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Claripel Cream (Hydroquinone) - Description and Clinical Pharmacology



Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C6H6O2; molecular weight 110.1. The structural formula is:


ACTIVE INGREDIENT:    Hydroquinone USP 4%

OTHER INGREDIENTS: Avobenzone, Ceteareth-20, Cetostearyl Alcohol, Citric Acid, Diethylaminoethyl Stearate, Dimethicone, Edetate Disodium, Glyceryl Dilaurate, Glyceryl Monostearate, Glyceryl Stearate, PEG-100 Stearate, Hydroxyethyl Cellulose, Methylparaben, Octyldodecyl Stearoyl Stearate, Octinoxate, Oxybenzone, Polysorbate 80, Propylene Glycol, Propyl Gallate, Propylparaben, Purified Water, Quaternium-26, Sodium Metabisulfite, Sodium PCA, Squalane, Ubiquinone, Stearyl Alcohol, Water, Glycerin, Rumex occidentalis extract.


Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa)1 and suppression of other melanocyte metabolic processes. 2 Exposure to sunlight or ultraviolet light will cause repigmentation which may be prevented by the broad spectrum sunscreen agents contained in Claripel Cream.3

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