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Levothroid (Levothyroxine Sodium) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Adverse reactions associated with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage (see PRECAUTIONS and OVERDOSAGE). They include the following:

General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating;

Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia;

Musculoskeletal: tremors, muscle weakness;

Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest;

Respiratory: dyspnea;

Gastrointestinal: diarrhea, vomiting, abdominal cramps and elevations in liver function tests;

Dermatologic: hair loss, flushing;

Endocrine: decreased bone mineral density;

Reproductive: menstrual irregularities, impaired fertility.

Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height.

Seizures have been reported rarely with the institution of levothyroxine therapy.

Inadequate levothyroxine dosage will produce or fail to ameliorate the signs and symptoms of hypothyroidism.

Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur.



REPORTS OF SUSPECTED LEVOTHROID SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Levothroid. The information is not vetted and should not be considered as verified clinical evidence.

Possible Levothroid side effects / adverse reactions in 80 year old female

Reported by a physician from United States on 2011-12-30

Patient: 80 year old female

Reactions: Atrial Fibrillation, Hyperthyroidism

Suspect drug(s):
Levothroid
    Dosage: 88 mcg (88 mcg, 1 in 1 d), oral
    Administration route: Oral
    Indication: Thyroidectomy

Levothroid
    Dosage: 100 mcg (100 mcg, 1 in 1 d), oral
    Administration route: Oral
    Indication: Thyroidectomy
    Start date: 2009-05-01

Other drugs received by patient: Vitamin E (Vitamin E) (Vitamin E); Diltiazem (Diltiazem Hydrochloride) (Diltiazem Hydrochloride); Glucosamine (Glucosamine) (Glucosamine); Calcium (Calcium) (Calcium)



Possible Levothroid side effects / adverse reactions in 53 year old female

Reported by a physician from United States on 2012-01-13

Patient: 53 year old female

Reactions: Completed Suicide, Respiratory Arrest, Cardiac Arrest

Adverse event resulted in: death

Suspect drug(s):
Fentanyl
    Dosage: transdermal

Acetaminophen and Oxycodone HCL

Acetaminophen and Hydrocodone Bitartrate

Zolpidem

Carisoprodol

Alprazolam

Levothroid

Tolterodine Tartrate



Possible Levothroid side effects / adverse reactions in 87 year old female

Reported by a physician from United States on 2012-01-17

Patient: 87 year old female

Reactions: Completed Suicide, Respiratory Arrest, Cardiac Arrest

Adverse event resulted in: death

Suspect drug(s):
Nitroglycerin

Colchicine

Metoprolol Succinate Extended Release

Hydralazine HCL

Levothroid

Zolpidem

Alprazolam

Acetaminophen/propoxyphene (Acetaminophen, Propoxyphene)



See index of all Levothroid side effect reports >>

Drug label data at the top of this Page last updated: 2012-03-02

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