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Dobutamine (Dobutamine Hydrochloride) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Increased Heart Rate, Blood Pressure, and Ventricular Ectopic Activity - A 10- to 20-mm increase in systolic blood pressure and an increase in heart rate of 5 to 15 beats/minute have been noted in most patients (see WARNINGS  regarding exaggerated chronotropic and pressor effects). Approximately 5% of pateints have had increased premature ventricular beats during infusions. These effects are dose related.

Hypotension - Preciipitous decreases in blood pressure have occasionally been described in association with dobutamine therapy. Decreasing the dose or discontinuing the infusion typically results in rapid return of blood pressure to baseline values. In rare cases, however, intervention may be required and reversibility may not be immediate.

Reactions at Sites of Intravenous Infusion - Phlebitis has occasionally been reported. Local inflammatory changes have been described following inadvertent infiltration. Isolated cases of cutaneous necrosis (destruction of skin tissue) have been reported.

Miscellaneous Uncommon Effects - The following adverse effects have been reported in 1% to 3% of patients: nausea, headache, anginal pain, nonspecific chest pain, palpitations, and shortness of breath.

Isolated cases of thrombocytopenia have been reported.

Administration of dobutamine, like other catecholamines, can produce a mild reduction in serum potassium concentration, rarely to hypokalemic levels (see PRECAUTIONS).

Longer-Term Safety - Infusions of up to 72 hours have revealed no adverse effects other than those seen with shorter infusions.



REPORTS OF SUSPECTED DOBUTAMINE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Dobutamine. The information is not vetted and should not be considered as verified clinical evidence.

Possible Dobutamine side effects / adverse reactions in 46 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-30

Patient: 46 year old male

Reactions: Eosinophilic Myocarditis, Cardiogenic Shock

Adverse event resulted in: hospitalization

Suspect drug(s):
Acetaminophen and Tramadol HCL
    Dosage: unk
    Administration route: Oral
    Indication: Pain
    End date: 2012-07-01

Aldactone
    Dosage: 50 mg, daily
    Administration route: Oral
    End date: 2012-07-01

Bisoprolol Fumarate
    Dosage: 2.5 mg, daily
    Administration route: Oral
    End date: 2012-07-01

Corotrope
    Dosage: unk
    Indication: Ejection Fraction Decreased
    Start date: 2012-06-06
    End date: 2012-07-01

Dobutamine
    Dosage: unk
    Indication: Ejection Fraction Decreased
    Start date: 2012-06-06

Imovane
    Dosage: unk
    Administration route: Oral
    End date: 2012-07-01

Lasix
    Dosage: 40 mg, daily
    Administration route: Oral
    End date: 2012-07-01

Procoralan
    Dosage: 7.5 mg, 2x/day
    Administration route: Oral
    End date: 2012-07-01



Possible Dobutamine side effects / adverse reactions in 73 year old female

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-02

Patient: 73 year old female

Reactions: Cardiogenic Shock

Adverse event resulted in: hospitalization

Suspect drug(s):
Dobutamine
    Indication: Septic Shock

Dopamine HCL
    Indication: Septic Shock

Nitroglycerin
    Indication: Angina Pectoris



See index of all Dobutamine side effect reports >>

Drug label data at the top of this Page last updated: 2014-10-15

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