Lyrica (Pregabalin) - Summary

LYRICA SUMMARY

Pregabalin is a drug with anti-seizure and anti-nociceptive properties.

LYRICA is indicated for:

• Management of neuropathic pain associated with diabetic peripheral neuropathy
• Management of postherpetic neuralgia
• Adjunctive therapy for adult patients with partial onset seizures
• Management of fibromyalgia
• Management of neuropathic pain associated with spinal cord injury

NEWS HIGHLIGHTS

Published Studies Related to Lyrica (Pregabalin)

The efficacy of pregabalin for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled double-blind study. [2015]
DESIGN: Prospective, randomized, placebo controlled, double blinded study... CONCLUSION: Pretreatment with pregabalin 150 mg prevents CRBD and also decreases

Pre-emptive analgesia with pregabalin and celecoxib decreases postsurgical pain following maxillomandibular advancement surgery: a randomized controlled clinical trial. [2014]
obstructive sleep apnea... CONCLUSION: Within the limitations of this study, a 1-time preoperative oral dose

Evaluation of the efficacy and safety of pregabalin, venlafaxine, and carbamazepine in patients with painful diabetic peripheral neuropathy. A randomized, double-blind trial. [2014]
venlafaxine in patients with painful diabetic neuropathy (PDN)... CONCLUSION: This study showed the efficacy of venlafaxine, pregabalin, and

Adjunctive use of controlled-release pregabalin in adults with treatment-resistant partial seizures: a double-blind, randomized, placebo-controlled trial. [2014]
OBJECTIVES: To assess the efficacy and tolerability of add-on pregabalin controlled-release formulation (PGB-CR) (doses of 165 or 330 mg/day) in patients with partial-onset seizures (POS). METHODS: This was a randomized, double-blind (DB), parallel-group study of PGB-CR once-daily as adjunctive treatment in adults with treatment-resistant partial seizures...

Comparison of pregabalin with pramipexole for restless legs syndrome. [2014]
alternative... CONCLUSIONS: Pregabalin provided significantly improved treatment outcomes as

more studies >>

Clinical Trials Related to Lyrica (Pregabalin)

A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy [Completed]
This study is designed to examine how pregabalin affects parameters of autonomic nerve regulation in correlation with change in pain, anxiety, and depressive symptoms in patients with diabetic neuropathy.

Role of Pregabalin in Treatment of Post-Op Pain in Fracture Patients [Completed]
This is a randomized, prospective, double-blind pilot study designed to evaluate the potential effectiveness of pregabalin in post-operative pain management for patients who have sustained a fracture.

PharmacofMRI of Anxiolytic Medications (Pregabalin) [Completed]
The purpose of this study is to use functional magnetic resonance imaging (fMRI) in healthy controls to examine the acute effects of certain anxiolytic medications on brain function. In this case, the medication pregabalin will be used. The investigators hypothesize that pregabalin (at doses of 50 mg and 200 mg, versus placebo) will yield a reduction in amygdala and insula activity (in a dose-dependent fashion) during emotion processing using fMRI.

A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome [Recruiting]
This study is being done to see if Lyrica helps people with irritable bowel syndrome.

Safety And Efficacy Of Lyrica (Regulatory Post Marketing Commitment Plan) [Active, not recruiting]
The objective of this Investigation is to evaluate the safety and efficacy of Lyrica in medical practice. Also, occurrence of unknown and known adverse drug reactions (ADRs) in subjects treated with Lyrica will be monitored during the survey period, and whether an additional treatment outcome investigation and/or a post-marketing clinical study is required in the future will be determined.

more trials >>

Reports of Suspected Lyrica (Pregabalin) Side Effects

Pain (1561),  Drug Ineffective (952),  Dizziness (696),  Weight Increased (605),  Feeling Abnormal (562),  Somnolence (501),  Malaise (471),  Pain in Extremity (471),  Oedema Peripheral (440),  Insomnia (373), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Lyrica review by 46 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Fibromyalgia
Dosage & duration:		150mg taken 2x per day for the period of Still taking it
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		Lyrica has made a huge difference with my fibromyalgia pain. I have had fibromyalgia for 13 plus years and was excited about the FDA finally approving Lyrica for fibromyalgia patients. I would recomend that anyone suffering from fibromyalgia try this medication, along with a healthy diet and exercise. Lyrica is not a cure, but I have improved probably 75% over this last year.
Side effects:		It took my body 3-4 weeks to get used to Lyrica. It did make me feel a little different "high" would probably be the best way to describe it. I have since adjusted and have had no further side effects.
Comments:		Started with 50 mg 2x a day (morning and afternoon), then gradually built up to 150mg 2x a day.

Lyrica review by 63 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		fibromylgia
Dosage & duration:		5 0mg. taken 2 to 3 times day for the period of app. 4 yrs.
Other conditions:		arthritis- asteproesis
Other drugs taken:		zanaz- lorotab- pristiq
		Reported Results
Benefits:		the benefits foe the pain was good, it helped the constant pain i was having in my muscles and the over all aching
Side effects:		sleepiness- fatigu memory loss- confusion-depression- trouble breathigng
Comments:		good relief from pain . i take 100mg. at bed time it helps me sleep well but am tired in the am. it makes me just want to lie on couch and sleep all day this makes my arthritis worse. am tired and draggy all day with no desire to do any thing, even the thing that have always interested me.am prescribed one 50g for daytimebut cannot tolerate it because i will sleep all day and be very light headed and unable to concentrate.

Lyrica review by 58 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		neuropathic pain aand fibromyalgia
Dosage & duration:		300mg/day taken 150mg twice/day for the period of 2 months
Other conditions:		severe spasms, severe osteoarthritis, migraines
Other drugs taken:		Klonopin, Ultram
		Reported Results
Benefits:		None
Side effects:		Extreme swelling of face, hands and feet, as well as, raised welts on skin
Comments:		Patient was being weened off of 3600mg/day of Neurontin on to Lyrica. As the dosage taken of Neurontin lessened and that of Lyrica increased so did the side effects. Patient was taken totally off of Lyrica and, successfully, placed back on Neurontin.