DOSAGE AND ADMINISTRATION
Each dose of aspirin should be taken with a full glass of water unless patient is fluid restricted. Anti-inflammatory and analgesic dosages should be individualized. When aspirin is used in high doses, the development of tinnitus may be used as a clinical sign of elevated plasma salicylate levels except in patients with high frequency hearing loss.
Ischemic Stroke and TIA: 50-325 mg once a day. Continue therapy indefinitely.
Suspected Acute MI: The initial dose of 160-162.5 mg is administered as soon as an MI is suspected. The maintenance dose of 160-162.5 mg a day is continued for 30 days post infarction. After 30 days, consider further therapy based on dosage and administration for prevention of recurrent MI.
Prevention of Recurrent MI: 75-325 mg once a day. Continue therapy indefinitely.
Unstable Angina Pectoris: 75-325 mg once a day. Continue therapy indefinitely.
Chronic Stable Angina Pectoris: 75-325 mg once a day. Continue therapy indefinitely.
CABG: 325 mg daily starting 6 hours post-procedure. Continue therapy for 1 year post-procedure.
PTCA: The initial dose of 325 mg should be given 2 hours pre-surgery. Maintenance dose is 160-325 mg daily. Continue therapy indefinitely.
Carotid Endarterectomy: Doses of 80 mg once daily to 650 mg twice daily, started presurgery, are recommended. Continue therapy indefinitely.
Rheumatoid Arthritis: The initial dose is 3 g a day in divided doses. Increase as needed for anti-inflammatory efficacy with target plasma salicylate levels of 150-300 mcg/mL. At high doses (i.e., plasma levels of greater than 200 mg/mL), the incidence of toxicity increases.
Juvenile Rheumatoid Arthritis: Initial dose is 90-130 mg/kg/day in divided doses. Increase as needed for anti-inflammatory efficacy with target plasma salicylate levels of 150-300 mcg/mL. At high doses (i.e., plasma levels of greater than 200 mg/mL), the incidence of toxicity increases.
Spondyloarthropathies: Up to 4 g per day in divided doses.
Osteoarthritis: Up to 3 g per day in divided doses.
Arthritis and Pleurisy of SLE: The initial dose is 3 g a day in divided doses. Increase as needed for anti-inflammatory efficacy with target plasma salicylate levels of 150-300 mcg/mL. At high doses (i.e., plasma levels of greater than 200 mg/mL), the incidence of toxicity increases.
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