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Dimenhydrinate (Dimenhydrinate) - Drug Interactions, Contraindications, Overdosage, etc



DIMENHYDRINATE drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.


Drowsiness is the usual clinical side effect.  Convulsions, coma, and respiratory depression may occur with massive overdosage.  No specific antidote is known.  If respiratory depression occurs, mechanically assisted respiration should be initiated and oxygen should be administered.  Convulsions should be treated with appropriate doses of diazepam.  Phenobarbital (5 to 6 mg/kg) may be given to control convulsions in pediatric patients.

The oral LD50 in mice and rats is 203 mg/kg and 1320 mg/kg, respectively.  The intraperitoneal LD50 in mice is 149 mg/kg.


Neonates and patients with a history of hypersensitivity to dimenhydrinate or its components (diphenhydramine or 8-chlorotheophylline) should not be treated with dimenhydrinate.

Note: This product contains Benzyl Alcohol.  Benzyl Alcohol has been associated with a fatal “Gasping Syndrome” in premature infants and infants of low birth weight.

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