NEWS HIGHLIGHTS
Published Studies Related to Mitosol (Mitomycin)
Effects of mitomycin-C on tear film, corneal biomechanics, and surface
irregularity in mild to moderate myopic surface ablation: preliminary results. [2014] DESIGN: Double-masked randomized clinical trial... CONCLUSION: Use of MMC in PRK did not appear to contribute significantly to
Inhibition of epidural fibrosis after microendoscopic discectomy with topical
application of mitomycin C: a randomized, controlled, double-blind trial. [2013] discectomy (MED)... CONCLUSIONS: Although no benefit was observed clinically, the authors observed a
Postoperative treatment with topical diclofenac versus topical dexamethasone
after combined phacotrabeculectomy with mitomycin C. [2013] (Voltaren Ophthalmic) after combined phacotrabeculectomy with mitomycin C... CONCLUSIONS: In this preliminary study, diclofenac sodium is at least as good as
Prevention of adhesion after endoscopic sinus surgery: role of mitomycin C. [2011] Adhesions after endoscopic sinus surgery (ESS) are a potential cause of surgical
failure... MMC may reduce adhesions after ESS, but further studies with different doses,
sample size and frequent use of topical MMC is recommended.
Mitomycin C and the endoscopic treatment of laryngotracheal stenosis: are two
applications better than one? [2009] clinical trial... CONCLUSIONS: This prospective randomized double-blind placebo-controlled trial
Clinical Trials Related to Mitosol (Mitomycin)
Intravesical Adjuvant Electromotive Mitomycin-C [Completed]
In laboratory and clinical studies, intravesical electromotive drug administration increased
mitomycin bladder uptake, improving clinical efficacy in high-risk non-muscle invasive
urothelial bladder cancer. The investigators' aim was to compare transurethral resection of
bladder tumor and adjuvant intravesical electromotive mitomycin with transurethral resection
and adjuvant intravesical passive diffusion mitomycin and transurethral resection alone in
patients with primary stage pTa-pT1 and grade G1-G2 urothelial bladder cancer Patients will
be randomly assigned to: transurethral resection alone, transurethral resection and
adjuvant intravesical 40 mg passive diffusion mitomycin dissolved in 50 ml sterile water
infused over 60 minutes once a week for 6 weeks, or transurethral resection and adjuvant
intravesical 40 mg electromotive mitomycin dissolved in 100 ml sterile water with 23 mA
pulsed electric current for 30 minutes once a week for 6 weeks. Patients in the intravesical
adjuvant electromotive and passive diffusion mitomycin groups who are disease-free 3 months
after induction treatment, will be scheduled to receive monthly intravesical instillation
for 10 months, with the same dose and methods of infusion as initial assigned treatment. All
patients will be assessed for safety. The investigators' primary endpoints are recurrence
rate and disease-free interval. Analyses will be done by intention to treat.
Topical Interferon Alfa 2b and Mitomycin C in Conjunctival-Corneal Intraepithelial Neoplasia [Active, not recruiting]
The purpose of this study is to evaluate the therapeutic efficacy of interferon alfa 2b and
topical mitomycin C in patients with diagnosis of conjunctival-corneal intraepithelial
neoplasia.
Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors [Active, not recruiting]
This phase I trial studies the side effects and best dose of veliparib when given with or
without mitomycin C in treating patients with solid tumors that have spread to other places
in the body, cannot be removed by surgery or have come back. Veliparib may stop the growth
of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in
chemotherapy, such as mitomycin C, work in different ways to stop the growth of tumor cells,
either by killing the cells, by stopping them from dividing, or by stopping them from
spreading. Giving veliparib together with mitomycin C may kill more tumor cells.
Study of Mitomycin C and Nasal Splint to Treat Nasal Synechiae [Completed]
This study evaluates whether Mitomycin C is an effective alternative to septal splints in
the treatment of nasal synechiae.
Ologen Collagen Matrix Safety and Effective Comparison With Mitomycin-C(MMC) in Glaucoma Surgery [Completed]
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