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Methyltestosterone (Methyltestosterone) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

  1. Anticoagulants:   C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. Patients receiving oral anticoagulant therapy require close monitoring, especially when androgens are started or stopped.
  2. Oxyphenbutazone:   Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
  3. Insulin:   In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements.

OVERDOSAGE

There have been no reports of acute overdosage with the androgens.

CONTRAINDICATIONS

Androgens are contraindicated in men with carcinomas of the breast or with known or suspected carcinomas of the prostate, and in women who are or may become pregnant. When administered to pregnant women, androgens cause virilization of the external genitalia of the female fetus. This virilization includes clitoromegaly, abnormal vaginal development, and fusion of genital folds to form a scrotal-like structure. The degree of masculinization is related to the amount of drug given and the age of the fetus, and is most likely to occur in the female fetus when the drugs are given in the first trimester. If the patient becomes pregnant while taking these drugs, she should be apprised of the potential hazard to the fetus.

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