NEWS HIGHLIGHTS
Published Studies Related to Dimenhydrinate
Dimenhydrinate in children with infectious gastroenteritis: a prospective, RCT. [2009] efficacy and safety of dimenhydrinate in children with acute gastroenteritis... CONCLUSIONS: Dimenhydrinate reduces the frequency of vomiting in children with
Treatment of vertebrobasilar insufficiency--associated vertigo with a fixed combination of cinnarizine and dimenhydrinate. [2008] Thirty-seven patients suffering from vertigo associated with vertebrobasilar insufficiency participated in our prospective, single-center, double-blind, comparative study. Patients were randomly allocated to treatment with placebo; betahistine (12 mg betahistine dimesylate, one tablet three times daily); or the fixed combination of 20 mg cinnarizine and 40 mg dimenhydrinate (one tablet three times daily) for 4 weeks...
A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders : a randomized, reference-controlled clinical study. [2008] BACKGROUND AND OBJECTIVE: Vestibular dysfunction commonly leads to - often severe - vertigo symptoms. The objective of this study was to compare the antivertiginous efficacy and tolerability of a fixed combination of cinnarizine/dimenhydrinate with those of betahistine in patients with acute vertigo due to vestibular disorders... CONCLUSION: The fixed combination of cinnarizine/dimenhydrinate was shown to be an effective and very well tolerated treatment option for patients with acute vertigo due to vestibular disorders. The combination proved to be significantly more efficient in reducing vertigo and associated vegetative symptoms than betahistine in such patients.
A randomized comparison of ginger and dimenhydrinate in the treatment of nausea
and vomiting in pregnancy. [2007] nausea and vomiting in pregnancy... CONCLUSION: From the presented data, ginger is as effective as dimenhydrinate in
Treatment of vertigo due to acute unilateral vestibular loss with a fixed
combination of cinnarizine and dimenhydrinate: a double-blind, randomized,
parallel-group clinical study. [2004] vertigo symptoms due to acute unilateral vestibular loss... CONCLUSIONS: The results of this study suggest a distinct benefit in using a
Clinical Trials Related to Dimenhydrinate
Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo [Completed]
- Vertigo complaint is one of the common cause of patients who applied to emergency
services.
- Patients who have applied to emergency services with vertigo complaint mostly have
nausea as an additionally symptom to this complaint and anti-emetic agents can be used
in their treatments very often.
- The investigators purpose is to investigate the advantages of Dimenhydrinate and
metoclopramide to each other in the treatment of vertigo and the vertigo accompanied by
nausea
Prophylactic Dimenhydrinate for Intraoperative Nausea and Vomiting [Completed]
The purpose of this study will be to determine whether an intravenous dose of dimenhydrinate
(also known as Gravol), given before the induction of spinal anesthesia, will decrease the
incidence of intraoperative nausea and vomiting in patients undergoing Cesarean delivery.
This medication is commonly given during and after the surgery if required, but it is not
known whether a preventative dose will decrease the overall incidence of these side effects.
Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo [Completed]
This study aims to investigate efficacy of two different intravenous drugs (dimenhydrinate
and piracetam) in the symptomatic management of peripheral vertigo.
The patients will be randomized in two groups according to symptomatic treatment modalities:
Dimenhydrinate (100 mg) and piracetam (2 g) will be given in 100 cc normal saline in 30
minutes. Each patient will be asked if her/his vertigo symptoms resolved or not, according
to a numeric rating scale (0=no vertigo, 10=worst possible vertigo). The patient will be
rate the intensity of symptoms in the following times:
- Numeric rating scale (1 to 10): Admission
- Numeric rating scale (1 to 10): After the study drug (No ambulation)*
- Numeric rating scale (1 to 10): After the study drug (Ambulation)*
- Ambulation refers to head movements or walking in the room, if applicable.
A Trial Comparing the Effect of Oral Dimenhydrinate Versus Placebo in Children With Gastroenteritis [Completed]
Dimenhydrinate, an over-the-counter, widely used drug in Canada, is an
ethanolamine-derivative anti-histamine. It limits the stimulation of the vomiting center by
the vestibular system, which is rich in histamine receptors. Multiple studies have shown
its effectiveness in treatment of post-operative nausea and vomiting in children.
It is also used for treatment of vertigo in children. Furthermore, it has the potential to
be much more cost-effective than ondansetron, with an average cost of $0. 90 US per dose .
Its principal side effects are drowsiness, dizziness and anticholinergic symptoms.
Restlessness and insomnia have also been described in children. To date, there has been no
published data on the efficacy of dimenhydrinate in controlling emesis in children with
acute gastroenteritis.
RESEARCH QUESTION
Do children treated with oral dimenhydrinate during acute gastro-enteritis experience less
vomiting episodes than children treated with placebo?
Prevention of Postoperative Nausea and Vomiting [Completed]
We designed this randomized, double- blind, single-center study to compare the efficacy of
the combination of dexamethasone with ondansetron and dexamethasone with dimenhydrinate
undergoing plastic surgery.
Reports of Suspected Dimenhydrinate Side Effects
Toxic Epidermal Necrolysis (3),
Agitation (1),
Body Temperature Increased (1),
Tachycardia (1),
Anaphylactic Shock (1),
Drug Interaction (1),
Drug Withdrawal Syndrome Neonatal (1),
Hyperhidrosis (1),
Gastroschisis (1),
Malaise (1), more >>
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