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Gamimune N (Immune Globulin) - Drug Interactions, Contraindications, Overdosage, etc



Antibodies in Gamimune N, 10% may interfere with the response to live viral vaccines such as measles, mumps and rubella. Therefore, use of such vaccines should be deferred until approximately 6 months after Gamimune N, 10% administration.

Please see DOSAGE AND ADMINISTRATION for other drug interactions.


Gamimune N, 10% is contraindicated in individuals who are known to have had an anaphylactic or severe systemic response to Immune Globulin (Human). Individuals with selective IgA deficiencies who have known antibody against IgA (anti-IgA antibody) should not receive Gamimune N, 10% since these patients may experience severe reactions to the IgA which may be present.22


  1. Tenold RA, inventor; Cutter Laboratories, assignee. Intravenously injectable immune serum globulin. U.S. Patent 4,396,608, Aug. 2, 1983.
  2. Data on file at Bayer Corporation.
  3. Pirofsky B, Campbell SM, Montanaro A: Individual patient variations in the kinetics of intravenous immunoglobulin administration. J Clin Immunol 2(2): 7S-14S, 1982.
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  5. Pirofsky B, Anderson CJ, Bardana EJ Jr.: Therapeutic and detrimental effects of intravenous immunoglobulin therapy. In: Alving BM (ed.): Immunoglobulins: characteristics and uses of intravenous preparations. Washington, D.C., U.S. Government Printing Office, (1980), pp 15-22.
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  10. Pahwa S, Fikrig S, Menez R, et al: Pediatric acquired immunodeficiency syndrome demonstration of B-lymphocyte defects in vitro. Diagn Immunol 4(1):24-30, 1986.
  11. Bernstein LJ, Krieger BZ, Novick B, et al: Bacterial infections in the acquired immunodeficiency syndrome of children. Pediatr Infect Dis 4(5):472-5, 1985.
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  14. Mofenson LM, Willoughby A. Passive immunization. In: Pizzo PA, Wilfert CM, (eds.) Pediatric AIDS: the challenge of HIV infection in infants, children and adolescents. Baltimore: Williams & Wilkins (1991) pp 633-50.
  15. National Institute of Child Health and Human Development Intravenous Immunoglobulin Study Group. Intravenous immune globulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection. N Engl J Med 325(2):73-80, 1991.
  16. Mofenson LM, Moye J Jr, Bethel J, et al: Prophylactic intravenous immunoglobulin in HIV-infected children with CD4 + counts of 0.20 × 109/L or more. Effect on viral, opportunistic, and bacterial infections. JAMA 268(4):483-88, 1992.
  17. Glycine. In: Budavari S, O'Neil MJ, Smith A, et al, eds.: Merck Index. 11th ed. Rahway NJ, Merck & Co., 1989. p. 706.
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  21. Nolte MT, Pirofsky B, Gerritz GA, et al: Intravenous immunoglobulin therapy for antibody deficiency. Clin Exp Immunol 36: 237-43, 1979.
  22. Buckley RH: Immunoglobulin replacement therapy: indications and contraindications for use and variable IgG levels achieved. In: Alving BM (ed): Immunoglobulins: characteristics and uses of intravenous preparations. Washington, D.C., U.S. Government Printing Office, (1980), pp 3-8.
  23. Ochs HD: Intravenous immunoglobulin therapy of patients with primary immunodeficiency syndromes: efficacy and safety of a new modified immune globulin preparation. In: Alving BM (ed.): Immunoglobulins: characteristics and uses of intravenous preparations. Washington, D.C., U.S. Government Printing Office, (1980), pp 9-14.
  24. Cayco AV, Perazella MA, Hayslett JP: Renal insufficiency after intravenous immune globulin therapy: A Report of Two Cases and an Analysis of the Literature. J Amer Soc Nephrology 8:1788-1793, 1997.
  25. Sekul E, Cupler E, Dalakas M. Aseptic meningitis associated with high-dose intravenous immunoglobulin therapy: Frequency and risk factors. Ann Int Med 121:259-262, 1994.
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  27. Casteels-Van Daele M, Wijndaele L, Hunninck K, et al: Intravenous immune globulin and acute aseptic meningitis. N Engl J Med 323(9):614-615, 1990.
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  29. Schiavotto C, Ruggeri M. Rodeghiero F. Adverse reactions after high-dose intravenous immunoglobulin: incidence in 83 patients treated for idiopathic thrombocytopenic purpura (ITP) and review of the literature. Haematologica 78(6:Suppl 2):35-40, 1993.
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Bayer Corporation

Pharmaceutical Division

Elkhart, IN 46515 USA 08692249

U.S. License No. 8 (Rev. November 2001)

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