Elocon (Mometasone Furoate Topical) - Summary

ELOCON SUMMARY

ELOCON (mometasone furoate) Cream, 0.1% contains mometasone furoate for topical use. Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity.

ELOCON ^® Cream is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 2 years of age or older.

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NEWS HIGHLIGHTS

Published Studies Related to Elocon (Mometasone Furoate Topical)

Effects of inhaled mometasone furoate on growth velocity and adrenal function: a placebo-controlled trial in children 4-9 years old with mild persistent asthma. [2011.10]
OBJECTIVE: To assess the effects of long-term mometasone furoate delivered via a dry powder inhaler (MF-DPI) on growth velocity and hypothalamic-pituitary-adrenal axis function in children with asthma... CONCLUSIONS: One year of treatment with a total daily dose of 100 mug of MF-DPI in the morning resulted in no significant difference, whereas a total daily dose of 200 mug of MF-DPI was associated with some changes in growth velocity when compared with placebo. The differences in growth velocity, and the absence of drug-related cortisol effects, support the use of a total daily dose of 100 mug of MF-DPI in children aged 4-9 years with mild persistent asthma.

Dysphagia and quality of life may improve with mometasone treatment in patients with eosinophilic esophagitis: a pilot study. [2011.10]
OBJECTIVE: The treatment of adult patients with eosinophilic esophagitis remains challenging. The aim was to assess dysphagia and health-related quality of life (HRQL) using validated scales and questionnaires before and after treatment with mometasone furoate... CONCLUSION: The dysphagia and impaired HRQL found in untreated patients with eosinophilic esophagitis improved significantly after 2 months of mometasone furoate treatment. A randomized placebo-controlled trial is warranted to assess causality. The scales and questionnaires used are sensitive instruments appropriate for symptom surveillance in individuals with eosinophilic esophagitis.

Application of mometasone spray to reduce sore throat after tracheal intubation. [2011.08]
CONCLUSION: Application of mometasone spray reduces postoperative sore throat after tracheal intubation.

The efficacy and tolerability of inhaled montelukast plus inhaled mometasone compared with mometasone alone in patients with chronic asthma. [2011.06]
BACKGROUND: The efficacy of oral montelukast in chronic asthma is well established. Montelukast is also an effective adjunctive therapy to inhaled corticosteroids (ICS) in asthma uncontrolled on ICS alone. Inhaled montelukast was recently shown to provide significant bronchodilation compared with placebo in patients with chronic asthma. The purpose of this study was to evaluate the efficacy of inhaled montelukast added to inhaled mometasone... CONCLUSION: Inhaled montelukast plus inhaled mometasone was significantly more effective than placebo plus inhaled mometasone in improving FEV(1), symptoms, asthma control, and blood eosinophil count.

Mometasone furoate effect on acute skin toxicity in breast cancer patients receiving radiotherapy: a phase III double-blind, randomized trial from the North Central Cancer Treatment Group N06C4. [2011.04.01]
CONCLUSION: Patients receiving daily MMF during radiotherapy might experience reduced acute skin toxicity compared with patients receiving placebo. Copyright (c) 2011 Elsevier Inc. All rights reserved.

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Clinical Trials Related to Elocon (Mometasone Furoate Topical)

A Study of Mometasone Furoate Nasal Spray in Perennial Allergic Rhinitis (Study P03748)(COMPLETED) [Completed]
This is a multicenter, randomized, double-blind within the dose level, parallel group comparison of mometasone furoate nasal spray in subjects with perennial allergic rhinitis to examine the minimal effective dose, the recommended dose, and the dosing regimen.

Acute Effect of Mometasone on Beta-adrenergic Airway and Airway Vascular Relaxation in Severe Asthma [Completed]
Glucocorticosteroids inhibit the disposal of organic cations by blocking organic cation transporters expressed by non-neuronal cells, thereby interfering with the inactivation of the organic cations by intracellular enzymes. Beta2-adrenergic agonists are organic cations, and the concentration of inhaled beta2-adrenergic agonists at beta2-adrenergic receptor sites on smooth muscle is likely to be increased by inhaled glucocorticosteroids (ICS) by the ICS' effect on the glucocorticosteroid-sensitive organic cation transporters. The investigators have shown in human airway vascular smooth muscle cells that the glucocorticosteroid action on organic cation uptake occurs within minutes, does not involve gene transcription or protein synthesis, is not mediated through classical steroid receptors, and is cell membrane-linked. In the present proposal, the investigators wish to use different single doses of mometasone, a clinically effective ICS, administered with or at different times before albuterol inhalation in subjects with moderate persistent asthma who are obstructed at the time of study. With this approach the investigators will test the hypothesis that a single inhalation of mometasone causes an acute, transient, dose-dependent potentiation of beta2-adrenergic bronchodilation. If the hypothesis that a single dose of mometasone acutely potentiates beta2-adrenergic bronchodilation is correct, the results would have a significant impact on treatment strategies involving ICSs and beta2-adrenergic agonists in patients with asthma.

Intranasal Mometasone in Children With Obstructive Sleep Apnea Due to Adenotonsillar Hypertrophy [Withdrawn]
Obstructive sleep apnea (OSA) in children is a disorder of breathing during sleep characterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction (obstructive apnea) that disrupts normal breathing during sleep1. The condition occurs in 2-5% of children and can occur at any age, but it is most common in children between the ages of 2 to 62,3. Untreated OSA is associated with lung disease, heart disease, growth delay, poor learning and behavioral problems such as inattention and hyperactivity. The most common underlying risk factor for the development of OSA is enlargement of tonsils and adenoids. Given the potential risk of complications associated with surgery of the tonsils and adenoids, medications to shrink the adenoids without requiring surgery have been considered, in particular intranasal corticosteroids (INCSs) which is a nose spray. A recent Cochrane systematic review suggested a short-term benefit of INCSs in children with mild to moderate OSA4. The authors recommended that further randomised controlled studies were required to evaluate the efficacy of INCSs in children with OSA. In particular they recommended that future studies should employ sleep studies to look for any improvement with INCSs, and should include children with more severe OSA, as these are the patients at the greatest risk of complications of surgery and would benefit most from a non-surgical treatment. The purpose of this study is therefore to explore the efficacy of INCSs in children with the full spectrum of OSA severity, including sleep study analysis., and longer term follow-up.

A Comparative Study of Mometasone Furoate Nasal Spray and Fluticasone Propionate Nasal Spray in Patients With Perennial Allergic Rhinitis (Study P04512) [Completed]
This study was conducted to see if mometasone nasal spray is efficaceous for the treatment of perennial allergic rhinitis. Patients will be randomized to active mometasone, placebo mometasone, active fluticasone, or placebo fluticasone.

Asthma Study Comparing Anti-Inflammatory Effects of 3 Doses of Mometasone Furoate/Formoterol Fumarate and Medium Dose Mometasone Furoate (Study P05122 AM1)(COMPLETED) [Completed]
This is a 2-week double-blind, placebo-controlled, parallel group study comparing the anti-inflammatory effects of low, medium, and high dose mometasone furoate/formoterol fumarate (MF/F) metered dose inhaler (MDI) formulation and medium dose mometasone furoate (MF) dry powder inhaler (DPI) and MDI formulations in adults and adolescents with persistent allergic asthma.

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Reports of Suspected Elocon (Mometasone Furoate Topical) Side Effects

Loss of Consciousness (5),  Drug Ineffective (3),  Erectile Dysfunction (3),  Loss of Libido (3),  Eye Pruritus (3),  Paraesthesia (3),  Burning Sensation (3),  Skin Exfoliation (2),  Urinary Incontinence (2),  Sensory Loss (2), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Elocon review by care giver of 3 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		eczema
Dosage & duration:		pea size (dosage frequency: once a day) for the period of 2 weeks and as soon as simptoms reappear
Other conditions:		no other conditions
Other drugs taken:		no other drugs were taken
		Reported Results
Benefits:		simptoms disappeared promptly.
Side effects:		None were noticed
Comments:		The child had this condition for more than 2 years.Her simptoms were quite severe During this time other treatments were administered, but without success. As soon as we started using Elocon the skin improved and after 2-3 weeks it cleared. Eczema didn't go away completely until the child was about 4. As soon as simptoms would reappear Elocon was used, but no more than once or twice at a time. The child is now 5 years old and no eczema on sight, thank God.

Elocon review by 44 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		Dermatitis
Dosage & duration:		apply to affected area (dosage frequency: once or twice daily) for the period of aprox. 3 months on and off
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Elocon is definetely a very effective drug for treating dermatitis. It clears up the condition in 4 or 5 days. See next for side effects.
Side effects:		Eventhough Elocon is effective in treating dermatitis, if used for extended periods it can cause "steroid induced rosacea" and that can become difficult to treat as it does not clear up on its own.
Comments:		After the dermatitis cleared up, I developed a rosacea that lasted for about 4 months. I had to take oral antibiotics for an extended period of time to clear up the rosacea caused by the Elocon. In summary, a very effective drug but must be used carefully and under strict medical supervision.

Elocon review by 44 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		Dermatitis
Dosage & duration:		apply to affected area (dosage frequency: once or twice daily) for the period of aprox. 3 months on and off
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Elocon is definetely a very effective drug for treating dermatitis. It clears up the condition in 4 or 5 days. See next for side effects.
Side effects:		Eventhough Elocon is effective in treating dermatitis, if used for extended periods it can cause "steroid induced rosacea" and that can become difficult to treat as it does not clear up on its own.
Comments:		After the dermatitis cleared up, I developed a rosacea that lasted for about 4 months. I had to take oral antibiotics for an extended period of time to clear up the rosacea caused by the Elocon. In summary, a very effective drug but must be used carefully and under strict medical supervision.