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Ketalar (Ketamine Hydrochloride) - Summary



Ketalar (ketamine hydrochloride) is a nonbarbiturate anesthetic.

Ketalar is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. Ketalar is best suited for short procedures but it can be used, with additional doses, for longer procedures.

Ketalar is indicated for the induction of anesthesia prior to the administration of other general anesthetic agents.

Ketalar is indicated to supplement low-potency agents, such as nitrous oxide.

Specific areas of application are described in the ?CLINICAL PHARMACOLOGY ?Section.

See all Ketalar indications & dosage >>


Media Articles Related to Ketalar (Ketamine)

Can the Anesthetic Ketamine Ease Suicidal Thoughts?
Source: MedicineNet Electroconvulsive Therapy Specialty [2016.05.11]
Title: Can the Anesthetic Ketamine Ease Suicidal Thoughts?
Category: Health News
Created: 5/10/2016 12:00:00 AM
Last Editorial Review: 5/11/2016 12:00:00 AM

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Published Studies Related to Ketalar (Ketamine)

Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department. [2015]
propofol and ketamine (ketofol)... CONCLUSION: We found a similar frequency of airway and respiratory adverse events

Neurocognitive effects of ketamine and association with antidepressant response in individuals with treatment-resistant depression: a randomized controlled trial. [2015]
The glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine displays rapid antidepressant effects in patients with treatment-resistant depression (TRD); however, the potential for adverse neurocognitive effects in this population has not received adequate study...

A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study of 462 cancer survivors. [2014]
efficacy of 2% ketamine plus 4% amitriptyline (KA) cream for reducing CIPN... CONCLUSIONS: This study suggests that KA cream does not decrease CIPN symptoms in

Effects of intra-operative ketamine administration on postoperative catheter-related bladder discomfort: a double-blind clinical trial. [2014]
postoperative period when compared to placebo... CONCLUSION: Preemptive administration of IV ketamine (0.5 mg/kg) can reduce

Low-dose ketamine improves pain relief in patients receiving intravenous opioids for acute pain in the emergency department: results of a randomized, double-blind, clinical trial. [2014]
patients... CONCLUSIONS: Low-dose ketamine is a viable analgesic adjunct to morphine for the

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Clinical Trials Related to Ketalar (Ketamine)

Ketamine Associated With Morphine PCA After Total Hip Arthroplasty [Completed]
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect. We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

Ketamine on Acute Pain in Females and Males [Completed]
The purpose of the study is to determine whether equal subanesthetic doses of racemic ketamine is equally effective on females and males after surgical removal of third molars

Ketamine in Chronic Kid's (KiCK) Pain [Terminated]
This study is designed to select the most tolerable dose of oral ketamine for children with chronic pain. Children will be given either placebo or one of three dosages of oral ketamine for 2 weeks. The dosage that is most tolerable will be selected for further study.

Low Dose Ketamine for Management of Acute Severe Pain in the Emergency Department [Completed]
This study aims to address both the management and evaluation of pain. The primary aim of this study is to determine the efficacy of low dose ketamine in adults with moderate to severe pain in the emergency department as compared with parenteral opioids alone. Another aim is to examine the safety of low dose ketamine compared to opioids alone. The investigators hypothesize that low dose ketamine will result in more effective pain control than morphine alone and will not be associated with an increase in adverse events.

The Effect of Perioperative Ketamine on Acute and Chronic Pain After Major Back Surgery [Completed]
After a surgical operation, patients may suffer from chronic pain. Ketamine, a well known anesthetic acts on receptors in the spine (NMDA receptors), which are implied in the occurrence of chronic pain. The mechanism is called central sensation. It is known that Ketamine reduces immediate postoperative pain, but its effectiveness in the prevention of the chronic pain is still unknown. The investigators study will follow patients until one year after operation for the occurrence of chronic pain. The investigators hypothesis is that Ketamine reduces significantly chronic postoperative pain after major back surgery and improves patient outcome. There may be important inter-individual differences how persons react on a drug. These differences are partly determined by the genes of each individual. The investigators study includes therefore a genetic analysis. Psychological and social factors also influence the perception of pain. It is still not well understood who these "psychosocial factors" determine the appearance and perception of chronic pain. In the investigators study the investigators will therefore study these factors by questionnaires.

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Reports of Suspected Ketalar (Ketamine) Side Effects

Hydronephrosis (15)Urinary Tract Disorder (9)OFF Label USE (7)Drug Ineffective (5)Cystitis Interstitial (5)Hypersensitivity (4)Alanine Aminotransferase Increased (4)Loss of Consciousness (3)Liver Function Test Abnormal (3)Cystitis Noninfective (3)more >>

Page last updated: 2016-05-11

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