Flomax (Tamsulosin Hydrochloride) - Summary

FLOMAX SUMMARY

Tamsulosin hydrochloride is an antagonist of alpha_1A adrenoceptors in the prostate.

Flomax^® (tamsulosin hydrochloride) capsules are indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). FLOMAX capsules are not indicated for the treatment of hypertension.

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NEWS HIGHLIGHTS

Media Articles Related to Flomax (Tamsulosin)

Benign Prostatic Hyperplasia (Enlarged Prostate) Quiz
Source: MedicineNet Benign Prostatic Hyperplasia Specialty [2017.09.20]
Title: Benign Prostatic Hyperplasia (Enlarged Prostate) Quiz
Category: MedicineNet Quiz
Created: 2/7/2012 3:29:00 PM
Last Editorial Review: 9/20/2017 12:17:12 PM

Enlarged Prostate (BPH, Benign Prostatic Hyperplasia)
Source: MedicineNet Blood In Urine Specialty [2017.05.18]
Title: Enlarged Prostate (BPH, Benign Prostatic Hyperplasia)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 5/18/2017 12:00:00 AM

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Published Studies Related to Flomax (Tamsulosin)

Effectiveness of tamsulosin in prevention of post-operative urinary retention: a randomized double-blind placebo-controlled study. [2014]
tamsulosin with placebo on postoperative urinary retention... CONCLUSIONS: This study suggests that short perioperative treatment with

Effectiveness of tamsulosin in prevention of post-operative urinary retention: a randomized double-blind placebo-controlled study. [2014]
tamsulosin with placebo on postoperative urinary retention... CONCLUSIONS: This study suggests that short perioperative treatment with

The effect of udenafil on the hemodynamics of healthy male volunteers administered tamsulosin. [2013]
between udenafil and tamsulosin... CONCLUSION: The coadministration of udenafil and tamsulosin was not associated

Urodynamic effects of the combination of tamsulosin and daily tadalafil in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia: a randomized, placebo-controlled clinical trial. [2013]
study (UDS)... CONCLUSIONS: The association of tamsulosin/tadalafil reduces detrusor pressure at

Tamsulosin for the management of distal ureteral stones in children: A prospective randomized study. [2011.11.16]
PURPOSE: Based on efficacy demonstrated in the adult population, tamsulosin was evaluated with regard to facilitating ureteral stone expulsion in children presenting with distal ureteric calculi... CONCLUSIONS: Medical expulsion therapy for lower ureteric stones is a successful procedure in children. Tamsulosin demonstrated no clinically significant adverse effect, while proving to be a safe and effective treatment option. Copyright (c) 2011 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

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Clinical Trials Related to Flomax (Tamsulosin)

Efficacy of Flomax to Improve Stone Passage Following Shock Wave Lithotripsy [Terminated]
The majority of kidney stones are treated with shock wave lithotripsy (SWL). We are examining if the medication Flomax will result in improved stone passage rates following SWL.

Study to Evaluate the Effect of Solifenacin and Mirabegron on the Tamsulosin Hydrochloride (HCl) Concentrations in Blood in Healthy Male Subjects [Completed]
The purpose of this study is to evaluate the effect of solifenacin and mirabegron on the concentrations of tamsulosin HCl after combined dosing. This study will also evaluate the safety and tolerability of the combined administration of solifenacin, mirabegron and tamsulosin HCl.

Solifenacin Succinate With Tamsulosin HCl in Males With Lower Urinary Tract Symptoms and Bladder Outlet Obstruction [Completed]
A study to evaluate the safety of the co-administration of solifenacin succinate with tamsulosin hydrochloride in men with lower urinary tract symptoms (LUTS) and bladder outlet obstruction (BOO).

Silodosin Versus Tamsulosin for Treatment of Ureteral Stones [Terminated]
Ureteral calculi, commonly known as kidney stones, are a frequent cause of Emergency Department (ED) visits. These stones can get caught in the ureter (the tube connecting the kidney to the bladder) and cause symptoms including pain, nausea, and vomiting. As long as the obstructing stone meets certain conditions and the patient isn't too sick, the patient is usually sent home to try and pass the stone without surgery. This treatment is known as medical expulsive therapy (MET), and routinely involves the use of a drug called tamsulosin, which relaxes the smooth muscle of the urinary system to help the stone pass. Silodosin is a drug in the same class of tamsulosin, but which is thought to have a more selective action and a quicker onset, which would theoretically make it better for aiding in kidney stone passage. The purpose of this study is a head-to-head, blinded comparison of these two drugs to see how quickly they result in stone passage. Subjects are patients presenting to the ED with acute kidney stone shown by CT scan, and who are appropriate for MET. The main study intervention is randomization to receiving either tamsulosin or silodosin. The hypothesis is that silodosin will have decreased time to stone passage compared to tamsulosin. Subjects who qualify and consent are randomized to a two-week course of either silodosin or tamsulosin. They are also given prescriptions for standard of care medications for pain and nausea, as well as a pain diary. They receive a follow-up phone call after one week to remind them of their follow-up appointment, ask about adverse events, and determine if their stone has passed. They have a follow-up visit with study staff at the end of their two week treatment to collect their pain diary, pill count, adverse events, and to determine if their stone has passed. Study participation ends after this follow-up visit.

Bioavailability of Two Combination Products of Dutasteride (0.5mg) and Tamsulosin Hydrochloride (0.2mg) in Asian Males. [Completed]
This study aims to determine the relative bioavailability of tamsulosin hydrochloride in a fixed dose combination capsule of dutasteride and tamsulosin hydrochloride (0. 5 mg/0. 2 mg) relative to co-administration of dutasteride 0. 5 mg capsules and tamsulosin hydrochloride 0. 2 mg tablets or capsules. Two fixed dose combination capsules will be tested; one will contain tamsulosin hydrochloride pellets with a 15% enteric coating, and the other tamsulosin hydrochloride pellets with a 10% enteric coat. In addition, two formulations of tamsulosin hydrochloride will be tested in the co-administration with dutasteride 0. 5 mg; a 0. 2 mg oral disintegrating tablet and a 0. 2 mg hard shell capsule. This will be an open-label, randomized, single dose, four-period crossover in healthy male subjects of North East Asian ancestry. Subjects will receive single oral doses in four treatment periods, each separated by a 5-10 day washout period. Blood samples for pharmacokinetic analysis will be taken at regular intervals after dosing. Safety will be assessed by measurement of blood pressure, heart rate and review of adverse events. The study will enrol approximately 30 healthy male subjects to ensure that 24 complete the study.

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Reports of Suspected Flomax (Tamsulosin) Side Effects

Dizziness (24),  Anxiety (15),  Insomnia (15),  Drug Ineffective (14),  Rash (14),  Arthralgia (14),  Sexual Dysfunction (14),  Hypertension (14),  Pain (13),  Fatigue (13), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Flomax review by 59 year old male patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		frequent urination
Dosage & duration:		2 tab per day taken every day for the period of every day
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Was getting up to urinate 3-6 times a night to urinate. NOw can sleep through the night getting up not at all or one time. excellent results - could not be happier. Dr. did digital exam, but felt no abnormality, but said hypertrophy could be on side he could not palpate, so to try tamsulosin. It worked!
Side effects:		I did not experience any side effects to speak of
Comments:		took as prescribe. I started off with one capsule per day, then, as soon as possible, went to two capsules per day. Two capsules per day did the trick. Am able to sleep through the night the majority of the time!

Flomax review by 48 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		kidney pain, difficult urination
Dosage & duration:		0.4 milligram (mg) once a day taken once a day for the period of One week was enough
Other conditions:		Chronic Fatigue Syndrome
Other drugs taken:		Antidepressants (wellbutrin, lexapro)
		Reported Results
Benefits:		As near as we can tell, this drug (which is intended for men with enlarged prostates) relaxed ureter muscles, relieving the sensation of kidney stone pain, and also relaxed bladder muscles that had caused painful urination.
Side effects:		It made me drowsy all week; also sporadic dizziness. Chronic nasal congestion (stuffy nose) was also unpleasant.
Comments:		Once kidney stones were ruled out as the cause, the choices were to "wait it out," or to try this medication. Directions were pretty straightforward---take the pill after a meal; don't drive if feeling dizzy or drowsy; drink plenty of water.

Flomax review by 48 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		kidney pain, difficult urination
Dosage & duration:		0.4 milligram (mg) once a day taken once a day for the period of One week was enough
Other conditions:		Chronic Fatigue Syndrome
Other drugs taken:		Antidepressants (wellbutrin, lexapro)
		Reported Results
Benefits:		As near as we can tell, this drug (which is intended for men with enlarged prostates) relaxed ureter muscles, relieving the sensation of kidney stone pain, and also relaxed bladder muscles that had caused painful urination.
Side effects:		It made me drowsy all week; also sporadic dizziness. Chronic nasal congestion (stuffy nose) was also unpleasant.
Comments:		Once kidney stones were ruled out as the cause, the choices were to "wait it out," or to try this medication. Directions were pretty straightforward---take the pill after a meal; don't drive if feeling dizzy or drowsy; drink plenty of water.