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Dimenhydrinate (Dimenhydrinate) - Summary



Dimenhydrinate, an anti-nauseant/antiemetic, is the 8-chlorotheophylline salt of diphenhydramine.   It contains not less than 53% and not more than 55.5% of diphenhydramine, and not less than 44% and not more than 47% of 8-chlorotheophylline, calculated on the dried basis.

Dimenhydrinate Injection, USP is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.

See all Dimenhydrinate indications & dosage >>


Published Studies Related to Dimenhydrinate

Dimenhydrinate in children with infectious gastroenteritis: a prospective, RCT. [2009]
efficacy and safety of dimenhydrinate in children with acute gastroenteritis... CONCLUSIONS: Dimenhydrinate reduces the frequency of vomiting in children with

Treatment of vertebrobasilar insufficiency--associated vertigo with a fixed combination of cinnarizine and dimenhydrinate. [2008]
Thirty-seven patients suffering from vertigo associated with vertebrobasilar insufficiency participated in our prospective, single-center, double-blind, comparative study. Patients were randomly allocated to treatment with placebo; betahistine (12 mg betahistine dimesylate, one tablet three times daily); or the fixed combination of 20 mg cinnarizine and 40 mg dimenhydrinate (one tablet three times daily) for 4 weeks...

A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders : a randomized, reference-controlled clinical study. [2008]
BACKGROUND AND OBJECTIVE: Vestibular dysfunction commonly leads to - often severe - vertigo symptoms. The objective of this study was to compare the antivertiginous efficacy and tolerability of a fixed combination of cinnarizine/dimenhydrinate with those of betahistine in patients with acute vertigo due to vestibular disorders... CONCLUSION: The fixed combination of cinnarizine/dimenhydrinate was shown to be an effective and very well tolerated treatment option for patients with acute vertigo due to vestibular disorders. The combination proved to be significantly more efficient in reducing vertigo and associated vegetative symptoms than betahistine in such patients.

A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. [2007]
nausea and vomiting in pregnancy... CONCLUSION: From the presented data, ginger is as effective as dimenhydrinate in

Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: a double-blind, randomized, parallel-group clinical study. [2004]
vertigo symptoms due to acute unilateral vestibular loss... CONCLUSIONS: The results of this study suggest a distinct benefit in using a

more studies >>

Clinical Trials Related to Dimenhydrinate

Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo [Completed]

- Vertigo complaint is one of the common cause of patients who applied to emergency


- Patients who have applied to emergency services with vertigo complaint mostly have

nausea as an additionally symptom to this complaint and anti-emetic agents can be used in their treatments very often.

- The investigators purpose is to investigate the advantages of Dimenhydrinate and

metoclopramide to each other in the treatment of vertigo and the vertigo accompanied by nausea

Prophylactic Dimenhydrinate for Intraoperative Nausea and Vomiting [Completed]
The purpose of this study will be to determine whether an intravenous dose of dimenhydrinate (also known as Gravol), given before the induction of spinal anesthesia, will decrease the incidence of intraoperative nausea and vomiting in patients undergoing Cesarean delivery. This medication is commonly given during and after the surgery if required, but it is not known whether a preventative dose will decrease the overall incidence of these side effects.

Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo [Completed]
This study aims to investigate efficacy of two different intravenous drugs (dimenhydrinate and piracetam) in the symptomatic management of peripheral vertigo. The patients will be randomized in two groups according to symptomatic treatment modalities: Dimenhydrinate (100 mg) and piracetam (2 g) will be given in 100 cc normal saline in 30 minutes. Each patient will be asked if her/his vertigo symptoms resolved or not, according to a numeric rating scale (0=no vertigo, 10=worst possible vertigo). The patient will be rate the intensity of symptoms in the following times:

- Numeric rating scale (1 to 10): Admission

- Numeric rating scale (1 to 10): After the study drug (No ambulation)*

- Numeric rating scale (1 to 10): After the study drug (Ambulation)*

- Ambulation refers to head movements or walking in the room, if applicable.

A Trial Comparing the Effect of Oral Dimenhydrinate Versus Placebo in Children With Gastroenteritis [Completed]
Dimenhydrinate, an over-the-counter, widely used drug in Canada, is an ethanolamine-derivative anti-histamine. It limits the stimulation of the vomiting center by the vestibular system, which is rich in histamine receptors. Multiple studies have shown its effectiveness in treatment of post-operative nausea and vomiting in children. It is also used for treatment of vertigo in children. Furthermore, it has the potential to be much more cost-effective than ondansetron, with an average cost of $0. 90 US per dose . Its principal side effects are drowsiness, dizziness and anticholinergic symptoms. Restlessness and insomnia have also been described in children. To date, there has been no published data on the efficacy of dimenhydrinate in controlling emesis in children with acute gastroenteritis. RESEARCH QUESTION Do children treated with oral dimenhydrinate during acute gastro-enteritis experience less vomiting episodes than children treated with placebo?

Prevention of Postoperative Nausea and Vomiting [Completed]
We designed this randomized, double- blind, single-center study to compare the efficacy of the combination of dexamethasone with ondansetron and dexamethasone with dimenhydrinate undergoing plastic surgery.

more trials >>

Reports of Suspected Dimenhydrinate Side Effects

Toxic Epidermal Necrolysis (3)Agitation (1)Body Temperature Increased (1)Tachycardia (1)Anaphylactic Shock (1)Drug Interaction (1)Drug Withdrawal Syndrome Neonatal (1)Hyperhidrosis (1)Gastroschisis (1)Malaise (1)more >>

Page last updated: 2013-02-10

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