ADVERSE REACTIONS
Adverse reactions to isosorbide dinitrate are generally dose
related, and almost all of these reactions are the result of isosorbide
dinitrate's activity as a vasodilator. Headache, which may be severe, is
the most commonly reported side effect. Headache may be recurrent with
each daily dose, especially at higher doses. Transient episodes of
lightheadedness, occasionally related to blood pressure changes, may
also occur. Hypotension occurs infrequently, but in some patients it may
be severe enough to warrant discontinuation of therapy. Syncope,
crescendo angina, and rebound hypertension have been reported but are
uncommon.
Extremely rarely, ordinary doses of organic nitrates have caused
methemoglobinemia in normal-seeming patients. Methemoglobinemia is so
infrequent at these doses that further discussion of its diagnosis and
treatment is deferred (see OVERDOSAGE).
Data are not available to allow estimation of the frequency of
adverse reactions during treatment with dilatrate®-SR sustained release
capsules.
|