Lidopen (Lidocaine Hydrochloride) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

Drug Interactions:

Caution should be exercised in administration to patient with known or suspected digitalis toxicity accompanied by atrioventricular block. See CONTRAINDICATIONS.

Many potent anesthetic drugs, neuromuscular blocking agents and possible amide local anesthetics may serve as triggering agents for the fulminant hypermetabolic process termed malignant hyperthermia.

OVERDOSAGE

Reactions due to overdosage are generally systemic in nature and involve the central nervous system and the cardiovascular system. See ADVERSE REACTIONS.

Should convulsions or signs of respiratory depression and arrest develop, the patency of the airway and adequacy of ventilation must be assured immediately. See MANAGEMENT OF ADVERSE REACTIONS.

The approximate oral LD50 of lidocaine hydrochloride in mice is 520 mg/kg. Plasma levels in excess of 8 mcg/mL in humans have been associated with serious adverse effects.

Dialysis is of negligible value in the treatment of acute overdosage from lidocaine hydrochloride.

CONTRAINDICATIONS

Lidocaine hydrochloride is contraindicated in patients with known hypersensitivity to local anesthetics of the amide type, in patients with STOKES-ADAMS Syndrome, Wolff-Parkinson-White Syndrome, or severe degrees of sinoatrial, atrio-ventricular, or intraventricular block.