NEWS HIGHLIGHTS
Published Studies Related to Cordran SP (Flurandrenolide Topical)
Comparative efficacy of once-daily flurandrenolide tape versus twice-daily diflorasone diacetate ointment in the treatment of psoriasis. [1998.02]
BACKGROUND: Flurandrenolide tape has recently been listed as a group I topical corticosteroid. There are no studies that compare this product to group I ointments in the treatment of steroid-responsive dermatoses. OBJECTIVE: Our purpose was to determine the relative efficacy of flurandrenolide (4 microg/cm2) tape versus 0.05% diflorasone diacetate ointment in plaque psoriasis... CONCLUSION: The efficacy of flurandrenolide tape in the treatment of psoriatic plaques surpasses that of diflorasone diacetate ointment.
Transmittance properties of flurandrenolide tape for psoriasis: helpful adjunct to phototherapy. [2000.10]
BACKGROUND: Flurandrenolide tape is a valuable agent in the treatment of lichen simplex chronicus and in psoriasis. The corticosteroid is helpful for reducing the symptoms and induration of the lichen simplex chronicus lesion, and occlusion of the lesion with the tape reduces the patient's opportunity to rub and scratch the affected area. OBJECTIVES: The purpose of this study was to determine to what extent flurandrenolide tape may block ultraviolet (UV) light and interfere with phototherapy of psoriasis... CONCLUSION: Although flurandrenolide tape may be left in place during PUVA therapy, adjustment of UV dose or removal of the tape is probably needed during UVB phototherapy.
Clinical Trials Related to Cordran SP (Flurandrenolide Topical)
Haelan and Nutrition in Cancer Patients [Terminated]
Primary:
- To determine if treatment with Haelan (fermented soy product) can decrease the severity
of poor appetite measured using a visual analog scale (VAS) of 0 to 100 mm (0 mm =
best, 100 mm = worst) at week 4 +/- 5 days.
- To determine if treatment with Haelan can decrease the severity of nausea, fatigue, and
improve patients' overall sense of well being measured using a VAS of 0 to 100 mm (0 mm
= best, 100 mm = worst) at week 4 +/- 5 days.
- To determine if treatment with Haelan can increase patient's calorie intake, albumin,
pre-albumin, anthropometric measure, lean body mass (measured by bio-impedence
analysis), and weight at week 4+/- 5 days.
- To determine if treatment with Haelan can decrease patient's Functional assessment of
anorexia/cachexia therapy subscales or (FAACT) and the Functional Assessment of Chronic
Illness Therapy with fatigue subscales (FACIT-F) at week 4+/- 5 days.
- To assess the feasibility of accrual, and adherence to the Haelan consumption.
Secondary:
- Determine the plasma isoflavone activity, 12-MTA and 13-MTA of these patients.
- Correlate the biologic modulation of peripheral blood lymphocyte NF-kB by Haelan with
primary outcome in these patients.
- To determine if treatment with Haelan can increase patient's functional status at week
4+/- 5 days.
Steroid Impregnated Tape in the Treatment of Over-granulating Peritoneal Dialysis Exit Sites [Recruiting]
Kidney failure is a devastating illness requiring treatment with dialysis or transplantation
to preserve life. Individuals unable to have transplants are managed by peritoneal dialysis
(PD)or haemodialysis (HD). PD involves the placement of a soft, flexible plastic tube
(catheter) into the abdomen, allowing dialysis fluid to be drained in and out of the
peritoneal cavity. This catheter exits from a hole in the abdomen and occasionally patients
can have complications at this exit site. One possible complication is over-granulation.
Over-granulation occurs as the wound attempts to heal and the skin around the exit site
becomes red,'wet','bumpy' and stands 'proud' of the surrounding skin. An over-granulating
exit site can lead to discomfort, pain, bleeding and harbour infection. More serious
complications include dialysis failure, sepsis and death. There are several ways to treat
over-granulation but there is limited research evidence to demonstrate which treatment is
best. The study aims to compare current standard treatment which involves the application of
silver nitrate by qualified nursing staff to chemically burn the tissue away, with an
alternative treatment which involves the application of steroid impregnated tape to the area
of over-granulating tissue by the patient themselves.
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