Metaproterenol (Metaproterenol Sulfate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse reactions are similar to those noted with other sympathomimetic agents.

The following table of adverse experiences is derived from 26 controlled clinical trials with 496 patients treated with metaproterenol sulfate tablets:

Metaproterenol Sulfate Tablets Incidence of Adverse Events Reported Among 496 Patients Treated in 26 Controlled Clinical Trials

ADVERSE EXPERIENCE	INCIDENCE
	Number of Patients	%
Cardiovascular
Chest Pain	1	0.2
Edema	1	0.2
Hypertension	2	0.4
Palpitations	19	3.8
Tachycardia	85	17.1
Central Nervous System
Dizziness	12	2.4
Drowsiness	3	0.6
Fatigue	7	1.4
Headache	35	7.0
Insomnia	9	1.8
Nervousness	100	20.2
Sensory disturbances	1	0.2
Syncope	2	0.4
Weakness	1	0.2
Dermatological
Diaphoresis	1	0.2
Hives	1	0.2
Pruritus	2	0.4
Gastrointestinal
Appetite changes	2	0.4
Diarrhea	6	1.2
Gastrointestinal distress	15	3.0
Nausea	18	3.6
Vomiting	4	0.8
Musculoskeletal
Pain	1	0.2
Spasms	1	0.2
Tremor	84	16.9
Ophthalmological
Blurred vision	1	0.2
Oro-Otolaryngeal
Dry mouth/throat	2	0.4
Laryngeal changes	1	0.2
Bad taste	4	0.8
Respiratory
Asthma exacerbation	10	2.0
Coughing	1	0.2
Other
Chatty	1	0.2
Chills	1	0.2
Clonus noted on flexing foot	1	0.2
Feverish	2	0.4
Flu Symptoms	1	0.2
Facial and finger puffiness	1	0.2