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Corgard (Nadolol / Bendroflumethiazide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Most adverse effects have been mild and transient and have rarely required withdrawal of therapy.

Cardiovascular

Bradycardia with heart rates of less than 60 beats per minute occurs commonly, and heart rates below 40 beats per minute and/or symptomatic bradycardia were seen in about 2 of 100 patients. Symptoms of peripheral vascular insufficiency, usually of the Raynaud type, have occurred in approximately 2 of 100 patients. Cardiac failure, hypotension, and rhythm/conduction disturbances have each occurred in about 1 of 100 patients. Single instances of first degree and third degree heart block have been reported; intensification of AV block is a known effect of beta-blockers (see also CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS).

Central Nervous System

Dizziness or fatigue has been reported in approximately 2 of 100 patients; paresthesias, sedation, and change in behavior have each been reported in approximately 6 of 1000 patients.

Respiratory

Bronchospasm has been reported in approximately 1 of 1000 patients (see CONTRAINDICATIONS and WARNINGS).

Gastrointestinal

Nausea, diarrhea, abdominal discomfort, constipation, vomiting, indigestion, anorexia, bloating, and flatulence have been reported in 1 to 5 of 1000 patients.

Miscellaneous

Each of the following has been reported in 1 to 5 of 1000 patients: rash; pruritus; headache; dry mouth, eyes, or skin; impotence or decreased libido; facial swelling; weight gain; slurred speech; cough; nasal stuffiness; sweating; tinnitus; blurred vision. Reversible alopecia has been reported infrequently.

The following adverse reactions have been reported in patients taking nadolol and/or other beta-adrenergic blocking agents, but no causal relationship to nadolol has been established.

Central Nervous System

Reversible mental depression progressing to catatonia; visual disturbances; hallucinations; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability with slightly clouded sensorium, and decreased performance on neuropsychometrics.

Gastrointestinal

Mesenteric arterial thrombosis; ischemic colitis; elevated liver enzymes.

Hematologic

Agranulocytosis; thrombocytopenic or nonthrombocytopenic purpura.

Allergic

Fever combined with aching and sore throat; laryngospasm; respiratory distress.

Miscellaneous

Pemphigoid rash; hypertensive reaction in patients with pheochromocytoma; sleep disturbances; Peyronie's disease.

The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with nadolol.



REPORTS OF SUSPECTED CORGARD SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Corgard. The information is not vetted and should not be considered as verified clinical evidence.

Possible Corgard side effects / adverse reactions in 61 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-15

Patient: 61 year old male

Reactions: Dyspnoea, Injection Site Haemorrhage, Rales, Oedema, Thrombocytopenia, Leukopenia, Haematoma

Adverse event resulted in: hospitalization

Suspect drug(s):
Plavix
    Dosage: 75 mg, 1x/day

Lasix
    Dosage: 80 mg, 1x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-03-12
    End date: 2011-03-24

Adancor
    Dosage: 40 mg, 1x/day

Enalapril Maleate
    Dosage: 1 df, 1x/day

Repaglinide
    Dosage: 3 mg, 1x/day

Allopurinol
    Dosage: 300 mg, 1x/day

Vitamin B Complex TAB
    Dosage: unk

Corgard
    Dosage: 80 mg, 2x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-03-12

Lasix
    Dosage: 40 mg, 1x/day
    Administration route: Oral
    Start date: 2011-03-01
    End date: 2011-03-31

Atorvastatin Calcium
    Dosage: 20 mg, 1x/day

Micardis HCT
    Dosage: 1 df, 1x/day

Insulin
    Dosage: unk



Possible Corgard side effects / adverse reactions in 61 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-15

Patient: 61 year old male

Reactions: Dyspnoea, Injection Site Haemorrhage, Rales, Oedema, Thrombocytopenia, Leukopenia, Haematoma

Adverse event resulted in: hospitalization

Suspect drug(s):
Adancor
    Dosage: 40 mg, 1x/day

Micardis HCT
    Dosage: 1 df, 1x/day

Corgard
    Dosage: 80 mg, 2x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-03-12

Enalapril Maleate
    Dosage: 1 df, 1x/day

Vitamin B Complex TAB
    Dosage: unk

Repaglinide
    Dosage: 3 mg, 1x/day

Lasix
    Dosage: 80 mg, 1x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-03-12
    End date: 2011-03-24

Atorvastatin Calcium
    Dosage: 20 mg, 1x/day

Allopurinol
    Dosage: 300 mg, 1x/day

Insulin
    Dosage: unk

Plavix
    Dosage: 75 mg, 1x/day



Possible Corgard side effects / adverse reactions in 61 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-16

Patient: 61 year old male

Reactions: Dyspnoea, Injection Site Haemorrhage, Rales, Oedema, Thrombocytopenia, Haematoma, Leukopenia

Adverse event resulted in: hospitalization

Suspect drug(s):
Plavix
    Dosage: 75 mg, 1x/day

Enalapril Maleate
    Dosage: 1 df, 1x/day

Allopurinol
    Dosage: 300 mg, 1x/day

Corgard
    Dosage: 80 mg, 2x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-03-12

Adancor
    Dosage: 40 mg, 1x/day

Insulin
    Dosage: unk

Lasix
    Dosage: 80 mg, 1x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-03-12
    End date: 2011-03-24

Repaglinide
    Dosage: 3 mg, 1x/day

Micardis HCT
    Dosage: 1 df, 1x/day

Vitamin B Complex TAB
    Dosage: unk

Atorvastatin Calcium
    Dosage: 20 mg, 1x/day



See index of all Corgard side effect reports >>

Drug label data at the top of this Page last updated: 2013-12-09

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