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Detrol LA (Tolterodine Tartrate) - Indications and Dosage



DETROL LA Capsules is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency [see CLINICAL STUDIES ].


Dosing Information

The recommended dose of DETROL LA Capsules is 4 mg once daily with water and swallowed whole. The dose may be lowered to 2 mg daily based on individual response and tolerability; however, limited efficacy data are available for DETROL LA 2 mg [see CLINICAL STUDIES ].

Dosage Adjustment in Specific Populations

For patients with mild to moderate hepatic impairment (Child-Pugh Class A or B) or severe renal impairment (CCr 10–30 mL/min), the recommended dose of DETROL LA is 2 mg once daily. DETROL LA is not recommended for use in patients with severe hepatic impairment (Child-Pugh Class C). Patients with CCr<10 mL/min have not been studied and use of DETROL LA in this population is not recommended [see WARNINGS AND PRECAUTIONS and USE IN SPECIFIC POPULATIONS (8.6, 8.7) ].

Dosage Adjustment in Presence of Concomitant Drugs

For patients who are taking drugs that are potent inhibitors of CYP3A4 [e.g., ketoconazole, clarithromycin, ritonavir], the recommended dose of DETROL LA is 2 mg once daily [see DRUG INTERACTIONS ].


The 2 mg capsules are blue-green with symbol and 2 printed in white ink.

The 4 mg capsules are blue with symbol and 4 printed in white ink.


DETROL LA Capsules are supplied as follows:

Bottles of 30 Bottles of 500
2 mg Capsules NDC 0009-5190-01 2 mg Capsules NDC 0009-5190-03
4 mg Capsules NDC 0009-5191-01 4 mg Capsules NDC 0009-5191-03
Bottles of 90 Unit Dose Blisters
2 mg Capsules NDC 0009-5190-02 2 mg Capsules NDC 0009-5190-04
4 mg Capsules NDC 0009-5191-02 4 mg Capsules NDC 0009-5191-04

Store at 20°–25°C (68°–77°F); excursions permitted to 15–30°C (59–86°F) [see USP Controlled Room Temperature]. Protect from light.

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