DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Esidrix (Hydrochlorothiazide) - Indications and Dosage




In the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.


As adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.

      Esidrix has also been found useful in edema due to various forms of renal dysfunction, such as the nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

      Usage in Pregnancy: The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.

      Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy (however, see PRECAUTIONS, Pregnancy). Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is not harmful to either the fetus or the mother (in the absence of cardiovascular disease) but which is associated with edema, including generalized edema, in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort which is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate.


Therapy should be individualized according to patient response.

      Dosage should be titrated to gain maximal therapeutic response as well as the minimal dose possible to maintain that therapeutic response.



To Initiate Therapy: Usual dosage is 50-100 mg daily. May be given as a single dose every morning.

      Maintenance: After a week dosage may be adjusted downward to as little as 25 mg a day, or upward. Rarely patients may require up to 200 mg daily in divided doses.

      Combined Therapy: When necessary, other antihypertensive agents may be added cautiously. Since this drug potentiates the antihypertensive effect of other agents, such additions should be gradual. Dosages of ganglionic blockers in particular should be halved initially.


To Initiate Diuresis: 25 to 200 mg daily for several days, or until dry weight is attained.

      Maintenance: 25 to 100 mg daily or intermittently depending on the patient’s response. A few refractory patients may require up to 200 mg daily.


The usual pediatric dosage is administered twice daily.

      The total daily dosage for infants up to 2 years of age: 12.5 to 37.5 mg; for children 2 to12 years of age: 37.5 to100 mg. Dosages should be based on body weight at the rate of 1 mg per pound, but infants below 6 months of age may require 1.5 mg per pound.


Tablets 25 mg – round, pink, scored (imprinted CIBA 22)

      Bottles of 100........................................... NDC 0083-0022-30

Tablets 50 mg – round, yellow, scored (imprinted CIBA 46)

      Bottles of 100........................................... NDC 0083-0046-30

Do not store above 86ºF (30ºC).

Dispense in tight, light-resistant container (USP).


C96-27 (Rev. 3/96)


Ciba-Geigy Corporation

Pharmaceuticals Division

Summit, New Jersey 07901

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017