DIFFERIN SUMMARY
DIFFERIN® (adapalene) Cream, 0.1%, contains adapalene 0.1% in an aqueous cream emulsion consisting of carbomer 934P, cyclomethicone, edetate disodium, glycerin, methyl glucose sesquistearate, methylparaben, PEG-20 methyl glucose sesquistearate, phenoxyethanol, propylparaben, purified water, squalane, and trolamine.
DIFFERIN® Cream is indicated for the topical treatment of acne vulgaris.
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NEWS HIGHLIGHTSMedia Articles Related to Differin (Adapalene)
Acne Treatment Differin Gel Approved for OTC Use
Source: MedicineNet adapalene Specialty [2016.07.12]
Title: Acne Treatment Differin Gel Approved for OTC Use
Category: Health News
Created: 7/11/2016 12:00:00 AM
Last Editorial Review: 7/12/2016 12:00:00 AM
Health Tip: Four Common Types Of Acne
Source: MedicineNet Acne Specialty [2017.09.20]
Title: Health Tip: Four Common Types Of Acne
Category: Health News
Created: 9/20/2017 12:00:00 AM
Last Editorial Review: 9/20/2017 12:00:00 AM
Acne (Pimples) Quiz: Test Your Medical IQ
Source: MedicineNet Acne Specialty [2017.09.19]
Title: Acne (Pimples) Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 2/28/2011 4:15:00 PM
Last Editorial Review: 9/19/2017 5:39:39 PM
Skin Quiz: Acne, Dry Skin, Dandruff & More
Source: MedicineNet Acne Specialty [2017.09.19]
Title: Skin Quiz: Acne, Dry Skin, Dandruff & More
Category: MedicineNet Quiz
Created: 10/7/2010 12:00:00 AM
Last Editorial Review: 9/19/2017 5:01:04 PM
Health Tip: Can't Clear Your Acne?
Source: MedicineNet Acne Specialty [2017.08.02]
Title: Health Tip: Can't Clear Your Acne?
Category: Health News
Created: 8/2/2017 12:00:00 AM
Last Editorial Review: 8/2/2017 12:00:00 AM
Published Studies Related to Differin (Adapalene)
The efficacy, safety, and tolerability of adapalene versus benzoyl peroxide in
the treatment of mild acne vulgaris: a randomized trial. [2013]
Topical treatments, such as adapalene and benzoyl peroxide (BPO), are popular in
mild-to-moderate acne vulgaris... Both topical adapalene 0.1% and BPO 2.5% gels seem
safe and effective in mild acne vulgaris, with a marginal tendency toward the
former.
Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study. [2011.08]
BACKGROUND: Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris. OBJECTIVES: To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0.1%-BPO 2.5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris... CONCLUSION: These results demonstrate the clinical benefit of combining A/BPO with lymecycline in the treatment of moderate to severe acne vulgaris. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists 2011.
A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial. [2011.06]
BACKGROUND: Acne vulgaris is a chronic and frequently recurring disease. A fixed-dose adapalene-benzoyl peroxide (adapalene-BPO) gel is an efficacious and safe acne treatment. OBJECTIVES: To assess the long-term effect of adapalene-BPO on relapse prevention among patients with severe acne after successful initial treatments... CONCLUSIONS: Adapalene-BPO not only prevents the occurrence of relapse among patients with severe acne, but also continues to reduce disease symptoms during 6 months. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists.
The efficacy of adapalene-benzoyl peroxide combination increases with number of
acne lesions. [2011]
vehicle varies with baseline lesion counts... CONCLUSION: The relative benefit of adapalene-BPO increases with higher lesion
Irritation potential of tretinoin gel microsphere pump versus adapalene plus benzoyl peroxide gel. [2010.08]
This single-center, investigator-blinded, randomized, split-face, phase 4 study compared the irritation potential of tretinoin gel microsphere (TGM) 0.04% in a pump dispenser with adapalene 0.1% plus benzoyl peroxide 2.5% gel (ADA-BPO 0.1%/2.5%) in a panel of 170 subjects... While both agents were well tolerated by most patients, TGM 0.04% pump demonstrated significantly better tolerance than ADA-BPO 0.1%/2.5% gel in both neurosensory parameters and signs of contact irritation.
Clinical Trials Related to Differin (Adapalene)
Evaluation of Quality of Life, Efficacy, and Tolerance of Duac� Gel Compared to Differin� Gel in the Treatment of Acne [Completed]
The objectives of this clinical trial are to compare the quality of life of the subjects,
the efficacy and the tolerance of Duac® Gel (gel formulation with a combination of
clindamycin phosphate [equivalent to 1% clindamycin] and 5% benzoyl peroxide), applied once
daily, against Differin® Gel (gel with 0. 1% adapalene), used once daily, in the treatment of
mild to moderate acne vulgaris.
Study Comparing Adapalene Gel 0.3% to Differin� and Both to a Placebo Control in Treatment of Acne Vulgaris [Completed]
Tolerability Comparison Between Differin� Cream 0.1% Versus Differin� Lotion 0.1% in Subjects With Healthy Skin [Completed]
The purpose of this study is to compare the tolerability of Differin® (adapalene) Cream,
0. 1% to Differin® Lotion, 0. 1% in subjects with healthy skin treated once a day for three
(3) weeks.
Tolerability Comparison of Differin� Cream 0.1% Versus Differin® Lotion 0.1% in Subjects With Healthy Skin [Completed]
The purpose of this study is to compare the tolerability of Differin® (adapalene) Cream,
0. 1% to Differin® Lotion, 0. 1% in subjects with healthy skin treated once a day for three
(3) weeks.
A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging [Recruiting]
The purpose of this study is to:
1. Evaluate the efficacy of Adapalene gel 0. 3% compared to Tretinoin Emollient cream
0. 05%, reducing signs of cutaneous photoageing, measured trough photonumeric scale
evaluation, investigator evaluation of global response to treatment and subject's
evaluation of improvement.
2. Evaluate the safety and tolerability of Adapalene Gel 0. 3%, compared to Tretinoin
Emollient cream 0. 05% during 24 weeks of treatment.
The study has the clinical hypothesis that Adapalene Gel 0. 3% is as effective as Tretinoin
Emollient cream 0. 05% in the treatment of cutaneous photoaging.
Reports of Suspected Differin (Adapalene) Side Effects
Erythema (4),
Blister (4),
Skin Irritation (4),
Pruritus (3),
Burning Sensation (3),
Burns Second Degree (3),
Burns Third Degree (2),
Rash (2),
Facial Pain (2),
Eye Swelling (2), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 38 ratings/reviews, Differin has an overall score of 6.89. The effectiveness score is 6.84 and the side effect score is 7.95. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Differin review by 37 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Acne |
| Dosage & duration: | | gel .3% (dosage frequency: 2 times a day) for the period of 4 weeks |
| Other conditions: | | enlarged pores |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The pimples become dry. At first there was formation of new pimples, but then pimples started gradually go away; overall the skin started looking healthier and cleaner. |
| Side effects: | | some bearable feeling of heat/burning |
| Comments: | | applied the gel in the morning and at night on nose, cheeks, forehead, and chin. |
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| | Differin review by 22 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Acne problem |
| Dosage & duration: | | Apply it all over the face (dosage frequency: every night) for the period of 2 months |
| Other conditions: | | Pits and blemishes over the skin. |
| Other drugs taken: | | Azee | | |
Reported Results |
| Benefits: | | Texture of the skin has improved a lot by regularly going for peel sessions and by using the prescribed drugs which has to be used through out the treatment period. |
| Side effects: | | The negative side is controlling acne during the treatment period is little tough as new skin appears , so one has to keep his face clean by having lots of water and constantly washing the face with the face wash solution prescribed. |
| Comments: | | The treatment is to improve the skin texture,complexion by constantly going for peels and derma-rollers once in 15days.The above mentioned medicine is prescribed to be used through out the treatment period. |
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| | Differin review by 24 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | daily (dosage frequency: daily) for the period of three months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | There were little to no benefits to using differin to treat acne. while it may have helped exfoliation, it did little to treat current and to prevent future acne. instead of differin, using a separate skin exfoliation product in addition to an over the counter acne treatment might have been more beneficial. My acne worsened using Differin -- some say it is because the impurities are being purged from beneath the outer layers of the skin. I don't know if I completely buy this theory though I would have believed it if it showed some improvement after three months. Unfortunately, it did not. |
| Side effects: | | There were no side effects to the treatment except that it worsened my breakouts. However, it did nothing to take down the flares even after three months of treatment. Soon after I stopped using it, my skin improved. So now, I choose to use an exfoliation product and a separate over the counter acne treatment product. |
| Comments: | | differin did not help prevent acne or get rid of current acne. it worsened the condition though it was explained that as it helped the skin exfoliate, the impurities beneath the outer skin surfaced. however, there were no improvements after three months of application. |
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Page last updated: 2017-09-20
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