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Kelnor 1 / 35 (Ethynodiol Diacetate / Ethinyl Estradiol) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

7. Drug Interactions:

Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested for barbiturates, phenylbutazone, phenytoin sodium, and possibly with griseofulvin, ampicillin, and tetracyclines. Administration of troglitazone concomitantly with a combination oral contraceptive (estrogen and progestin) reduced the plasma concentrations of both hormones by approximately 30%. This could result in loss of contraceptive efficacy.

Overdosage:

Serious ill effects have not been reported following acute ingestion of large doses of oral contraceptives by young children.180, 181 Overdosage may cause nausea, and withdrawal bleeding may occur in females.

NON-CONTRACEPTIVE HEALTH BENEFITS:

The following non-contraceptive health benefits related to the use of oral contraceptives are supported by epidemiological studies that largely utilized oral contraceptive formulations containing estrogen doses exceeding 35 mcg of ethinyl estradiol or 50 mcg of mestranol.148, 149

Effects on Menses:

  • Increased menstrual cycle regularity
  • Decreased blood loss and decreased risk of iron-deficiency anemia
  • Decreased frequency of dysmenorrhea

Effects Related to Inhibition of Ovulation:

  • Decreased risk of functional ovarian cysts
  • Decreased risk of ectopic pregnancies

Effects From Long-Term Use:

  • Decreased risk of fibroadenomas and fibrocystic disease of the breast
  • Decreased risk of acute pelvic inflammatory disease
  • Decreased risk of endometrial cancer
  • Decreased risk of ovarian cancer
  • Decreased risk of uterine fibroids

CONTRAINDICATIONS:

Oral contraceptives should not be used in women who have the following conditions:

  • Thrombophlebitis or thromboembolic disorders
  • A past history of deep vein thrombophlebitis or thromboembolic disorders
  • Cerebral vascular disease, myocardial infarction, or coronary artery disease, or a past history of these conditions
  • Known or suspected carcinoma of the breast, or a history of this condition
  • Known or suspected carcinoma of the female reproductive organs or suspected estrogen-dependent neoplasia, or a history of these conditions
  • Undiagnosed abnormal genital bleeding
  • History of cholestatic jaundice of pregnancy or jaundice with prior oral contraceptive use
  • Past or present, benign or malignant liver tumors
  • Known or suspected pregnancy

REFERENCES:

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