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Dapsone (Dapsone) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS



In addition to the warnings listed above, the following syndromes and serious reactions have been reported in patients on Dapsone.

Hematologic Effects: Dose-related hemolysis is the most common adverse effect and is seen in patients with or without G6PD deficiency. Almost all patients demonstrate the inter-related changes of a loss of 1-2g of hemoglobin, an increase in the reticulocytes (2-12%), a shortened red cell life span and a rise in methemoglobin. G6PD deficient patients have greater responses.

Nervous System Effects: Peripheral neuropathy is a definite but unusual complication of Dapsone therapy in non-leprosy patients. Motor loss is predominant. If muscle weakness appears, Dapsone should be withdrawn. Recovery on withdrawal is usually substantially complete. The mechanism of recovery is reported by axonal regeneration. Some recovered patients have tolerated retreatment at reduced dosage. In leprosy this complication may be difficult to distinguish from a leprosy reactional state.

Body As A Whole: In addition to the warnings and adverse effects reported above, additional adverse reactions include: nausea, vomiting, abdominal pains, pancreatitis, vertigo, blurred vision, tinnitus, insomnia, fever, headache, psychosis, phototoxicity, pulmonary eosinophilia, tachycardia, albuminuria, the nephrotic syndrome, hypoalbuminemia without proteinuria, renal papillary necrosis, male infertility, drug-induced Lupus erythematosus and an infectious mononucleosis-like syndrome. In general, with the exception of the complications of severe anoxia from overdosage (retinal and optic nerve damage, etc.) these adverse reactions have regressed off drug.





REPORTS OF SUSPECTED DAPSONE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Dapsone. The information is not vetted and should not be considered as verified clinical evidence.

Possible Dapsone side effects / adverse reactions in 49 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-11

Patient: 49 year old female weighing 55.0 kg (121.0 pounds)

Reactions: Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Suspect drug(s):
Epinastine Hydrochloride
    Administration route: Oral
    Indication: Pustular Psoriasis
    Start date: 2010-05-21
    End date: 2010-07-02

Pepcid RPD
    Administration route: Oral
    Indication: Prophylaxis Against Gastrointestinal Ulcer
    Start date: 2010-04-15
    End date: 2010-07-02

Dapsone
    Administration route: Oral
    Indication: Acute Febrile Neutrophilic Dermatosis
    Start date: 2010-04-26
    End date: 2010-07-02

Other drugs received by patient: Biotin; Loxonin; Biofermin



Possible Dapsone side effects / adverse reactions in 48 year old female

Reported by a physician from United States on 2011-10-19

Patient: 48 year old female

Reactions: Squamous Cell Carcinoma of Skin

Suspect drug(s):
Dapsone
    Indication: Behcet's Syndrome

Mycophenolate Mofetil (Cellcept)
    Indication: Behcet's Syndrome

Leukeran
    Indication: Behcet's Syndrome

Imuran
    Indication: Behcet's Syndrome

Enbrel
    Indication: Behcet's Syndrome

Prednisone
    Indication: Behcet's Syndrome

Methotrexate
    Indication: Behcet's Syndrome

Plaquenil
    Indication: Behcet's Syndrome

Cyclosporine
    Indication: Behcet's Syndrome

Remicade
    Indication: Behcet's Syndrome

Rituxan
    Indication: Behcet's Syndrome

Colchicine
    Indication: Behcet's Syndrome

Cytoxan
    Indication: Behcet's Syndrome

Arava
    Indication: Behcet's Syndrome

Other drugs received by patient: Pregabalin; Acyclovir; Folic Acid; Furosemide; Terbutaline Sulfate; Erythromycin; Esomeprazole Sodium; Pentoxifylline; Theophylline; Fentanyl-100; Fluticasone Propionate/salmeterol; Sertraline Hydrochloride



Possible Dapsone side effects / adverse reactions in 12 year old female

Reported by a pharmacist from United States on 2011-10-26

Patient: 12 year old female

Reactions: Oxygen Saturation Decreased

Suspect drug(s):
Dapsone



See index of all Dapsone side effect reports >>

Drug label data at the top of this Page last updated: 2010-11-18

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