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Miochol-E (Acetylcholine Chloride) - Warnings and Precautions

 
 



WARNINGS

DO NOT GAS STERILIZE.   If blister or peelable backing is damaged or broken, sterility of the enclosed vial and ampoule cannot be assured. Open under aseptic conditions only.

PRECAUTIONS

G eneral

If miosis is to be obtained quickly with Miochol®-E (acetylcholine chloride intraocular solution), anatomical hindrances to miosis, such as anterior or posterior synechiae, must be released, prior to administration of Miochol-E. During cataract surgery, use Miochol-E only after delivery of the lens.

      Aqueous solutions of acetylcholine chloride are unstable. Prepare solution immediately before use. Do not use solution which is not clear and colorless. Discard any solution that has not been used.

D rug Interactions

Although clinical studies with acetylcholine chloride and animal studies with acetylcholine or carbachol revealed no interference, and there is no known pharmacological basis for an interaction, there have been reports that acetylcholine chloride and carbachol have been ineffective when used in patients treated with topical nonsteroidal anti-inflammatory agents.

P ediatric Use

Safety and effectiveness in pediatric patients have not been established.

Page last updated: 2007-05-08

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