ADVERSE REACTIONS
In hospitalized patients, the most frequently reported were
dizziness, sedation, nausea, and vomiting. Other adverse reactions include
constipation, abdominal pain, skin rashes, lightheadedness, headache, weakness,
euphoria, dysphoria, hallucinations, and minor visual disturbances.
The most frequently reported postmarketing adverse events have included
completed suicide, accidental and intentional overdose, drug dependence, cardiac
arrest, coma, drug ineffective, drug toxicity, nausea, respiratory arrest,
cardio-respiratory arrest, death, vomiting, dizziness, convulsion, confusional
state, and diarrhea.
Additional adverse experiences reported through postmarketing surveillance
include:
Cardiac disorders: arrhythmia, bradycardia,
cardiac/respiratory arrest, congestive arrest, congestive heart failure (CHF),
tachycardia, myocardial infarction (MI)
Eye disorder: eye swelling, vision blurred
General disorder and administration site conditions:
drug ineffective, drug interaction, drug tolerance, influenza type illness, drug
withdrawal syndrome
Gastrointestinal disorder: gastrointestinal bleed,
acute pancreatitis
Hepatobiliary disorder: hepatic steatosis,
hepatomegaly, hepatocellular injury
Immune system disorder: hypersensitivity
Injury poisoning and procedural complications: drug
toxicity, hip fracture, multiple drug overdose, narcotic overdose
Investigations: blood pressure decreased, heart rate
elevated/abnormal
Metabolism and nutrition disorder: metabolic acidosis
Nervous system disorder: ataxia, coma, dizziness,
somnolence, syncope
Psychiatric: abnormal behavior, confusional state,
hallucinations, mental status change
Respiratory, thoracic, and mediastinal disorders:
respiratory depression, dyspnoea
Skin and subcutaneous tissue disorder: rash, itch
Liver dysfunction has been reported in association with Darvon-N.
Propoxyphene therapy has been associated with abnormal liver function tests and,
more rarely, with instances of reversible jaundice (including cholestatic
jaundice).
Subacute painful myopathy has been reported following chronic propoxyphene
overdosage.
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REPORTS OF SUSPECTED DARVON-N SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Darvon-N. The information is not vetted and should not be considered as verified clinical evidence.
Possible Darvon-N side effects / adverse reactions in 84 year old female
Reported by a consumer/non-health professional from Canada on 2012-01-27
Patient: 84 year old female
Reactions: Wrong Drug Administered, Product Label Confusion
Adverse event resulted in: death
Suspect drug(s):
MS Contin
Dosage: 60 mg, unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Darvon-N
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Darvon-N side effects / adverse reactions in 84 year old female
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-01-31
Patient: 84 year old female
Reactions: Wrong Drug Administered, Product Label Confusion
Adverse event resulted in: death
Suspect drug(s):
MS Contin
Dosage: 60 mg, unk
Administration route: Oral
Darvon-N
Administration route: Oral
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