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Clinac (Benzoyl Peroxide Topical) - Description and Clinical Pharmacology

 
 



DESCRIPTION

Clinac® BPO 7 (benzoyl peroxide) is a topical preparation containing 7% benzoyl peroxide as the active ingredient in a gel vehicle containing purified water, propylene glycol, Acrysorb™ (brand of acrylates copolymer), PEG-400, carbomer 940, disodium EDTA, and sodium hydroxide.

The chemical structure for the active ingredient is:

CLINICAL PHARMACOLOGY

The exact method of action of benzoyl peroxide in acne vulgaris is not known. Benzoyl peroxide is an antibacterial agent with demonstrated activity against Propionibacterium acnes. This action combined with the mild keratolytic effect of benzoyl peroxide is believed to be responsible for its usefulness in acne.

Little is known about the percutaneous penetration, metabolism and excretion of benzoyl peroxide. Benzoyl peroxide is absorbed by the skin where it is metabolized to benzoic acid and excreted as benzoate in the urine. There is no evidence of systemic toxicity caused by benzoyl peroxide in humans.

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