DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Disulfiram (Disulfiram) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS:

(See, AND.) CONTRAINDICATIONS WARNINGS PRECAUTIONS

OPTIC NEURITIS, PERIPHERAL NEURITIS, POLYNEURITIS, AND PERIPHERAL NEUROPATHY MAY OCCUR FOLLOWING ADMINISTRATION OF DISULFIRAM.

Multiple cases of hepatitis, including both cholestatic and fulminant hepatitis, as well as hepatic failure resulting in transplantation or death, have been reported with administration of disulfiram.

Occasional skin eruptions are, as a rule, readily controlled by concomitant administration of an antihistaminic drug.

In a small number of patients, a transient mild drowsiness, fatigability, impotence, headache, acneform eruptions, allergic dermatitis, or a metallic or garlic-like aftertaste may be experienced during the first two weeks of therapy. These complaints usually disappear spontaneously with the continuation of therapy, or with reduced dosage.

Psychotic reactions have been noted, attributable in most cases to high dosage, combined toxicity (with metronidazole or isoniazid), or to the unmasking of underlying psychoses in patients stressed by the withdrawal of alcohol.



REPORTS OF SUSPECTED DISULFIRAM SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Disulfiram. The information is not vetted and should not be considered as verified clinical evidence.

Possible Disulfiram side effects / adverse reactions in 39 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-20

Patient: 39 year old male

Reactions: Renal Failure, Acute Hepatic Failure, Intracranial Pressure Increased, Adverse Reaction

Adverse event resulted in: death

Suspect drug(s):
Acetaminophen
    Dosage: unk, unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Disulfiram
    Dosage: unk, unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication



Possible Disulfiram side effects / adverse reactions in 40 year old female

Reported by a physician from United States on 2011-12-26

Patient: 40 year old female

Reactions: Death, Cardio-Respiratory Arrest, Completed Suicide

Adverse event resulted in: death

Suspect drug(s):
Buproprion HCL
    Dosage: unk, unknown
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Disulfiram
    Dosage: unk, unknown
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Lorazepam
    Dosage: unk, unknown
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Hydroxyzine
    Dosage: unk, unknown
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Sumatriptan
    Dosage: unk, unknown
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication



Possible Disulfiram side effects / adverse reactions in 40 year old female

Reported by a physician from United States on 2011-12-29

Patient: 40 year old female

Reactions: Completed Suicide, Respiratory Arrest, Toxicity TO Various Agents, Intentional Drug Misuse, Cardiac Arrest

Adverse event resulted in: death

Suspect drug(s):
Lorazepam

Sumatriptan Succinate

Bupropion HCL

Disulfiram

Hydroxyzine



See index of all Disulfiram side effect reports >>

Drug label data at the top of this Page last updated: 2013-12-30

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017