ADVERSE REACTIONS
The major hazards of hydromorphone hydrochloride tablets include respiratory depression and apnea. To a lesser degree, circulatory depression, respiratory arrest, shock and cardiac arrest have occurred.
The most frequently observed adverse effects are light-headedness, dizziness, sedation, nausea, vomiting, sweating, flushing, dysphoria, euphoria, dry mouth, and pruritus. These effects seem to be more prominent in ambulatory patients and in those not experiencing severe pain.
Less Frequently Observed Adverse Reactions
General and CNS – Weakness, headache, agitation, tremor, uncoordinated muscle movements, alterations of mood (nervousness, apprehension, depression, floating feelings, dreams), muscle rigidity, paresthesia, muscle tremor, blurred vision, nystagmus, diplopia and miosis, transient hallucinations and disorientation, visual disturbances, insomnia, increased intracranial pressure
Cardiovascular – Flushing of the face, chills, tachycardia, bradycardia, palpitation, faintness, syncope, hypotension, hypertension
Respiratory – Bronchospasm and laryngospasm
Gastrointestinal – Constipation, biliary tract spasm, ileus, anorexia, diarrhea, cramps, taste alteration
Genitourinary – Urinary retention or hesitancy, antidiuretic effects
Dermatologic – Urticaria, other skin rashes, diaphoresis.
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REPORTS OF SUSPECTED HYDROMORPHONE SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Hydromorphone. The information is not vetted and should not be considered as verified clinical evidence.
Possible Hydromorphone side effects / adverse reactions in 25 year old female
Reported by a physician from United States on 2011-12-22
Patient: 25 year old female
Reactions: Completed Suicide
Adverse event resulted in: death
Suspect drug(s):
Acetaminophen and Hydrocodone Bitartrate
Administration route: Oral
Alprazolam
Administration route: Oral
Acetaminophen
Administration route: Oral
Lorazepam
Administration route: Oral
Hydromorphone
Administration route: Oral
Possible Hydromorphone side effects / adverse reactions in 19 year old female
Reported by a physician from United States on 2012-01-04
Patient: 19 year old female
Reactions: Intentional Overdose, Completed Suicide
Adverse event resulted in: death
Suspect drug(s):
Acetaminophen
Hydrocodone
Hydromorphone
Ibuprofen
Dosage: 200 mg (max 500 tablets)
Administration route: Oral
Acetylsalicylic Acid SRT
Dosage: 325 mg (max 100 tablets)
Administration route: Oral
Acetaminophen and Hydrocodone Bitartrate
Dosage: (max 30 tablets)
Administration route: Oral
Possible Hydromorphone side effects / adverse reactions in 42 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-12
Patient: 42 year old female
Reactions: Death
Adverse event resulted in: death
Suspect drug(s):
Omeprazole
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Ondansetron
Dosage: unk
Indication: Product Used FOR Unknown Indication
Hydromorphone
Dosage: unk
Indication: Product Used FOR Unknown Indication
Amitriptyline HCL
Dosage: unk
Administration route: Oral
Verapamil HCL
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
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