WARNING: FETAL TOXICITY
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When pregnancy is detected, discontinue
MICARDIS as soon as possible [see Warnings and Precautions ]
.
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Drugs that act directly on the renin-angiotensin
system can cause injury and death to the developing fetus [see Warnings and Precautions ].
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MICARDIS SUMMARY
MICARDIS is a non-peptide angiotensin II
receptor (type AT1) antagonist.
Hypertension
MICARDIS is indicated for the treatment of
hypertension, to lower blood pressure. Lowering blood pressure reduces
the risk of fatal and nonfatal cardiovascular events, primarily strokes
and myocardial infarctions. These benefits have been seen in controlled
trials of antihypertensive drugs from a wide variety of pharmacologic
classes including the class to which this drug principally belongs.
Control of high blood pressure should be
part of comprehensive cardiovascular risk management, including, as
appropriate, lipid control, diabetes management, antithrombotic therapy,
smoking cessation, exercise, and limited sodium intake. Many patients
will require more than one drug to achieve blood pressure goals. For
specific advice on goals and management, see published guidelines,
such as those of the National High Blood Pressure Education ProgramÂ’s
Joint National Committee on Prevention, Detection, Evaluation, and
Treatment of High Blood Pressure (JNC).
Numerous antihypertensive drugs, from a variety of
pharmacologic classes and with different mechanisms of action, have
been shown in randomized controlled trials to reduce cardiovascular
morbidity and mortality, and it can be concluded that it is blood
pressure reduction, and not some other pharmacologic property of the
drugs, that is largely responsible for those benefits. The largest
and most consistent cardiovascular outcome benefit has been a reduction
in the risk of stroke, but reductions in myocardial infarction and
cardiovascular mortality also have been seen regularly.
Elevated systolic or diastolic pressure
causes increased cardiovascular risk, and the absolute risk increase
per mmHg is greater at higher blood pressures, so that even modest
reductions of severe hypertension can provide substantial benefit.
Relative risk reduction from blood pressure reduction is similar across
populations with varying absolute risk, so the absolute benefit is
greater in patients who are at higher risk independent of their hypertension
(for example, patients with diabetes or hyperlipidemia), and such
patients would be expected to benefit from more aggressive treatment
to a lower blood pressure goal.
Some antihypertensive drugs have smaller blood pressure effects (as
monotherapy) in black patients, and many antihypertensive drugs have
additional approved indications and effects (e.g., on angina, heart
failure, or diabetic kidney disease). These considerations may guide
selection of therapy.
It may
be used alone or in combination with other antihypertensive agents
[see Clinical Studies ]
.
CardiovascularRisk Reduction
MICARDIS
is indicated for reduction of the risk of myocardial infarction, stroke,
or death from cardiovascular causes in patients 55 years of age or
older at high risk of developing major cardiovascular events who are
unable to take ACE inhibitors.
High risk for cardiovascular events can be evidenced by a history
of coronary artery disease, peripheral arterial disease, stroke, transient
ischemic attack, or high-risk diabetes (insulin-dependent or non-insulin
dependent) with evidence of end-organ damage
[see
Clinical Studies ]
. Â MICARDIS can be used in addition to other needed treatment
(such as antihypertensive, antiplatelet or lipid-lowering therapy)
[see Clinical Studies ]
.
Studies
of telmisartan in this setting do not exclude the possibility that
telmisartan may not preserve a meaningful fraction of the effect of
the ACE inhibitor to which it was compared. Consider using the ACE
inhibitor first, and, if it is stopped for cough only, consider re-trying
the ACE inhibitor after the cough resolves.
Use of telmisartan with an ACE inhibitor is not recommended
[see Warnings and Precautions ]
.
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NEWS HIGHLIGHTSMedia Articles Related to Micardis (Telmisartan)
High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes Source: MedicineNet Facial Nerve Problems Specialty [2017.09.19] Title: High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes Category: MedicineNet Quiz Created: 2/9/2011 12:00:00 AM Last Editorial Review: 9/19/2017 6:02:11 PM
Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy) Source: MedicineNet Congenital Heart Disease Specialty [2017.07.26] Title: Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy) Category: Diseases and Conditions Created: 12/31/1997 12:00:00 AM Last Editorial Review: 7/26/2017 12:00:00 AM
High Blood Pressure (Hypertension) Source: MedicineNet Polycystic Ovary Specialty [2017.03.31] Title: High Blood Pressure (Hypertension) Category: Symptoms and Signs Created: 1/15/2014 12:00:00 AM Last Editorial Review: 3/31/2017 12:00:00 AM
Portal Hypertension Source: MedicineNet nitroglycerin Specialty [2016.09.06] Title: Portal Hypertension Category: Diseases and Conditions Created: 1/31/2005 12:00:00 AM Last Editorial Review: 9/6/2016 12:00:00 AM
Picture of Hypertension Source: MedicineNet betaxolol ophthalmic Specialty [2014.12.09] Title: Picture of Hypertension Category: Images Created: 2/3/2011 12:00:00 AM Last Editorial Review: 12/9/2014 12:00:00 AM
Published Studies Related to Micardis (Telmisartan)
TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study
protocol for a randomized controlled trial. [2015] BACKGROUND: Experimental studies suggest that angiotensin II plays a central role
in the pathogenesis of abdominal aortic aneurysm... TEDY will examine the potential of a
promising treatment strategy for patients with small abdominal aortic aneurysms.
A meta-analysis of randomized trials of telmisartan versus active controls for
insulin resistance in hypertensive patients. [2014] To determine whether telmisartan improves insulin resistance compared with other
antihypertensive drugs, we performed a meta-analysis of randomized controlled
trials (RCTs) of telmisartan. MEDLINE, EMBASE, and the Cochrane Central Register
of Controlled Trials were searched through December 2013...
Effects of telmisartan and losartan on cardiovascular protection in Japanese hypertensive patients. [2011.11] The Telmisartan and Losartan Cardiac Evaluation Trial, a multicenter, prospective, randomized, open-labeled, blinded-endpoint trial, was designed to compare the effects of two angiotensin II receptor blockers (ARBs), telmisartan and losartan, on cardiovascular protection in Japanese patients with mild to moderate essential hypertension...
High-dose treatment with telmisartan induces monocytic peroxisome proliferator-activated receptor-gamma target genes in patients with the metabolic syndrome. [2011.10] The present study aimed to explore the anti-inflammatory effects and peroxisome proliferator-activated receptor-gamma (PPARgamma)-activating properties of the angiotensin type 1 receptor blocker telmisartan by analysis of serum interleukin 6 levels and monocytic PPARgamma target gene expression in drug-naive patients with the metabolic syndrome...
Cardiovascular and renal outcomes with telmisartan, ramipril, or both in people at high renal risk: results from the ONTARGET and TRANSCEND studies. [2011.03.15] CONCLUSIONS: This post hoc analysis does not support dual therapy over monotherapy in high-vascular risk patients with low glomerular filtration rate or albuminuria. This observation is a post hoc comparison and should be interpreted appropriately. CLINICAL TRIAL REGISTRATION: URL: http://clinicaltrials.gov Identifier: NCT00153101.
Clinical Trials Related to Micardis (Telmisartan)
CKD-828 Drug Interaction Study (Telmisartan) [Completed]
The purpose of this study is to evaluate the Pharmacokinetic drug interaction and safety of
Telmisartan between free combination of Telmisartan and S-amlodipine and Telmisartan
monotherapy.
Bioequivalence of BIBR 277 Tablet Compared With Capsule in Healthy Male Volunteers [Completed]
A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® / LORZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM) [Completed]
The primary aim of the trial is to compare the influence of MICARDIS® (telmisartan) and
COZAAR® / LORZAAR® (losartan) in lowering ambulatory diastolic blood pressure (DBP) during
the last 6 hours of the 24-hour dosing interval as measured by ABPM. Secondary objectives
include evaluations of: 1) change from baseline in mean systolic blood pressure (SBP) during
the last 6 hours of the 24-hour dosing interval as measured by ABPM, 2) changes from
baseline in SBP and DBP during other periods during the 24-hour ABPM profile, 3) changes
from baseline in mean seated trough SBP and DBP as measured by manual cuff sphygmomanometer,
and 4) responder rates based on both ABPM and trough cuff blood pressure
CKD-828 (80/5mg) Pharmacokinetic Study [Completed]
A randomized, open-label, single-dose, two-period, two-way, crossover study to compare the
pharmacokinetics and safety CKD-828 (Fixed Dose Combination Tablet) to coadministration
telmisartan and s-amlodipine in health volunteers.
Reports of Suspected Micardis (Telmisartan) Side Effects
Dizziness (27),
Interstitial Lung Disease (23),
Blood Pressure Increased (17),
Renal Impairment (17),
Hypertension (17),
Drug Ineffective (14),
Malaise (13),
Nausea (13),
Headache (12),
Dyspepsia (12), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 4 ratings/reviews, Micardis has an overall score of 5. The effectiveness score is 7 and the side effect score is 6.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| Micardis review by 55 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Considerably Effective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | hypertension |
Dosage & duration: | | 40 mg taken daily for the period of ongoing, for six months |
Other conditions: | | diabetes type 2, depression/anxiety |
Other drugs taken: | | metformin hydrochloride, venlafaxine hydrochloride | | Reported Results |
Benefits: | | reduced blood pressure to within acceptable limits. replaced previous drug (ACE inhibitor) with undesirable side effects. |
Side effects: | | none noticed |
Comments: | | one tablet daily, in the morning. |
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| Micardis review by 51 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Considerably Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | high blood pressure |
Dosage & duration: | | 80mg a day taken 5 months for the period of 5 months |
Other conditions: | | None |
Other drugs taken: | | None | | Reported Results |
Benefits: | | Reduced blood pressure. Since takink telmisartan my blood pressure levels went down to normal. I could do my regular activities, including sports. |
Side effects: | | Reduced sex drive, erectile disfunction. Constant respiratory infection. Since taking telmisartan i have been constantly with intense colds and respiratory tract infections. Plus my sexual drive has reduced considerably. I am not interested in sex and when I had to have sexual relations i experienced difficulty maintaining an erection. |
Comments: | | Only medication was prescribed. temisartan 80 mg a day. I have benn taking it for more than 5 months. |
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| Micardis review by 51 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Considerably Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | high blood pressure |
Dosage & duration: | | 80mg a day taken 5 months for the period of 5 months |
Other conditions: | | None |
Other drugs taken: | | None | | Reported Results |
Benefits: | | Reduced blood pressure. Since takink telmisartan my blood pressure levels went down to normal. I could do my regular activities, including sports. |
Side effects: | | Reduced sex drive, erectile disfunction. Constant respiratory infection. Since taking telmisartan i have been constantly with intense colds and respiratory tract infections. Plus my sexual drive has reduced considerably. I am not interested in sex and when I had to have sexual relations i experienced difficulty maintaining an erection. |
Comments: | | Only medication was prescribed. temisartan 80 mg a day. I have benn taking it for more than 5 months. |
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Page last updated: 2017-09-19
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