overdosage
Symptoms following acute NSAID overdose are usually limited to
lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally
reversible with supportive care. Gastrointestinal bleeding can occur and coma
has occurred following massive ibuprofen or mefenamic-acid overdose.
Hypertension, acute renal failure, and respiratory depression may occur but are
rare. Anaphylactoid reactions have been reported with therapeutic ingestion of
NSAIDs, and may occur following overdose.
Patients should be managed by symptomatic and supportive care following an
NSAID overdose. There are no specific antidotes. Emesis and/or activated
charcoal (60 to 100 in adults, 1 to 2 g/kg in children) and/or osmotic cathartic
may be indicated in patients seen within 4 hours of ingestion with symptoms or
following a large overdose (5 to 10 times the usual dose). Forced diuresis,
alkalinization of the urine, hemodialysis, or hemoperfusion would probably not
be useful due to etodolac’s high protein binding.
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CONTRAINDICATIONS
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Etodolac capsules are contraindicated in patients with known
hypersensitivity to etodolac.
Etodolac capsules should not be given to patients who have experienced
asthma, urticaria, or other allergic-type reactions after taking aspirin or
other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have
been reported in such patients (see WARNINGS, Anaphylactoid Reactions and PRECAUTIONS, Preexisting Asthma).
Etodolac capsules are contraindicated for the treatment of peri-operative
pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
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