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Guaifenesin NR Liquid (Guaifenesin) - Description and Clinical Pharmacology

 
 



DESCRIPTION

Guaifenesin NR syrup is an expectorant available in liquid form for oral administration.Each 5 mL (1 teaspoonful) contains: Guaifenesin 100 mg.

INACTIVE INGREDIENTS: Caramel, Citric Acid, Flavor, Glycerin, Propylene Glycol, Saccharin Sodium, Sodium Benzoate, Sorbitol Solution, Water. It may contain Sodium Citrate.

Guaifenesin (glyceryl guaiacolate) has the chemical name 3-(2-methoxyphenoxy)-1,2-propanediol. Its molecular formula is C10H14O4, with a molecular weight of 198.21. It is a white, colorless crystalline substance with a slightly bitter aromatic taste. One gram dissolves in 20 mL water at 25°C; freely soluble in ethanol. Guaifenesin is readily absorbed from the gastro-intestinal tract and is rapidly metabolized and excreted in the urine. Guaifenesin has a plasma half-life of one hour. The major urinary metabolite is beta-(2-methoxyphenoxy) lactic acid.

CLINICAL PHARMACOLOGY

Guaifenesin is an expectorant, the action of which promotes or facilitates the removal of secretions from the respiratory tract. By increasing sputum volume and making sputum less viscous, guaifenesin facilitates expectoration of retained secretions.

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