ADVERSE REACTIONS
Serious adverse reactions associated with codeine are respiratory depression and, to a lesser degree, circulatory depression, respiratory arrest, shock, and cardiac arrest.
The most frequently observed adverse reactions with codeine administration include drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, sweating, and constipation.
Other adverse reactions include allergic reactions, euphoria, dysphoria, abdominal pain, and pruritis.
Other less frequently observed adverse reactions expected from opioid analgesics, including codeine sulfate, include:
Cardiovascular system: faintness, flushing, hypotension, palpitations, syncope
Digestive System: abdominal cramps, anorexia, diarrhea, dry mouth, gastrointestinal distress, pancreatitis
Nervous system: anxiety, drowsiness, fatigue, headache, insomnia, nervousness, shakiness, somnolence, vertigo, visual disturbances, weakness
Skin and Appendages: rash, sweating, urticaria
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REPORTS OF SUSPECTED CODEINE SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Codeine. The information is not vetted and should not be considered as verified clinical evidence.
Possible Codeine side effects / adverse reactions in 28 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-03
Patient: 28 year old female
Reactions: Intentional Overdose, Major Depression, Loss of Consciousness
Adverse event resulted in: hospitalization
Suspect drug(s):
Codeine
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Acetaminophen
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Citalopram
Dosage: unk
Indication: Product Used FOR Unknown Indication
Possible Codeine side effects / adverse reactions in 19 year old male
Reported by a health professional (non-physician/pharmacist) from Denmark on 2011-11-04
Patient: 19 year old male
Reactions: Toxicity TO Various Agents
Adverse event resulted in: death
Suspect drug(s):
Oxazepam
Diazepam
Nordazepam
Oxycodone HCL
Cocaine
Codeine
Mirtazapine
Amphetamine Sulfate
Morphine Sulfate
Tetrahydrocannabinol
Possible Codeine side effects / adverse reactions in 70 year old female
Reported by a physician from Czech Republic on 2011-11-08
Patient: 70 year old female
Reactions: Expired Drug Administered, Serotonin Syndrome
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Citalopram
Citalopram Hydrobromide
Sertraline Hydrochloride
DHC
Tramadol HCL
Morphine Sulfate
Codeine
Zoloft
Other drugs received by patient: Calcium Carbonate/colecalciferol/minerals NOS; Theophylline; Tribenoside; Budesonide/formoterol Fumarate; Cetirizine; Atorvastatin; Telmisartan; Nitrendipine; Rilmenidine; Metoprolol
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