Depo-Estradiol (Estradiol Cypionate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

See BOXED WARNINGS, WARNINGS and PRECAUTIONS.

The following additional adverse reactions have been reported with estrogens and/or progestin therapy.

• 1. Genitourinary system
  Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting; dysmenorrhea; increase in size of uterine leiomyomata; vaginitis including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer.
• 2. Breasts
  Tenderness, enlargement pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer.
• 3. Cardiovascular
  Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure.
• 4. Gastrointestinal
  Nausea, vomiting; abdominal cramps, bloating; cholestatic jaundice; increased incidence of gallbladder disease; pancreatitis, enlargement of hepatic hemangiomas.
• 5. Skin
  Chloasma or melasma that may persist when drug is discontinued. Erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism; pruritus, rash.
• 6. Eyes
  Retinal vascular thrombosis; steepening of corneal curvature; intolerance to contact lenses.
• 7. Central nervous system
  Headache, migraine, dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia.
• 8. Miscellaneous
  Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; changes in libido; arthralgias; leg cramps; anaphylactoid/anaphylactic reactions including urticaria and angioedema; hypocalcemia; exacerbation of asthma; increased triglycerides.

REPORTS OF SUSPECTED DEPO-ESTRADIOL SIDE EFFECTS / ADVERSE REACTIONS

Possible Depo-Estradiol side effects / adverse reactions in 53 year old female

Reported by a pharmacist from United States on 2012-08-24

Patient: 53 year old female

Reactions: Drug Ineffective

Suspect drug(s):
Depo-Estradiol

Other drugs received by patient: Lidoderm; Cymbalta; Synthroid