Latisse (Bimatoprost Ophthalmic) - Summary

LATISSE SUMMARY

LATISSE™ (bimatoprost ophthalmic solution) 0.03% is a synthetic prostaglandin analog.

LATISSE™ (bimatoprost ophthalmic solution) 0.03% is indicated to treat hypotrichosis of the eyelashes by increasing their growth including length, thickness and darkness.

See all Latisse indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Latisse (Bimatoprost Ophthalmic)

Bimatoprost 0.03%/timolol 0.5% preservative-free ophthalmic solution versus bimatoprost 0.03%/timolol 0.5% ophthalmic solution (Ganfort) for glaucoma or ocular hypertension: a 12-week randomised controlled trial. [2014]
hypertension... CONCLUSIONS: Bimatoprost/timolol PF demonstrated non-inferiority and equivalence

Safety and efficacy of bimatoprost solution 0.03% topical application in patients with chemotherapy-induced eyelash loss. [2013]
Few dermatologic conditions carry as much anxiety and emotional distress as hair loss resulting from a disease condition such as alopecia areata or as a result of cytotoxic drug treatment, e.g., after chemotherapy... Bimatoprost was found to be well tolerated over the 1-year treatment period.

Eyelash growth in subjects treated with bimatoprost: a multicenter, randomized, double-masked, vehicle-controlled, parallel-group study. [2012]
topical administration to upper eyelid margins... CONCLUSION: Bimatoprost 0.03% was found to be effective at enhancing eyelashes in

Eyelash growth in subjects treated with bimatoprost: A multicenter, randomized, double-masked, vehicle-controlled, parallel-group study. [2011.09.05]
BACKGROUND: Bimatoprost 0.03% is associated with increased growth and prominence of eyelashes. OBJECTIVE: We sought to compare the safety and efficacy of once-daily bimatoprost 0.03% versus vehicle in increasing eyelash length, thickness, and darkness after topical administration to upper eyelid margins... CONCLUSION: Bimatoprost 0.03% was found to be effective at enhancing eyelashes in adults with a very good safety profile. Copyright (c) 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

The comparison of the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness. [2011.08]
PURPOSE: To compare the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness (CCT)... CONCLUSIONS: Topical therapy with prostaglandin analogues is associated with CCT reduction. Latanoprost, travoprost, and bimatoprost have a similar effect on CCT.

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Clinical Trials Related to Latisse (Bimatoprost Ophthalmic)

Latisse (Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo [Completed]
The primary purpose of this study is to assess efficacy and safety of Latisse (bimatoprost .03% ophthalmic solution) applied to the lateral and medial eyebrows. The primary outcome is a increase in overall eyebrow prominence as measured by at least a 1-grade increase on the Global Eyebrow Assessment (GEyA) scale, from baseline to the end of the treatment which will be day 270 period.

An Observational Study of Patients Treated With Bimatoprost 0.03% (Latisse®) for Hypotrichosis of the Eyelashes [Completed]
This is an observational study of patients treated with bimatoprost 0. 03% (Latisse®) for at least 12 months for hypotrichosis of the eyelashes.

Bimatoprost in the Treatment of Eyelash Hypotrichosis [Completed]
This study will evaluate the safety and efficacy of bimatoprost solution formulation A compared with bimatoprost solution 0. 03% (LATISSE®) and vehicle in the treatment of eyelash hypotrichosis (inadequate eyelashes).

Eyelash Growth From Application of Bimatoprost in Gel Suspension to the Base of the Eyelashes [Completed]
Objective: To determine if Lumigan (bimatoprost) causes increased lash length when used in gel suspension applied to the base of the eyelashes. Methods: Subjects recruited from the Bascom Palmer Eye Institute were screened and those who met inclusion criteria were enrolled. Each participant received two vials of gel suspension, which contained bimatoprost and normal saline, respectively, each mixed 1: 1 with GonakTM gel and labeled "right eye" and "left eye" according to randomization. The suspension was applied to the eyelashes every evening on the designated eye for 6 weeks. Lash length was measured with a caliper at enrollment, at weekly intervals during the study and at 1 and 3 months after study completion. Visual acuity, ocular symptoms, intraocular pressure and photographs were documented at these same intervals. Results: The average eyelash growth in the Lumigan group was 2. 01mm (vs. control average of 1. 13mm) which was a statistically significant difference (p=0. 009). The average intraocular pressure decreased equally in both groups (2. 14 mmHg). No change in visual acuity or iris discoloration was noted in any of the subjects. Discussion: Our data showed an increase in eyelash length with use of Lumigan in gel suspension, suggesting that it may have eyelash lengthening properties.

Safety and Efficacy Study of Bimatoprost in Japanese Patients With Eyelash Hypotrichosis [Completed]
This study will evaluate the safety and efficacy of bimatoprost solution 0. 03% compared with vehicle in Japanese adults with hypotrichosis of the eyelashes.

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Reports of Suspected Latisse (Bimatoprost Ophthalmic) Side Effects

Madarosis (135),  Wrong Technique in Drug Usage Process (112),  Drug Ineffective (112),  Ocular Hyperaemia (106),  Erythema of Eyelid (83),  Eye Pruritus (78),  Trichorrhexis (67),  Eyelids Pruritus (56),  Inappropriate Schedule of Drug Administration (52),  Eye Irritation (51), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Latisse review by 33 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		eyelash loss
Dosage & duration:		one drop brushed on eyelash base (dosage frequency: 1x per day) for the period of 3mos
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		within a month of starting treatment eyelashes started to grow thicker, longer and darker
Side effects:		had occassional slight itching after application, but not consistently so and it wasn't all that bothersome
Comments:		put one drop of product on an eyeliner brush, then brushed across each eyelid at the base of the eyelashes. applied daily

Latisse review by 55 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		sparse eyelashes
Dosage & duration:		one drop nightly (dosage frequency: nightly) for the period of 1 year
Other conditions:		high blood preassure
Other drugs taken:		lisinopril 20 mg
		Reported Results
Benefits:		For the first time in my life I had enough lashes to apply mascara to. I had tried eyelash extensions which only broke off or pulled out what few thin lashes I did have. Strip lashes were itchy and uncomfortable. I now have normal lashes. Even though I only applied it to upper lashes the lower lashes have grown longer and thicker too.
Side effects:		My upper eyelids were red and itchy for the first 4-5 weeks but that went away and I have not had a problem since. My eye exams have been normal with eye preassure normal.
Comments:		For the first 6-8 weeks I used one drop every night applied to upper lash base with a small disposable brush. After my lashes had grown in I started using it every 2-3 nights instead of every night and the lashes have stayed longer and thicker than prior to treating them.

Latisse review by 55 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		sparse eyelashes
Dosage & duration:		one drop nightly (dosage frequency: nightly) for the period of 1 year
Other conditions:		high blood preassure
Other drugs taken:		lisinopril 20 mg
		Reported Results
Benefits:		For the first time in my life I had enough lashes to apply mascara to. I had tried eyelash extensions which only broke off or pulled out what few thin lashes I did have. Strip lashes were itchy and uncomfortable. I now have normal lashes. Even though I only applied it to upper lashes the lower lashes have grown longer and thicker too.
Side effects:		My upper eyelids were red and itchy for the first 4-5 weeks but that went away and I have not had a problem since. My eye exams have been normal with eye preassure normal.
Comments:		For the first 6-8 weeks I used one drop every night applied to upper lash base with a small disposable brush. After my lashes had grown in I started using it every 2-3 nights instead of every night and the lashes have stayed longer and thicker than prior to treating them.