NEWS HIGHLIGHTSMedia Articles Related to Collagenase Santyl (Collagenase)
Burns (First Aid)
Source: MedicineNet Hyperkalemia Specialty [2016.08.25]
Title: Burns (First Aid)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM
Sun-Damaged Skin: Pictures of Sun Spots, Wrinkles, Sunburns
Source: MedicineNet Actinic Keratosis Specialty [2016.06.06]
Title: Sun-Damaged Skin: Pictures of Sun Spots, Wrinkles, Sunburns
Category: Slideshows
Created: 6/11/2008 12:00:00 AM
Last Editorial Review: 6/6/2016 12:00:00 AM
Published Studies Related to Collagenase Santyl (Collagenase)
Clinical efficacy, safety and tolerability of collagenase clostridium
histolyticum for the treatment of peyronie disease in 2 large double-blind,
randomized, placebo controlled phase 3 studies. [2013]
score from baseline to 52 weeks... CONCLUSIONS: IMPRESS I and II support the clinical efficacy and safety of
Injectable collagenase Clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease. [2010.12]
PURPOSE: The Collagenase Option for the Reduction of Dupuytren's (CORD) II study investigated the efficacy and safety of injectable Xiaflex (collagenase clostridium histolyticum), in patients with Dupuytren's contracture... CONCLUSIONS: Collagenase clostridium histolyticum is the first Food and Drug Administration-approved, nonsurgical treatment option for adult Dupuytren's contracture patients with a palpable cord that is highly effective and well tolerated. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic I. Copyright (c) 2010. Published by Elsevier Inc.
Collagenase injection as nonsurgical treatment of Dupuytren's disease: 8-year follow-up. [2010.04]
PURPOSE: Collagenase has been investigated in phase II and phase III clinical trials for the treatment of Dupuytren's disease. The purpose of this study is to report 8-year follow-up results in a subset of patients who had collagenase injection for the treatment of Dupuytren's contracture... CONCLUSIONS: Enzymatic fasciotomy is safe and efficacious, with initial response to injection resulting in reduction of joint contracture to within 0 degrees -5 degrees of normal in 72 out of 80 patients. Initial evaluation of long-term recurrence rates suggests disease recurrence or progression in 4 out of 6 patients with MCP contractures and 2 patients with PIP contractures; however, recurrence was generally less severe than the initial contracture in the MCP group. In addition, patient satisfaction was high.
Percutaneous treatment of non-contained lumbar disc herniation by injection of oxygen-ozone combined with collagenase. [2009.12]
PURPOSE: To evaluate the therapeutic results of oxygen-ozone combined collagenase injection for the treatment of lumbar disc herniation compared to the surgery. And to explore the role of this minimally invasive treatment as an alternative to disc surgery... CONCLUSIONS: The combination of the oxygen-ozone with collagenase shows significant reductions in pain and improvements in function at 3 and 12 months, it can be considered as an option for the treatment of non-contained lumbar disc herniation instead of surgery.
Effect of collagenase and esterase on resin-dentin interface: a comparative study between a total-etch adhesive and a self-etch adhesive. [2009.10]
PURPOSE: To examine the effects of collagenase and esterase activity on the microtensile bond strength and nanoleakage at the resin-dentin interfaces of two adhesive systems: a total-etch adhesive (Single Bond 2: SB) and a self-etch adhesive (Clearfil SE Bond: SE)...
Clinical Trials Related to Collagenase Santyl (Collagenase)
Collagenase in the Treatment of Zone II Flexor Tendon Adhesions in the Hand [Completed]
The purpose of this study is to dissolve flexor tendon adhesions associated with failed
tendon repair surgery.
Injectable Collagenase For Burns' Associated Contracture [Not yet recruiting]
A pilot experiment to test the efficiency of the enzyme Collagenase in treating contractures
which result's from burn's healing process.
So far, treatment of choice in patients with burn's created movement limiting contractures,
concentrated around supportive care. Patients were referred to surgical intervention only if
necessary. Treatment by injecting an external enzyme is avant-garde and hasn't been done
under such conditions.
This study might introduce a new kind of treatment, which can be done in ambulatory
environment .This type of treatment might significantly improve patients' function and
quality of life, with no need for a surgical intervention.
Effectiveness Study of Santyl Ointment to Treat Pressure Ulcers [Terminated]
Researchers at LSUHSC-S hope to learn the effects of the combination of a medication and a
device which by themselves are effective for the treatment of wounds.
You are being asked to take part in this study because you have a wound on your body which
has not responded to standard treatments.
The researchers will be studying whether the combination of two treatments will make wounds
heal faster. For those in study, the investigators will treat them with a vacuum device on
their wound. Also, some of the people in the study will receive a special ointment and
researchers will use special tests to determine if the two treatments together are working
better than just one treatment alone.
MEDIHONEY® Gel Versus Collagenase for Wound Debridement [Recruiting]
The purpose of this study is to compare how well two products, Active Leptospermum Honey
(ALH) (MEDIHONEY® Gel) and Collagenase (Santyl®), in removing the nonviable (non living)
tissue.
Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease [Withdrawn]
Dupuytren's disease results in deformity of the hand and this can lead to trouble with daily
activities. Treatment traditionally involves cutting out diseased tissue, however this can
cause damage to important structures in the hand and results in large scars.
Needle aponeurotomy and collagenase injections are newer treatments that are thought to be
safer. These treatments allow quicker return to function. One drawback is that Dupuytren's
deformity may return more quickly than when all diseased tissue is surgically cut out.
This research study is designed to compare the effectiveness of needle aponeurotomy and
collagenase injection for Dupuytren's disease. This study will determine which procedure
gives the best results- either needle aponeurotomy, collagenase injection, or both
procedures in combination. Participants will be evaluated to see how they do in the long
term.
|
