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Methenamine Hippurate (Methenamine Hippurate) - Summary

 
 



SUMMARY

Methenamine hippurate tablets, USP are available as 1 g oval shaped, scored and peach colored tablets.

Methenamine hippurate tablets, USP are indicated for prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug should only be used after eradication of the infection by other appropriate antimicrobial agents.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of methenamine hippurate tablets, USP and other antibacterial drugs, methenamine hippurate tablets, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.


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NEWS HIGHLIGHTS

Media Articles Related to Methenamine Hippurate (Methenamine)

Urinary Tract Infections in Children
Source: MedicineNet Bedwetting Specialty [2017.08.03]
Title: Urinary Tract Infections in Children
Category: Diseases and Conditions
Created: 2/1/2010 12:00:00 AM
Last Editorial Review: 8/3/2017 12:00:00 AM

Urinary Tract Infection Quiz
Source: MedicineNet Hydronephrosis Specialty [2017.07.20]
Title: Urinary Tract Infection Quiz
Category: MedicineNet Quiz
Created: 6/10/2010 12:00:00 AM
Last Editorial Review: 7/20/2017 7:26:55 PM

Urinary Tract Infections (UTIs)
Source: MedicineNet Bedwetting Specialty [2017.06.12]
Title: Urinary Tract Infections (UTIs)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 6/12/2017 12:00:00 AM

Urinary Tract Infection (UTI) Symptoms, Diagnosis, Medication
Source: MedicineNet trimethoprim Specialty [2016.08.01]
Title: Urinary Tract Infection (UTI) Symptoms, Diagnosis, Medication
Category: Slideshows
Created: 12/4/2008 12:00:00 AM
Last Editorial Review: 8/1/2016 12:00:00 AM

more news >>

Published Studies Related to Methenamine Hippurate (Methenamine)

Methenamine hippurate for preventing urinary tract infections. [2012]
CONCLUSIONS: Methenamine hippurate may be effective for preventing UTI

Methenamine hippurate for preventing urinary tract infections. [2007.10.17]
CONCLUSIONS: Methenamine hippurate may be effective for preventing UTI in patients without renal tract abnormalities, particularly when used for short-term prophylaxis. It does not appear to work in patients with neuropathic bladder or in patients who have renal tract abnormalities. The rate of adverse events was low, but poorly described.There is a need for further large well-conducted RCTs to clarify this question, particularly for longer term use for people without neuropathic bladder.

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Clinical Trials Related to Methenamine Hippurate (Methenamine)

Efficacy Study of Acriflavine Hydrochloride + Methenamine + Methylthioninium Chloride vs Placebo for the Rapid Relief of Symptoms Urinary Tract Infection [Not yet recruiting]
The purpose of this study is to evaluate the efficacy of the combination of Acriflavine hydrochloride + Methenamine + Methylthioninium chloride produced by EMS S/A, using the comparator Placebo, the rapid relief of symptoms in uncomplicated lower urinary tract infection in women.

Patients Response to Early Switch To Oral:Osteomyelitis Study [Not yet recruiting]
Based on the current literature, investigators hypothesize that patients with osteomyelitis who are treated with the standard approach of intravenous antibiotics for the full duration of therapy will have the same clinical outcomes as patients treated with the experimental approach of intravenous antibiotics with early switch to oral antibiotics. The primary objective of this study is to compare patients with osteomyelitis treated with the standard approach of intravenous antibiotics for the full duration of therapy versus patients treated with intravenous antibiotics with an early switch to oral antibiotics in relation to clinical outcomes at 12 months after discontinuation of antibiotic therapy. Secondary objectives of the study include the evaluation of adverse events related to the use of antibiotics as well as the cost of care evaluated from the hospital perspective.

The Association Between the Transfer of Lactobacilli From the Gastrointestinal Tract to the Vagina and the Prevention / Eradication of Abnormal Vaginal Flora in High Risk Pregnancies [Not yet recruiting]
Pregnant women at high risk for preterm labor from at least 13 weeks of gestation will be

tested to detect abnormal vaginal flora (AVF) or its severe form - bacterial vaginosis (BV)

by taking vaginal smear. Treatment will be given according to the results.

Probiotics in Girls With Spina Bifida [Withdrawn]
Girls with spina bifida also have bladder problems. This is because they need temporary placement of a tube into the bladder to remove urine. This thin flexible tube is called a catheter. It can increase the risk of having bacteria in the urine. This in turn can lead to urinary tract infection (UTI). Some girls with spina bifida are given antibiotics. These are medicines used to treat infections caused by bacteria. The medicine is used to prevent UTI. However, long-term treatment with these medicines can have side effects. For example, the bacteria may become resistant to the antibiotics. Also, bacteria in the urine can persist. UTI can still occur in patients on antibiotics. UTI in girls occurs because bacteria migrate from the rectum to the vagina area. This gives the bacteria access to the bladder. Also, in girls with spina bifida, the access to the bladder is easier because of the catheter. Probiotics are friendly bacteria. They are available as dietary supplements and as food. They contain helpful bacteria. Yogurt is an example of a food that contains probiotics. The purpose of this study is to find out, if probiotics taken for 6 months can prevent UTI in girls with spina bifida. We will also try to find out whether changes in urine bacteria are associated with the taking of the probiotics. A vaginal and rectal swab will also be done to find out if taking probiotics has any benefits on preventing bacteria.

Probiotics as a Prophylactic Aid in Women With Recurrent Urinary Tract Infections (UTI's) [Recruiting]
To investigate if administration of probiotics, either orally or vaginally,

- Can reduce the number of episodes of acute bacterial cystitis and/or

- Has tolerable adverse effect profile

- Improves general QoL in these women

- Improves the immune function and other physiological stress markers

- Reduces inflammation in urinary bladder epithelium

more trials >>


Page last updated: 2017-08-03

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