DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Isoniazid (Isoniazid) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The most frequent reactions are those affecting the nervous system and the liver.
Nervous System Reactions: Peripheral neuropathy is the most common toxic effect. It is dose-related, occurs most often in the malnourished and in those predisposed to neuritis (e.g., alcoholics and diabetics) and is usually preceded by paresthesias of the feet and hands. The incidence is higher in "slow inactivators".
Other neurotoxic effects, which are uncommon with conventional doses, are convulsions, toxic encephalopathy, optic neuritis and atrophy, memory impairment, and toxic psychosis.
Hepatic Reactions: See boxed warning. Elevated serum transaminase (SGOT; SGPT), bilirubinemia, bilirubinuria, jaundice, and occasionally severe and sometimes fatal hepatitis. The common prodromal symptoms of hepatitis are anorexia, nausea, vomiting, fatigue, malaise, and weakness. Mild hepatic dysfunction, evidenced by mild and transient elevation of serum transaminase levels occurs in 10 to 20 percent of patients taking isoniazid. This abnormality usually appears in the first 1 to 3 months of treatment but can occur at any time during therapy. In most instances, enzyme levels return to normal and generally, there is no necessity to discontinue medication during the period of mild serum transaminase elevation. In occasional instances, progressive liver damage occurs, with accompanying symptoms. If the SGOT value exceeds three to five times the upper limit of normal, discontinuation of the isoniazid should be strongly considered. The frequency of progressive liver damage increases with age. It is rare in persons under 20, but occurs in up to 2.3 percent of those over 50 years of age.
Gastrointestinal Reactions: Nausea, vomiting and epigastric distress.
Hematologic Reactions: Agranulocytosis; hemolytic, sideroblastic or aplastic anemia, thrombocytopenia and eosinophilia.
Hypersensitivity Reactions: Fever, skin eruptions (morbilliform, maculopapular, purpuric or exfoliative), lymphadenopathy and vasculitis.
Metabolic And Endocrine Reactions: Pyridoxine deficiency, pellagra, hyperglycemia, metabolic acidosis and gynecomastia.
Miscellaneous Reactions: Rheumatic syndrome and systemic lupus erythematosus-like syndrome.



REPORTS OF SUSPECTED ISONIAZID SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Isoniazid. The information is not vetted and should not be considered as verified clinical evidence.

Possible Isoniazid side effects / adverse reactions in 27 year old female

Reported by a physician from South Africa on 2011-10-04

Patient: 27 year old female weighing 56.2 kg (123.6 pounds)

Reactions: Arthralgia, Tendonitis

Suspect drug(s):
Rifampin
    Indication: Pulmonary Tuberculosis
    Start date: 2011-08-15

Placebo
    Dosage: unk
    Indication: Pulmonary Tuberculosis
    Start date: 2011-08-15

Moxifloxacin
    Indication: Pulmonary Tuberculosis
    Start date: 2011-08-15

Pyrazinamide
    Indication: Pulmonary Tuberculosis
    Start date: 2011-08-15

Isoniazid
    Dosage: daily dose 300 mg
    Indication: Pulmonary Tuberculosis
    Start date: 2011-08-15



Possible Isoniazid side effects / adverse reactions in male

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-11

Patient: male

Reactions: Death, Hepatic Function Abnormal, Liver Disorder

Adverse event resulted in: death

Suspect drug(s):
Isoniazid
    Indication: Pulmonary Tuberculosis

Ethambutol Hydrochloride
    Indication: Pulmonary Tuberculosis

Levofloxacin
    Indication: Pulmonary Tuberculosis

Rifadin
    Indication: Pulmonary Tuberculosis

Ciprofloxacin
    Indication: Pulmonary Tuberculosis



Possible Isoniazid side effects / adverse reactions in 54 year old male

Reported by a pharmacist from Japan on 2011-10-12

Patient: 54 year old male

Reactions: Expressive Language Disorder

Suspect drug(s):
Ebutol
    Administration route: Oral
    Indication: Pulmonary Tuberculosis
    Start date: 2011-07-01

Isoniazid
    Administration route: Oral
    Indication: Pulmonary Tuberculosis
    Start date: 2011-07-01

Rifampin
    Dosage: unk
    Administration route: Oral
    Indication: Pulmonary Tuberculosis
    Start date: 2011-07-01



See index of all Isoniazid side effect reports >>

Drug label data at the top of this Page last updated: 2011-06-21

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017