NEWS HIGHLIGHTS
Published Studies Related to Lidocaine and Prilocaine (Lidocaine / Prilocaine Topical)
Local anesthetic effects of Lidocaine cream: randomized controlled trial using a standardized prick pain. [2011.07.31]
Abstract Background: ELA-max (4% Lidocaine) and EMLA cream (Lidocaine-Prilocaine 2.5%) are topicals used for superficial anesthesia. Only few studies have been published on their comparative effectiveness in close-to-practice pain models.
Management of pain associated with debridement of leg ulcers: a randomized, multicentre, pilot study comparing nitrous oxide-oxygen mixture inhalation and lidocaine-prilocaine cream. [2011.02]
BACKGROUND: Mechanical debridement of fibrin and/or necrosis promotes healing of arterial and venous leg ulcers but is limited by pain associated with the procedure. OBJECTIVE: The main objective of this study was to compare the respective analgesic effect of nitrous oxide oxygen mixture (NOOM) inhalation and lidocaine-prilocaine cream (LPC) application during the mechanical repeated debridement of chronic arterial and venous leg ulcers... CONCLUSION: This pilot study demonstrates the superiority of the LPC over NOOM for pain control during the mechanical debridement of chronic leg ulcers. (c) 2010 The Authors. Journal of the European Academy of Dermatology and Venereology (c) 2010 European Academy of Dermatology and Venereology.
Lidocaine/tetracaine medicated plaster: in minor dermatological and needle puncture procedures. [2010.11.12]
The lidocaine/tetracaine medicated plaster comprises a lidocaine/tetracaine 70 mg/70 mg patch and a controlled heat-assisted drug delivery pod that increases the diffusion of lidocaine and tetracaine into the dermis. Following a 1-hour application period, systemic absorption of lidocaine or tetracaine from the plaster was minimal...
The Effects of Combination Perianal-Intrarectal Lidocaine-Prilocaine Cream and Periprostatic Nerve Block for Pain Control during Transrectal Ultrasound Guided Biopsy of the Prostate: A Randomized, Controlled Trial. [2010.07]
PURPOSE: Prostate biopsy for diagnosing cancer can be painful. The efficacy and safety of combination perianal-intrarectal lidocaine-prilocaine (PILP) cream and periprostatic nerve block were compared with nerve block alone during transrectal ultrasound guided prostate biopsy (TRUS-Bx)... CONCLUSIONS: A combination of PILP cream and periprostatic nerve block reduced pain compared to the periprostatic nerve block alone. This safe, simple technique can be considered prior to TRUS-Bx to reduce patient discomfort.
Lidocaine spray administration during transrectal ultrasound guided prostate biopsy modified the discomfort and pain of the procedure: results of a randomized clinical trial. [2010.06]
OBJECTIVES: We report the results of a study about the possible benefit of lidocaine spray perineal administration before transrectal ultrasound guided biopsy of the prostate. Many patients frequently report some kind of discomfort and (or) pain during this procedure, that when pain is severe, may be necessary to interrupt... CONCLUSIONS: Pain score results showed that the use of intrarectal lidocaine spray provided significantly better pain control than cream and anaesthetic gel. Our pain score data suggests that lidocaine spray provides efficient patient comfort during prostate biopsy by reducing pain both during probe insertion and insertion of the needle through the prostate gland. The use of lidocaine spray makes an excellent alternative, causing a reduction of anal sphincter tone with better patient compliance and tolerability to the ultrasound probe during biopsies with an optimization in terms of cost-effectiveness of the procedure.
Clinical Trials Related to Lidocaine and Prilocaine (Lidocaine / Prilocaine Topical)
Tumescent Lidocaine Maximum Safe mg/kg Dosage [Enrolling by invitation]
This pharmacokinetic clinical trial is a dose ranging study of lidocaine in tumescent local
anesthesia. The goal is to understand the absorption pharmacokinetic of tumescent lidocaine
and to determine an objective (statistical) estimate of the maximum safe mg/kg dosage of
lidocaine in tumescent local anesthesia without liposuction.
Lidocaine Infusion for Chronic Pain in Opioid Dependent Patients [Recruiting]
Prescription drug abuse represents a major healthcare problem, with treatment costs reaching
billions of dollars annually in the United States alone. Today opioids are commonly
prescribed for chronic non-cancer pain and are only partially effective for short-term pain
relief. Whereas opioids are initially part of the solution for pain, it eventually often
turns to be a problem in patient with chronic pain. Long-term treatment with opioids can be
complicated by development of tolerance, dependency, addiction, abnormal pain sensitivity,
hormonal changes, and immune modulation. Unfortunately, the chronic use of anti-inflammatory
drugs is associated with a marked increase in adverse effects.
The purpose of this study is to determine whether systemic administration of lidocaine
provides effective pain relief in opioid dependent chronic pain patients. Investigators
intend to demonstrate that lidocaine infusion can improve pain relief and physical function
in opioid dependent patients, thus improving compliance and patient satisfaction, which may
potentially help wean patients off narcotics. The long-term goal of this proposal is to
decrease opioid dependence in chronic pain patients by using lidocaine infusion.
Lidocaine: Effect of Lidocaine in Chronic Cough [Completed]
People cough in order to clear their airways. Most coughs are caused by viruses and settle
down by themselves, but some people develop persistent coughing which can be anywhere from 8
weeks to several years. This is called chronic cough. People with chronic cough find the
symptom distressing and it can have a major impact on their quality of life. Patients with
chronic cough often report a sensation at the back of their throat which makes them feel an
urge to cough. There is some evidence that Lidocaine (an anaesthetic used during medical
procedures) can suppress a person's cough when given to patients via a nebuliser (a machine
that turns liquid into a fine mist).
It is currently unknown whether using a local anaesthetic, such as Lidocaine, in the form of
a throat spray would successfully suppress a person's cough. A throat spray would be an
easier treatment option in chronic cough patients. Thus, the investigators research aims to
compare cough rates, severity and urge to cough scores between Lidocaine throat spray and
nebulised Lidocaine.
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving [Recruiting]
We propose that the systemic administration of lidocaine following the induction of
cue-induced craving, relative to saline plus cue-induced craving or lidocaine without
cue-induced craving, will block the reconsolidation of cue memories. This will lead to a
reduction in cue-induced craving upon repeated testing as well as subsequent cocaine use and
basal craving.
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft [Completed]
The aim of the present study is to compare the antiarrhythmic and myocardial protective
effect between lidocaine, dexmedetomidine, and their combined infusion in subjects
undergoing coronary artery bypass graft.
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