indications & dosage >>


Published Studies Related to Claripel Cream (Hydroquinone)

A randomized, double-blind, placebo-controlled clinical trial on the efficacy and safety of 3% Rumex occidentalis cream versus 4% hydroquinone cream in the treatment of melasma among Filipinos. [2014]
melasma... CONCLUSIONS: Rumex occidentalis 3% cream is a safe and effective skin-lightening

Further enhancement of facial appearance with a hydroquinone skin care system plus tretinoin in patients previously treated with botulinum toxin Type A. [2011.07]
BACKGROUND: A hydroquinone (HQ) skin care system has been designed for use in conjunction with nonsurgical procedures. OBJECTIVE: The authors evaluate the efficacy of this system plus tretinoin for improving facial appearance in comparison to a standard skin care regimen in users of botulinum toxin Type A (BoNT-A)... CONCLUSIONS: Adjunctive use of the HQ system plus tretinoin can further enhance the improvements in facial appearance attained with BoNT-A. Applying the HQ system plus tretinoin offers multiple clinical benefits over standard skin care, including significantly greater improvements in fine lines/wrinkles and hyperpigmentation.

Evaluation of a kojic acid, emblica extract, and glycolic acid formulation compared with hydroquinone 4% for skin lightening. [2010.09]
Hydroquinone has been the standard prescription agent for skin lightening; however, its use recently has become controversial. Hydroquinone is banned in Europe and parts of Asia because of potential long-term consequences, including carcinogenesis when orally consumed... Thus this novel skin lightening preparation is an alternative to hydroquinone 4% for participants with mild to moderate facial dyschromia.

Treating photodamage of the decolletage area with a novel copper zinc malonate complex plus hydroquinone and tretinoin. [2010.03]
There has been a proliferation of treatments for facial rejuvenation but, curiously, the use of such treatments on other areas of the body has not been widely investigated. The clinical effects of treating photodamaged skin of the neck and anterior chest area (decolletage) with a proprietary copper zinc malonate lotion and a proprietary 4% hydroquinone cream (twice daily), plus tretinoin cream (once daily), were evaluated in 42 females in a 24-week investigator-blind randomized study...

Benefits of using a hydroquinone/tretinoin skin care system in patients undergoing intense pulsed light therapy for photorejuvenation: a placebo-controlled study. [2009.09]
A hydroquinone/tretinoin (HQ/tret) skin care system designed for use with non-surgical facial rejuvenation procedures has recently become available. In this observer-masked study, 36 patients with moderate-to-severe wrinkling of the skin around the eyes and lips were randomly assigned to use either the 4% hydroquinone/0.05% tretinoin skin care system or placebo products, each day for 90 days...

more studies >>

Clinical Trials Related to Claripel Cream (Hydroquinone)

Azelaic Acid Versus Hydroquinone in Melasma [Recruiting]

Clinical Trial of Hydroquinone Versus Miconazol in Melasma [Recruiting]
Melasma is an acquired discoloration of the skin characterized by brown colour changes commonly on the face. The duration of this double-blind clinical trial will be 12 weeks. The control group will receive treatment with topical Hydroquinone (4%), and the other group topical miconazole. Miconazol has antimelanotic properties and can be used as treatment for melasma patients. The estimated number of subjects to be recruited and randomized for the study is at least 30. The purpose of this study is determine if there is a difference in the effectiveness of these two agents. Melasma Area and Severity Index (MASI) score will be assessed at the beginning of the study and at weeks 4, 8, and 12. Photographs, colorimetry and histological assessment will be also evaluated. Occurrence of adverse effects will also be recorded.

Efficacy and Safety of a 4% Hydroquinone Cream (Melanoderm 4%) for the Treatment of Melasma: a Randomized Controlled Split-face Study [Completed]
To assess the ability of a new 4% Hydroquinone formulation (Melanoderm 4% Crema) to reduce melasma on the face, using a split-face randomization design, evaluating the MASI Score from baseline to week 4 and week 8, in both half-faces receiving active treatment vs. placebo. To assess the tolerance of a new 4% Hydroquinone formulation (Melanoderm 4% Crema) on the face. To assess patients' satisfaction regarding Melanoderm 4% Crema after 8 weeks.

Efficacy and Safety of ARTRA (Glucosamine Plus Chondroitin Sulfate Combination) in Treatment of Chronic Low Back Pain [Completed]
To study the safety and efficacy of ARTRA (glucosamine chondroitin sulfate) in the treatment of non-specific low-back pain of lumbosacral localization in ambulatory care.

Effects of Low-dose Complex B-vitamins on Homocysteine and Framingham Risk Score Among Chinese Elderly [Completed]
The purpose of this study is to evaluate whether low dose complex B-vitamins (folic acid,vitamin B6 and vitamin B12) can lower the risk of developing hyperhomocysteinemia in an apparently healthy population with low folate/B12 and high Hcy status.

more trials >>


Based on a total of 11 ratings/reviews, Claripel Cream has an overall score of 6.55. The effectiveness score is 7.45 and the side effect score is 7.45. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Claripel Cream review by 32 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   hyperpigmatation
Dosage & duration:   fluo. acet. 0.01%, hydro4%, tret 0.5% (dosage frequency: one 20 gram tube every eight weeks) for the period of once per night
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   hydeoquione mitigated uneven tone of face as well as freckles. It additionally left the skin with a taught texture. My skin seemd to look 10 years younger
Side effects:   I wore 60 SPF everyday even in the winter to avoid any sun damage. I did not experience any side affects.
Comments:   I was seen by my doctor and he thought the medication would be the best route to take for my condition. I was told to put it on my face three time a week at night. However- I used it every night


Claripel Cream review by 23 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   pigmentation
Dosage & duration:   2% (dosage frequency: 1x daily) for the period of 4 months
Other conditions:   Redness
Other drugs taken:   Vitamin C
Reported Results
Benefits:   Minimized pigmentation if not absolved them altogether. Good results for both hypo- and hyper- pigmentation.
Side effects:   So far none, however there could be future side effects. I've read recent studies that have come out stating the carcinogenic nature of this drug. I would not advise anyone else to use this drug since there are natural alternatives.
Comments:   Placed the cream daily on the pigmented lesions for 4 months. I have stopped using this drug altogether after reading the reports.


Claripel Cream review by 43 year old female patient

Overall rating:  
Effectiveness:   Ineffective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   hyperpigmentation
Dosage & duration:   4% cream (dosage frequency: two a day) for the period of four weeks
Other conditions:   some acne
Other drugs taken:   none
Reported Results
Benefits:   I did not have any benefits by using hydroquinone
Side effects:   I had some light hyperpigmentations, and hydroquinone made my hyperpigmentation darker.
Comments:   My dermatologist prescribed hydroquinone 4% cream to helped me with a light hyperpigmentation problem. However, hydroquinone did not work at all. I had the opposite effect. My hyperpigmentation became darker.

See all Claripel Cream reviews / ratings >>

Page last updated: 2015-08-10

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017