LIDEX-E SUMMARY
LIDEX-E®
(fluocinonide)
Cream 0.05%
LIDEX-E® (fluocinonide) Cream 0.05% is intended for topical administration. The active component is the corticosteroid fluocinonide, which is the 21-acetate ester of fluocinolone acetonide and has the chemical name pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)],(6α,11β,16α)-.
LIDEX-E Cream is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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NEWS HIGHLIGHTS
Published Studies Related to Lidex-E (Fluocinonide Topical)
Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis. [2011.02]
OBJECTIVE: To determine the effect a novel formulation of fluocinonide cream on skin barrier function in subjects with atopic dermatitis... CONCLUSION: The authors have shown that short-term treatment with a novel formulation of 0.1% fluocinonide led to significantly improved barrier function as measured by basal TEWL in subjects with active moderate to severe AD. These data suggest short-term treatment with AD with a super-potent corticosteroid improves skin barrier function.
Topical corticosteroids in association with miconazole and chlorhexidine in the long-term management of atrophic-erosive oral lichen planus: a placebo-controlled and comparative study between clobetasol and fluocinonide. [1999.01]
OBJECTIVE: To evaluate the efficacy of a combination of topical corticosteroids with topical antimycotic drugs in the therapy of atrophic-erosive forms of oral lichen planus (OLP)... CONCLUSIONS: Our results suggest that a very potent topical corticosteroid such as clobetasol may control OLP in most cases, with no significant adrenal suppression or adverse effects. Moreover, a concomitant antimycotic treatment with miconazole gel and chlorhexidine mouthwashes is a useful and safe prophylaxis against oropharyngeal candidiasis.
Once-daily tazarotene gel versus twice-daily fluocinonide cream in the treatment of plaque psoriasis. [1998.05]
BACKGROUND: A new class of topical receptor-selective acetylenic retinoids, the first of which is tazarotene, has been developed. OBJECTIVE: Our purpose was to compare the safety, efficacy, and duration of therapeutic effect of 12 weeks of once-daily tazarotene 0.1% and 0.05% gel with that of twice-daily fluocinonide 0.05% cream in the treatment of patients with plaque psoriasis... CONCLUSION: Tazarotene 0.1% and 0.05% gels were safe and effective in the treatment of mild-to-moderate plaque psoriasis.
Comparative study of calcipotriene (MC 903) ointment and fluocinonide ointment in the treatment of psoriasis. [1994.11]
BACKGROUND: The topical vitamin D analogue calcipotriene has been reported to be an effective treatment for patients with psoriasis. Comparative studies with topical steroids are informative in judging this new therapy. OBJECTIVE: The purpose of this study was to evaluate the efficacy and safety of calcipotriene ointment 0.005% versus fluocinonide ointment 0.05% in the treatment of plaque psoriasis... CONCLUSION: Calcipotriene was superior to fluocinonide in the treatment of plaque psoriasis.
Double-blind clinical trial of 0.05% clobetasol propionate (corrected from proprionate) ointment in orabase and 0.05% fluocinonide ointment in orabase in the treatment of patients with oral vesiculoerosive diseases. [1994.06]
Because of their chronic nature treatment of oral vesiculoerosive diseases remains a challenge to the oral medicine specialist. Even though oral vesiculoerosive diseases respond well to systemic steroids, adverse side effects sometimes limit their use... Therefore normal carriers should be identified and treatment with antifungal therapy instituted before the patient begins using topical steroids.
Clinical Trials Related to Lidex-E (Fluocinonide Topical)
Fluocinonide Cream in Treating Symptoms of Vaginal Dryness and Painful Sexual Intercourse In Patients With Breast Cancer Undergoing Hormone Therapy [Recruiting]
This phase II trial studies how well giving fluocinonide cream works in treating symptoms of
vaginal dryness and painful sexual intercourse in patients with breast cancer undergoing
hormone therapy. Fluocinonide cream may prevent or lessen vaginal dryness and painful sexual
intercourse in patients undergoing hormone therapy.
Efficacy of Fluocinonide Cream 0.1% (Vanos(R)) in Reducing Itch in Subjects With Atopic Dermatitis [Recruiting]
The purpose of this study is to assess the efficacy and tolerability of short-term treatment
with fluocinonide cream 0. 1% (Vanos®) in the treatment of atopic dermatitis (AD). Our
hypothesis is that subjects will have a reduction in Investigator's Global Assessment scores
at Day 7 and Day 14 compared to Baseline.
Secondary objectives include the use of actigraphy monitoring to determine the ability of
Vanos® cream to reduce itch, and thus nocturnal scratching, in AD. Our hypothesis is that
subjects will have a reduction in nocturnal scratching activity, as measured by actigraphy
movement count per hour, at Day 7 and Day 14 compared to Baseline. Other secondary outcome
measures include Eczema Area and Severity Index (EASI) score, body surface area involvement,
Visual Analog Scale for itch, and Subject Global Assessment. The investigators hypothesize
that each of these measures will be improved at Day 7 and Day 14 compared to Baseline.
Medication adherence will be determined using objective adherence monitors. The
investigators also hypothesize that subjects will have improved adherence to a topical
medication for AD, compared to published sources, if they are only required to use the
medication for a short and defined duration.
Effectiveness of Imiquimod 3.75% Topical Cream Compared to Vanos Cream 0.1% in Subjects With Early Stage Cutaneous T-cell Lymphoma [Not yet recruiting]
This study is being conducted by the Department of Dermatology at the University of
Rochester. The purpose of this study is to determine safety, effectiveness, and tolerability
of two topical therapies, imiquimod and fluocinonide, for patients with early stage
Cutaneous T-cell Lymphoma (CTCL).
VANOS Cream and Skin Barrier Function [Recruiting]
The purpose of this study is to determine the effect of short-term therapy using "VANOS
Cream," a super-potent topical steroid cream on skin barrier function in patients with
atopic dermatitis. This cream is already approved for this indication, but the
investigators will further examine its effects on the skin barrier. This cream is a novel
formulation of fluocinonide designed to enhance compliance with a cream base, but have the
skin barrier repair properties of an ointment.
Using an Internet Study to Improve Adherence for Psoriasis Patients [Recruiting]
To evaluate whether participation in an Internet-based intervention helps improve short-term
and long-term psoriasis treatment outcomes, in particular, adherence.
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