HEPATAMINE SUMMARY
HepatAmine (8% Amino Acid Injection) is a sterile, nonpyrogenic, hypertonic solution containing crystalline amino acids. A 500 mL unit provides a total of 40 g of amino acids and 6 g of nitrogen (38 g of protein equivalent).
HepatAmine is indicated for the treatment of hepatic encephalopathy in patients with cirrhosis or hepatitis. HepatAmine provides nutritional support for patients with these diseases of the liver who require parenteral nutrition and are intolerant of general purpose amino acid injections, which are contraindicated in patients with hepatic coma.
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NEWS HIGHLIGHTS
Published Studies Related to Hepatamine (Amino Acid Injection)
Results of a phase I study in patients suffering from secondary-progressive multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301 and a possible induction of an anti-inflammatory cytokine response. [2010.08.25]
PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS... MRI data indicated a non-significant trend for a reduction of lesion numbers in subjects treated with 1 and 3 mg PI-2301.
Results of a phase I study in patients suffering from secondary-progressive
multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301
and a possible induction of an anti-inflammatory cytokine response. [2010]
PI-2301 is an immunomodulator that could be an alternative therapy for MS. A
placebo-controlled, multiple-ascending dose, double-blind study was performed in
patients with secondary-progressive MS... The most common adverse event was transient injection site reactions.
Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies. [2009.12]
RATIONALE: Dimethylaminoethanol pyroglutamate (DMAE p-Glu) is a compound resulting from the reaction between dimethylaminoethanol (an indirect precursor of acetylcholine) and pyroglutamic acid (a cyclic derivative of glutamic acid having procholinergic properties and promnesic effects in both animals and man). OBJECTIVES: The present study undertook preclinical and clinical evaluations to test a potential therapeutic utility for DMAE p-Glu in cognitive impairments related to central cholinergic deficit... CONCLUSION: These results indicate that DMAE p-Glu reduces the deleterious effect of scopolamine on long-term memory in healthy volunteers and suggest that DMAE p-Glu might be effective in reducing memory deficits in patients with cognitive impairment.
Clinical Trials Related to Hepatamine (Amino Acid Injection)
Dietary Intake and Circulating Levels of Branched Chain Amino Acids [Completed]
The investigators are conducting this research study to find out if eating low or high
levels of specific amino acids changes the levels of these same amino acids in the blood.
Amino acids are the building blocks of protein that are normally found in food. The amino
acids the investigators are studying are called branched chain amino acids. The
investigators will look at the levels (amount) of branched chain amino acids in blood before
and after consumption of specially prepared meals. The investigators hypothesize that
circulating branch chain amino acid (BCAA) levels will be lower following a low BCAA-content
diet compared with a high BCAA-content diet.
Total Parenteral Nutrition Associated Cholestasis (TPNAC) and Plasma Amino Acid Levels in Neonates [Enrolling by invitation]
The purpose of this study is to analyze if the infants who received Primene solution, have
lower serum levels of methionine and cysteine and higher serum levels of taurine, we also
analyze if the infants who received Primene solution develop TPN-associated cholestasis in a
smaller proportion than those who received Trophamine solution.
Gut Hormones After Oral Versus Intravenous Amino Acids [Completed]
The study hypothesis is that gut hormones are released after oral but not intravenous amino
acids which result in stimulation of insulin secretion.
Exercise and Branched Chain Amino Acids (BCAA)Requirements in Older Men [Not yet recruiting]
Likely, branched chain amino acid (BCAA) requirements are increased in older
strength-trained (ST) individuals. If so, supplementation in this group will maximize muscle
protein synthesis (MPS) and minimize loss of muscle with age (sarcopenia).
Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle [Recruiting]
This study has two protocols the aims of which are:
1. To identify age-related effects of AA on incretin secretion and whether and to what
extent AA exhibit a true incretin effect (gut- mediated increases in plasma insulin) in
younger individuals. (Protocol 1)
2. To define the extra-pancreatic ''novel'', insulin independent effects of glucagon like
peptide-1 (GLP-1) on postprandial muscle protein and glucose metabolism and
microvascular blood flow. (Protocol 2)
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