NEWS HIGHLIGHTS
Published Studies Related to Labetalol
Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy:
a randomized controlled trial. [2013] hypertensive emergency of pregnancy... CONCLUSION: As administered in this trial, oral nifedipine lowered blood pressure
Changes in fetal and maternal Doppler parameters observed during acute severe hypertension treatment with hydralazine or labetalol: a randomized controlled trial. [2011.01] We evaluated 16 pregnant women with gestational age between 20 and 32 weeks in acute severe hypertension which were randomly allocated to receive either hydralazine or labetalol. Blood pressure and Doppler ultrasound parameters from maternal uterine and fetal middle cerebral and umbilical arteries were assessed during acute severe hypertension and after treatment...
CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department. [2011] INTRODUCTION: Our purpose was to compare the safety and efficacy of food and drug administration (FDA) recommended dosing of IV nicardipine versus IV labetalol for the management of acute hypertension... CONCLUSIONS: Patients treated with nicardipine are more likely to reach the physician-specified SBP target range within 30 minutes than those treated with labetalol.
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study. [2008.07] BACKGROUND: Hypertension and tachycardia are common during fiber-optic bronchoscopy (FOB), and this may lead to cardiac ischemia. The prophylactic addition of a beta-adrenergic anatagonist might mask this response and prevent the deleterious cardiovascular effects of FOB... CONCLUSIONS: Patients undergoing FOB under adequate midazolam-alfentanil sedation do not develop excessive sympathetic drive that may lead to cardiac stress. The addition of labetalol did not confer additional benefit or risk to the patients. (ClinicalTrials.gov number, NCT00394537).
Severe hypertension in pregnancy: hydralazine or labetalol. A randomized clinical trial. [2006.09] OBJECTIVE: The objective was to compare the safety and efficacy of intravenous labetalol and intravenous hydralazine for acutely lowering blood pressure in pregnancy... CONCLUSIONS: This randomized clinical trial shows that labetalol and hydralazine fulfill the criteria required for an antihypertensive drug to treat severe hypertension in pregnancy.
Clinical Trials Related to Labetalol
Labetalol and Esmolol: Vital Signs and Post Operative Pain Management [Recruiting]
This study proposes to investigate the effects of labetalol or esmolol on managing the vital
signs (like blood pressure and heart rate) during surgery, on pain management, and on the
later recovery after surgery.
It will also assess the cost-effectiveness of Labetalol and esmolol for outpatient surgery.
Hydralazine Versus Labetalol for the Management of Hypertensive Disorders of Pregnancy [Completed]
Hypertensive crisis (defined as a systolic pressure > 160mmHg or a diastolic pressure >
110mmHg) in patients with a hypertensive disorder of pregnancy is a serious complication
with severe and even deadly consequences. The management in this population had been
studied, but no consensus has been reached with regards to which treatment is better. Our
study will compare two drugs: Hydralazine and Labetalol for the management of hypertensive
crisis.
Oral Nifedipine Versus Oral Labetalol [Recruiting]
This study's aim is to determine whether oral extended release nifedipine is superior to
oral labetolol for the management of postpartum severe hypertension, specifically time to
achieve goal blood pressure, and shortening hospital stay. Our hypothesis is that oral
extended release nifedipine is superior to oral labetolol for achieving goal blood pressure
in the postpartum period.
Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department [Completed]
Comparison of Tab.Labetalol and Tab.Nifedipine for Management of Postpartum Hypertension [Not yet recruiting]
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