WARNINGS
Lindane Shampoo should only be used in patients who cannot tolerate or have failed first-line treatment with safer medications for the treatment of lice. (See INDICATIONS AND USAGE.)
Neurologic Toxicity
Seizures and deaths have been reported following Lindane Shampoo use with repeat or prolonged application, but also in rare cases following a single application according to directions. Lindane Shampoo should be used with caution in infants, children, the elderly, and individuals with other skin conditions, and those who weigh < 110 lbs (50 kg) as they may be at risk of serious neurotoxicity.
Contraindications
Lindane Shampoo is contraindicated in premature infants and individuals with known uncontrolled seizure disorders.
Proper Use
Instruct patients on proper use of Lindane Shampoo, the amount to apply, how long to leave it on, and avoiding retreatment. Inform patients that itching occurs after the successful killing of lice and is not necessarily an indication for retreatment with Lindane Shampoo. (See DOSAGE AND ADMINISTRATION.)
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LINDANE SUMMARY
WARNINGS
Lindane Shampoo, USP 1%, is an ectoparasiticide and ovicide effective against Pediculus humanus capitis (head lice), Pthirus pubis (crab lice), and their ova. In addition to the active ingredient, lindane, it contains triethanolamine lauryl sulfate, polysorbate 60, hydrochloric acid, acetone and purified water to form a shampoo base. The pH may be adjusted with 10% hydrochloric acid solution and/or 10% sodium hydroxide solution.
Lindane Shampoo is indicated for the treatment of head lice (infestations of Pediculus humanus capitis), crab lice (infestations of Pthirus pubis), and their ova only in patients who
- cannot tolerate other approved therapies, or
- have failed treatment with other approved therapies.
Lindane Shampoo should be used in the context of an overall lice management program that includes:
- Visual inspection to ensure that the patient is currently infested with live lice (empty egg casings or "nits" can remain on hair shaft long after true infestation).
- Manual removal of nits using a comb designed for this purpose and/or individual removal with tweezers followed by close examination of the hair and scalp.
- Evaluation and treatment of sexual contacts simultaneously. Sexual contacts should be prescribed Lindane Shampoo only if they either have failed to respond to adequate doses of other approved therapies or are intolerant of other approved therapies.
- All recently worn clothing, underwear, pajamas, used sheets, pillowcases, and towels should be washed in very hot water or dry-cleaned.
Caregivers applying this product to patients should wear gloves less permeable to Lindane such as nitrile, latex with neoprene or sheer vinyl, and thoroughly clean hands after application. Natural latex gloves should be avoided because they are more permeable to Lindane.
Lindane Shampoo does not prevent infestation or reinfestation and should not be used to ward off a possible infestation.
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NEWS HIGHLIGHTSMedia Articles Related to Lindane (Lindane Topical)
Scabies
Source: MedicineNet PCR (Polymerase Chain Reaction) Specialty [2017.04.27]
Title: Scabies
Category: Diseases and Conditions
Created: 12/4/1999 12:00:00 AM
Last Editorial Review: 4/27/2017 12:00:00 AM
Published Studies Related to Lindane (Lindane Topical)
Comparison of the efficacy of topical 1% lindane vs 5% permethrin in scabies: a randomized, double-blind study. [2006.01]
BACKGROUND: Permethrin, a pyrethroid insecticide, is not yet available in Iran and may be a useful substitute for the control of scabies in Iran. AIM: To compare the efficacy of topical lindane with topical permethrin in the treatment of scabies in a population in Iran... CONCLUSION: Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study, and it seems that it could be an alternative treatment.
Oral ivermectin in scabies patients: a comparison with 1% topical lindane lotion. [2001.09]
Scabies. which constitutes a significant proportion of the outpatient attendance in tropical dermatology clinics, has so far been treated with lindane, crotamiton, sulphur, permethrin, etc...
Equivalent therapeutic efficacy and safety of ivermectin and lindane in the treatment of human scabies. [1999.06]
OBJECTIVE: To compare the therapeutic efficacy and safety of ivermectin and lindane for the treatment of human scabies... CONCLUSIONS: Ivermectin is as effective as lindane for the treatment of scabies. Ivermectin is simpler to use and, therefore, is a promising tool to improve compliance and to control infestations.
Comparative study of 5% permethrin cream and 1% lindane lotion for the treatment of scabies. [1990.02]
A multicenter, randomized, investigator-blind controlled trial was conducted to compare the safety and efficacy of a single, whole-body application of 5% permethrin cream with that of 1% lindane lotion for the treatment of scabies in 467 patients.Because of a lower potential for neurologic toxicity, permethrin may be preferable to lindane for the treatment of scabies particularly in children.
Treatment of pediculosis pubis. Clinical comparison of efficacy and tolerance of 1% lindane shampoo vs 1% permethrin creme rinse. [1987.10]
Pediculosis pubis (PP) is a common sexually transmitted disease. Current therapy with 1% lindane or various synergized pyrethrins as a single dose has been accepted as adequate by the medical community... On the basis of the high failure rate, we propose that the therapy of PP with any agent should include a second treatment at ten days.
Clinical Trials Related to Lindane (Lindane Topical)
Veron Scabies Education and Eradication Program [Completed]
The purpose of this project is to develop a community scabies eradication and education
program for the highly endemic areas surrounding the Veron community on the eastern tip of
the Dominican Republic. It proposes the use of oral Ivermectin as a replacement for topical
Lindane--a readily available medical formulation, pesticide, and environmental toxin that is
reported to be banned in the Dominican Republic as well as over 80 other countries
throughout the world.
Pediatric Head Lice Study Product Comparison [Completed]
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Page last updated: 2017-04-27
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