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Kayexalate (Sodium Polystyrene Sulfonate) - Summary

 
 



KAYEXALATE SUMMARY

KAYEXALATE, brand of sodium polystyrene sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt.

KAYEXALATE is indicated for the treatment of hyperkalemia.


See all Kayexalate indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Kayexalate (Sodium Polystyrene Sulfonate)

Efficacy of the cation exchange resin, sodium polystyrene sulfonate, to decrease iron absorption. [2000]
BACKGROUND: Iron is not bound by charcoal; therefore, a method of binding iron in the gastrointestinal tract to prevent absorption in iron overdose is needed...

Glucose and insulin infusion versus kayexalate for the early treatment of non-oliguric hyperkalemia in very-low-birth-weight infants. [1999.09]
Forty very low birth weight (VLBW) infants with non-oliguric hyperkalemia in the first few days after birth were enrolled in this study. They were randomly divided into 2 groups, regular insulin (RI) infusion group and kayexalate resin enema group.

Effect of three laxatives and a cation exchange resin on fecal sodium and potassium excretion. [1995.03]
BACKGROUND/AIMS: The treatment of hyperkalemia in patients with renal insufficiency often includes the ingestion of sorbitol and a cation exchange resin. Sorbitol alone may be used to remove sodium and water from overloaded patients. The efficacy of these regimens has never been compared with other laxative or laxative-resin combinations. The aim of the study was to compare the relative effect of three laxatives with different mechanisms of action, alone and in combination with resin, on fecal sodium and potassium excretion... CONCLUSIONS: In normal people, phenolphthalein (1) is preferable to other laxatives in causing fecal sodium and potassium excretion, (2) hastens resin transit through the intestine compared with other laxatives, and (3) produces greater fecal potassium excretion when combined with resin than phenolphthalein alone or other laxative-resin combinations.

Effect of sodium polystyrene sulfonate on lithium bioavailability. [1992.11]
STUDY OBJECTIVE: To examine the effect of a single dose of sodium polystyrene sulfonate and sorbitol on lithium absorption... CONCLUSION: Sodium polystyrene sulfonate and sorbitol may be used in patients immediately or shortly after ingestion of a significant acute overdose of lithium in situations in which hemodialysis cannot be instituted promptly.

Lithium absorption prevented by sodium polystyrene sulfonate in volunteers. [1992.11]
STUDY OBJECTIVE: To determine if sodium polystyrene sulfonate prevents absorption of lithium in human beings... CONCLUSION: Sodium polystyrene sulfonate administration decreased absorption of lithium after a lithium carbonate overdose. Sodium polystyrene sulfonate may be useful clinically for gastric decontamination after lithium overdoses.

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Clinical Trials Related to Kayexalate (Sodium Polystyrene Sulfonate)

Efficacy of Sodium Polystyrene Sulfonate in the Treatment of Hyperkaliemia in Pre-dialysis Patients [Completed]
The purpose of this trial is to determine if sodium polystyrene sulfonate (SPS) is an effective treatment of mild hyperkalemia in chronic kidney disease patients followed at a pre-dialysis or nephrology outpatient clinic. Subjects will be randomized to one of two treatment arms: 30 g of placebo or SPS to be taken orally once daily for seven days. The change in serum potassium levels will be compared in both treatment groups. The proportion of subjects attaining normokalemia (3. 5 to 5. 0 mmol/L) after seven days of treatment will also be compared. Finally, side effects will be reported for each treatment arm.

Reinflation After Early Tourniquet Release in Total Knee Arthroplasty [Recruiting]
This study is aimed to determine the efficacy and the safety of the tourniquet reinflation after early tourniquet release in total knee arthroplasty, compared to the method of early deflation without reinflation. The investigators hypothesized that the reinflation after early release of the tourniquet would be effective in terms of improved visualization of the surgical field and decreased operation time and blood loss, whereas it would increase tourniquet-related complication due to longer tourniquet-use time.

Sunscreen and After-sun-lotion Protection in Polymorphic Light Eruption [Completed]
Polymorphic light eruption (PLE) is a common photodermatosis characterized by the appearance of itching, erythema, papules or vesicles on sun-exposed skin. Though etiology is unclear it is hypothesized that it is an abnormal immune response to autologous antigens generated by ultraviolet radiation (UVR). This randomized, double blinded left-right body side experimental comparison study was designed to assess the preventive effect of a sunscreen and topical DNA repair enzyme-containing after-sun lotion in PLE.

Pancreas Cancer: Molecular Profiling as a Guide to Therapy Before and After Surgery ("Personalized Medicine") [Recruiting]
See treatment pathways at http://www. mcw. edu/surgery/patientinfo/Pancreatic-Cancer-Trial. htm : In this clinical trial, if the doctor knows or suspects that a growth in the pancreas is cancer (adenocarcinoma), then a sample of the growth is tested (the test is called molecular profiling). The results of the test are used by the doctor to recommend therapy (chemotherapy and radiation therapy) that the patient will receive before having surgery to remove the adenocarcinoma. When the patient goes to surgery, the adenocarcinoma that is removed is tested again. The results of that test are used to guide the choice of therapy after surgery. The chemotherapy drugs and the radiation therapy used in this clinical trial are already approved for treatment of pancreas cancer. This trial is intended to establish which treatment is best for a specific patient, based on test results from that patient's actual adenocarcinoma. In the past, the decision as to which treatment the patient will receive was not based on testing of the actual adenocarcinoma. Hypothesis: Resectability rate, overall survival rate and progression-free survival will be superior in patients with adenocarcinoma of the pancreas who receive targeted "personalized" therapy, as compared to historical data of patients who received standard therapy.

Optimal Timing of Cord Clamping in Preterm Pregnancy Following Vaginal or Cesarean Delivery [Completed]
This is an experimental research study for pregnant women between 23 and 37 weeks age of gestation who will be having a baby sooner than term. This study is to learn if waiting 20, 40, or 60 seconds to clamp the umbilical cord after baby delivers will improve his/her outcome and overall health. Benefit to the baby may come by increasing the amount of blood in the baby's body, reducing the need for possible transfusion later, and possible prevention of other complications caused by too little blood in the baby. Possible reduction of cerebral palsy may be realized by a longer interval for cord clamping.

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Reports of Suspected Kayexalate (Sodium Polystyrene Sulfonate) Side Effects

Thrombocytopenia (12)Anaemia (12)Renal Impairment (12)Tubulointerstitial Nephritis (8)Dizziness (8)Nephropathy (8)Hypokalaemia (6)Condition Aggravated (6)Hydrocephalus (5)Cardiomyopathy (5)more >>


Page last updated: 2007-10-18

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