Deltasone (Prednisone) - Summary

DELTASONE SUMMARY

Deltasone tablets contain prednisone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.

Prednisone tablets are indicated in the following conditions:

1. Endocrine Disorders:

Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance).

Congenital adrenal hyperplasia.

Hypercalcemia associated with cancer.

Nonsuppurative thyroiditis.

2. Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

Psoriatic arthritis.

Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy).

Ankylosing spondylitis.

Acute and subacute bursitis.

Acute nonspecific tenosynovitis.

Acute gouty arthritis.

Post-traumatic osteoarthritis.

Synovitis of osteoarthritis.

Epicondylitis.

3. Collagen Diseases: During an exacerbation or as maintenance therapy in selected cases of:

Systemic lupus erythematosus.

Systemic dermatomyositis (polymyositis).

Acute rheumatic carditis.

4. Dermatological Diseases:

Pemphigus.

Bullous dermatitis herpetiformis.

Severe erythema muliforme (Stevens-Johnson syndrome).

Exfoliative dermatitis.

Mycosis fungoides.

Severe psoriasis.

Severe seborrheic dermatitis.

5. Allergic States: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:

Seasonal or perennial allergic rhinitis.

Bronchial asthma.

Contact dermatitis.

Atopic dermatitis.

Serum sickness.

Drug hypersensitivity reactions.

6. Ophthalmic Diseases: Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as:

Allergic corneal marginal ulcers.

Herpes zoster ophthalmicus.

Anterior segment inflammation.

Diffuse posterior uveitis and choroiditis.

Sympathetic ophthalmia.

Allergic conjunctivitis.

Keratitis.

Chorioretinitis.

Optic neuritis.

Iritis and iridocyclitis.

7. Respiratory Diseases:

Symptomatic sarcoidosis.

Loeffler's syndrome not manageable by other means.

Berylliosis.

Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy.

Aspiration pneumonitis.

8. Hematologic Disorders:

Idiopathic thrombocytopenic purpura in adults.

Secondary thrombocytopenia in adults.

Acquired (autoimmune) hemolytic anemia.

Erythroblastopenia (RBC anemia).

Congenital (erythroid) hypoplastic anemia.

9. Neoplastic Diseases: For palliative management of:

Leukemias and lymphomas in adults.

Acute leukemia of childhood.

10. Edematous States:

To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.

11. Gastrointestinal Diseases: To tide the patient over a critical period of the disease in:

Ulcerative colitis.

Regional enteritis.

12. Nervous System:

Acute exacerbations of multiple sclerosis.

13. Miscellaneous:

Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy.

Trichinosis with neurologic or myocardial involvement.

NEWS HIGHLIGHTS

Published Studies Related to Deltasone (Prednisone)

Abiraterone acetate plus prednisone versus prednisone alone in chemotherapy-naive men with metastatic castration-resistant prostate cancer: patient-reported outcome results of a randomised phase 3 trial. [2013]
pain and functional status in a preplanned interim analysis of a phase 3 trial... INTERPRETATION: Abiraterone plus prednisone delays patient-reported pain

Are changes in bone mineral density different between groups of early rheumatoid arthritis patients treated according to a tight control strategy with or without prednisone if osteoporosis prophylaxis is applied? [2013]
prednisone in early RA patients who received preventive therapy for osteoporosis... CONCLUSION: Addition of 10 mg prednisone daily to a methotrexate-based tight

Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised trial. [2012]
docetaxel chemotherapy... INTERPRETATION: In patients with metastatic castration-resistant prostate cancer

Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. [2012]
AT-101 (A) or placebo in chemonaive mCRPC... CONCLUSIONS: AT-101 was tolerable but did not extend OS when combined with DP in

Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. [2011.11.29]
BACKGROUND: AT-101 (A), a small molecule oral inhibitor of the Bcl-2 family, has activity alone and in combination with docetaxel (Taxotere) and prednisone (DP) in metastatic castration-resistant prostate cancer (mCRPC). A randomized, double-blind, placebo-controlled phase II trial compared DP combined with either AT-101 (A) or placebo in chemonaive mCRPC... CONCLUSIONS: AT-101 was tolerable but did not extend OS when combined with DP in mCRPC; a potential benefit was observed in high-risk patients.

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Clinical Trials Related to Deltasone (Prednisone)

The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach [Recruiting]
This is a randomized controlled trial in patients with a diagnosis of granulomatosis with polyangiitis (GPA; Wegener's)that are in remission to evaluate the effects of using low-dose glucocorticoids ( 5 mg/day of prednisone) as compared to stopping glucocorticoid treatment entirely (0 mg/day of prednisone)on rates of disease relapse/disease flares. This study is a novel approach to conducting a randomized clinical trial in the community setting. This study is being conducted in parallel with a similar study at established vasculitis institutions. This study will have a patient centric approach to research in that subjects will be recruited online and through social media and vasculitis support networks. Participants will be consented online and will receive care through their regular treating physician so no travel or additional doctor visits are required. Study participants will consent to the study and complete online questionnaires about their prednisone dose and about how they are feeling.

Prednisone Withdrawal Versus Prednisone Maintenance After Kidney Transplant [Terminated]
The purpose of the study was to determine if rapid discontinuation of corticosteroids (also known as prednisone withdrawal) and maintenance immunosuppression with Prograf (tacrolimus) and CellCept (mycophenolate mofetil) while using Thymoglobulin (Rabbit antithymocyte globulin) will give similar safety and efficacy results compared to continuation of corticosteroids (also known as prednisone maintenance) and standard maintenance immunosuppression with Prograf (tacrolimus), CellCept (mycophenolate mofetil) while using Thymoglobulin (Rabbit antithymocyte globulin).

Dose-comparison Study of Prednisone in Heart Failure [Completed]
The purpose of this study is to examine the efficacy of three doses of prednisone, a glucocorticoid, in treatment of patients with symptomatic heart failure.

Use of a Single Dose of Oral Prednisone in the Treatment of Cellulitis [Recruiting]
Cellulitis is the medical term for an infection of the skin, with symptoms including redness, swelling, warmth, and pain. This group of symptoms is called inflammation, and is caused by the body's immune system responding to the infection. Standard care for cellulitis is using antibiotics to destroy the infection, but the inflammation can persist and cause a great deal of pain. The hypothesis of this study is that adding a single dose of an oral steroid (prednisone), which tempers the immune response, will reduce inflammation, reduce pain, and speed recovery. This hypothesis will be examined by recruiting a group of patients with cellulitis, and randomizing them to two sub-groups: one group will receive a dose of prednisone, while the other group will receive a placebo. Neither group will know what they received unless there is a problem. These subjects will be followed up at the 48 hour mark and the 7 day mark, and will have their results compared.

The Assessment of Prednisone In Remission Trial - Centers of Excellence Approach [Recruiting]
This study is a multi-center randomized controlled trial to evaluate the effects of using low-dose prednisone as compared to stopping prednisone treatment entirely. Participants will be randomized 1: 1 to taper their prednisone dose down to 5 mg/day or to 0 mg/day for the duration of the study (approximately six months) or until a study endpoint.

more trials >>

PATIENT REVIEWS / RATINGS / COMMENTS

Deltasone review by 16 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		severe poison ivy all over face
Dosage & duration:		20mg taken 3 daily for the period of 5 days
Other conditions:		strep throat
Other drugs taken:		amoxicillan
		Reported Results
Benefits:		it cleared away my face from poison ivy basically over night.
Side effects:		there were no side effects.
Comments:		i went to the doctors on Thursday. my throat hurt real bad and i pretty much knew i had strep throat because i have had it before. so they told me to take amoxacillin 500mg every 8 hours. it worked real good next day throat felt ten times better but still have to take it until the bottle runs out so it doesnt come back. so come sunday night i wake up in the middle of the night itching my forehead. i woke up looked like a rash. went back to bed and woke up in the morning and still there. it scared me a little bit thought it was an allergic reaction so i went to the doc and she told me she didnt know 100% if it was an allergic reaction to amoxacillin or if it was strep throat. so switched my anibiotics and got hydroxyzine for itch relief but nothing for the rash itself! so next day kept getting worse and wosre finally that night i went to the er and a different doctor told me it wasnt medicine related at all and thought it was poison ivy which i get a lot! it didnt look like any poison ivy ive ever had though. so they gave me a prednisone shot in the butt and pills for the next five days. the next morning it was pretty much clear whatever it was i dont care because it gone and doesnt bother me anymore. prednisone worked great for me.

Deltasone review by 53 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		Crohn's Disease
Dosage & duration:		50 mg to start taken daily for the period of 4 -6 weeks
Other conditions:		none
Other drugs taken:		imodium
		Reported Results
Benefits:		Remission of Crohn's Disease. Remission included normal bowel movenments from about 15/day to 1 or 2 per day. Cramps associated with diarrhea have disappeared. Increased energy, feeling active and generally feeling better. Endoscopy was done at one point after the treatment and there was indication of only very mild disease so basically remission was achieved according to my gastroenterologist.
Side effects:		Edema, weight gain, round face occurring about 3 weeks into the treatment. Insomnia, headache and hperactivity occurred at 50 mg daily, and subsided when dose decreased to 40 mg daily. I was first diagnosed with Crohn's in 1980 and at that time not too much was known about effective treatments and so on. My gastroenterologist at the time prescribed 5mg of prednisone daily for an indefinite period of time. This did not help at all, in fact I became sicker and sicker, lost a lot of weight and had frequent diarrhea and severe cramps all day. I became osteopenic and had a bowel perforation 2 years later. The perforation was believed to be due to the long term prenisone I was taking. I had a bowel resection done. A new Gastroenterologist started me on a new treatment schedule.
Comments:		The new treatment schedule started with 50 qam for 1 week. Decrease to 40 mg for a week, and then slowly keep decreasing by 5 mg daily, for a week at a time, until finished. Usually takes about a month. I only needed to take prednisone about once a year when flare-ups occurred. Remission periods between flareups became further and further apart as I became older, often years, so I am no longer osteopenic as a result.