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Depo-Estradiol (Estradiol Cypionate) - Side Effects and Adverse Reactions




The following additional adverse reactions have been reported with estrogens and/or progestin therapy.

  • 1. Genitourinary system
    Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting; dysmenorrhea; increase in size of uterine leiomyomata; vaginitis including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer.
  • 2. Breasts
    Tenderness, enlargement pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer.
  • 3. Cardiovascular
    Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure.
  • 4. Gastrointestinal
    Nausea, vomiting; abdominal cramps, bloating; cholestatic jaundice; increased incidence of gallbladder disease; pancreatitis, enlargement of hepatic hemangiomas.
  • 5. Skin
    Chloasma or melasma that may persist when drug is discontinued. Erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism; pruritus, rash.
  • 6. Eyes
    Retinal vascular thrombosis; steepening of corneal curvature; intolerance to contact lenses.
  • 7. Central nervous system
    Headache, migraine, dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia.
  • 8. Miscellaneous
    Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; changes in libido; arthralgias; leg cramps; anaphylactoid/anaphylactic reactions including urticaria and angioedema; hypocalcemia; exacerbation of asthma; increased triglycerides.


Below is a sample of reports where side effects / adverse reactions may be related to Depo-Estradiol. The information is not vetted and should not be considered as verified clinical evidence.

Possible Depo-Estradiol side effects / adverse reactions in 53 year old female

Reported by a pharmacist from United States on 2012-08-24

Patient: 53 year old female

Reactions: Drug Ineffective

Suspect drug(s):

Other drugs received by patient: Lidoderm; Cymbalta; Synthroid

See index of all Depo-Estradiol side effect reports >>

Drug label data at the top of this Page last updated: 2013-08-20

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