DRUG INTERACTIONS
Drug Interactions:
EMLA Cream should be used with caution in patients
receiving Class I antiarrhythmic drugs (such as tocainide and
mexiletine) since the toxic effects are additive and potentially
synergistic.
Prilocaine may contribute to
the formation of methemoglobin in patients treated with
other drugs known to cause this condition
(see
Methemoglobinemia
subsection of
WARNINGS
).
Specific interaction studies with lidocaine/prilocaine
and class III anti-arrhythmic drugs (eg, amiodarone, bretylium,
sotalol, doetilide) have not been performed, but caution is
advised (see
WARNINGS
).
Should EMLA Cream be used concomitantly with other
products containing lidocaine and/or prilocaine, cumulative
doses from all formulations must be considered.
|