DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Metoclopramide (Metoclopramide Hydrochloride) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

In general, the incidence of adverse reactions correlates with the dose and duration of metoclopramide administration. The following reactions have been reported, although in most instances, data do not permit an estimate of frequency.

CNS Effects:

Restlessness, drowsiness, fatigue, and lassitude occur in approximately 10% of patients receiving the most commonly prescribed dosage of 10 mg q.i.d. (see PRECAUTIONS). Insomnia, headache, confusion, dizziness, or mental depression with suicidal ideation (see  WARNINGS) occur less frequently. The incidence of drowsiness is greater at higher doses. There are isolated reports of convulsive seizures without clearcut relationships to metoclopramide. Rarely, hallucinations have been reported.

Extrapyramidal Reactions (EPS):

Acute dystonic reactions, the most common type of EPS associated with metoclopramide, occur in approximately 0.2% of patients (1 in 500) treated with 30 to 40 mg of metoclopramide per day. Symptoms include involuntary movements of limbs, facial grimacing, torticollis, oculogyric crisis, rhythmic protrusion of tongue, bulbar type of speech, trismus, opisthotonus (tetanus-like reactions), and, rarely, stridor and dyspnea possibly due to laryngospasm; ordinarily these symptoms are readily reversed by diphenhydramine (see WARNINGS).

Parkinsonian-like symptoms may include bradykinesia, tremor, cogwheel rigidity, mask-like facies (see WARNINGS).

Tardive dyskinesia most frequently is characterized by involuntary movements of the tongue, face, mouth, or jaw, and sometimes by involuntary movements of the trunk and/or extremities; movements may be choreoathetotic in appearance (see WARNINGS).

Motor restlessness (akathisia) may consist of feelings of anxiety, agitation, jitteriness, and insomnia, as well as inability to sit still, pacing, foot-tapping. These symptoms may disappear spontaneously or respond to a reduction in dosage.

Neuroleptic Malignant Syndrome: Rare occurrences of neuroleptic malignant syndrome (NMS) have been reported. This potentially fatal syndrome is comprised of the symptom complex of hyperthermia, altered consciousness, muscular rigidity, and autonomic dysfunction (see WARNINGS).

Endocrine Disturbances : Galactorrhea, amenorrhea, gynecomastia, impotence secondary to hyperprolactinemia (see PRECAUTIONS). Fluid retention secondary to transient elevation of aldosterone (see CLINICAL PHARMACOLOGY).

Cardiovascular: Hypotension, hypertension, supraventricular tachycardia, bradycardia, fluid retention, acute congestive heart failure and possible AV block (see CONTRAINDICATIONS and PRECAUTIONS).

Gastrointestinal: Nausea and bowel disturbances, primarily diarrhea.

Hepatic: Rarely, cases of hepatotoxicity, characterized by such findings as jaundice and altered liver function tests, when metoclopramide was administered with other drugs with known hepatotoxic potential.

Renal: Urinary frequency and incontinence.

Hematologic: A few cases of neutropenia, leukopenia, or agranulocytosis, generally without clearcut relationships to metoclopramide. Methemoglobinemia, in adults and especially with overdosage in neonates (see OVERDOSAGE). Sulfhemoglobinemia in adults.

Allergic Reactions: A few cases of rash, urticaria, or bronchospasm, especially in patients with a history of asthma. Rarely, angioneurotic edema, including glossal or laryngeal edema.

Miscellaneous: Visual disturbances. Porphyria.



REPORTS OF SUSPECTED METOCLOPRAMIDE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Metoclopramide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Metoclopramide side effects / adverse reactions in 88 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-03

Patient: 88 year old female

Reactions: Face Oedema

Suspect drug(s):
Morphine Sulfate
    Indication: Product Used FOR Unknown Indication

Vancomycin
    Indication: Product Used FOR Unknown Indication

Metoclopramide
    Indication: Product Used FOR Unknown Indication

Metronidazole IN Plastic Container
    Indication: Product Used FOR Unknown Indication

Ciprofloxacin IN Dextrose
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Amitriptyline HCL; Lidocaine; Trospium Chloride; Cetirizine HCL; Polyethylene Glycol; Simvastatin; Propylthiouracil



Possible Metoclopramide side effects / adverse reactions in 88 year old female

Reported by a health professional (non-physician/pharmacist) from Denmark on 2011-10-03

Patient: 88 year old female

Reactions: Face Oedema

Suspect drug(s):
Kadian
    Dosage: sc
    Indication: Product Used FOR Unknown Indication

Vancomycin
    Dosage: iv
    Indication: Product Used FOR Unknown Indication

Metoclopramide
    Dosage: sc
    Indication: Product Used FOR Unknown Indication

Metronidazole
    Dosage: iv
    Indication: Product Used FOR Unknown Indication

Ciprofloxacin
    Dosage: iv
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Trospium Chloride; Polyethylene Glycol; Simvastatin; Cetirizine HCL; Amitriptyline HCL; Lidocaine; Propylthiouracil



Possible Metoclopramide side effects / adverse reactions in 88 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-04

Patient: 88 year old female

Reactions: Face Oedema

Suspect drug(s):
Metoclopramide
    Dosage: subcutaneous
    Indication: Product Used FOR Unknown Indication

Metronidazole
    Dosage: ntravenous drip
    Indication: Product Used FOR Unknown Indication

Morphine Sulfate
    Dosage: subcutaneous
    Indication: Product Used FOR Unknown Indication

Vancomycin Hychloride
    Dosage: intravenous drip
    Indication: Product Used FOR Unknown Indication

Ciprofloxacin
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Amitriptyline HCL; Polyethylene Glycol; Propylthiouracil; Lidocaine; Trospium Chloride; Cetirizine HCL; Simvastatin



See index of all Metoclopramide side effect reports >>

Drug label data at the top of this Page last updated: 2012-01-18

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017