Motrin (Ibuprofen) - Summary

MOTRIN SUMMARY

MOTRIN® (ibuprofen) Suspension 100 mg/5 mL

The active ingredient in MOTRIN is ibuprofen, which is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. It is a white to off-white crystalline powder, with a melting point of 74° to 77°C. It is practically insoluble in water (<0.1 mg/mL), but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid.

In Children   MOTRIN is indicated:

• For reduction of fever in patients aged 6 months and older.
• For relief of mild to moderate pain in patients aged 6 months and older.
• For relief of signs and symptoms of juvenile arthritis.

In Adults   MOTRIN is indicated:

• For relief of mild to moderate pain.
• For treatment of primary dysmenorrhea.
• For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.

Since there have been no controlled trials to demonstrate whether there is any beneficial effect or harmful interaction with the use of ibuprofen in conjuction with aspirin, the combination cannot be recommended (see PRECAUTIONS -- Drug Interactions).

See all Motrin indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Motrin (Ibuprofen)

Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. [2015]
CONCLUSIONS: The combination of ibuprofen 400 mg plus codeine 25.6 mg to

Intramuscular ketorolac versus oral ibuprofen for pain relief in first-trimester surgical abortion: a randomized clinical trial. [2014]
ketorolac for pain management during first-trimester surgical abortion... CONCLUSIONS: Intramuscular ketorolac does not offer superior pain control

Randomized clinical trial evaluating transdermal Ibuprofen for moderate to severe knee osteoarthritis. [2013]
pain management practices... CONCLUSIONS: The use of transdermal VALE-ibuprofen has beneficial clinical

Diclofenac with or without an antiemetic for acute migraine headaches in adults. [2013]
CONCLUSIONS: Oral diclofenac potassium 50 mg is an effective treatment

Randomized comparison between the combination of acetaminophen and ibuprofen and each constituent alone for analgesia following tonsillectomy in children. [2013]
individual constituents for analgesia following tonsillectomy in children... CONCLUSION: The combination of ibuprofen and acetaminophen was not superior to

more studies >>

Clinical Trials Related to Motrin (Ibuprofen)

Efficacy Study of IV Ibuprofen vs IV Acetaminophen Post Surgical Extraction [Recruiting]
This study will compare how effective a single dose of an intravenous (IV) ibuprofen is when compared to single dose of IV acetaminophen in reducing pain. We will administer this study medication thirty minutes prior to removal of wisdom teeth. We want to see if administering these drugs prior to surgery may reduce post-operative pain. Administration of nonsteroidal anti-inflammatory drug before the onset of inflammation during surgery will reduce postoperative pain following third molar extraction when compared to the acetaminophen group. Subjects receiving nonsteroidal anti-inflammatory drug will consume less opioid medications compared to those receiving preemptive acetaminophen.

Oral Ibuprofen Prophylaxis for Patent Ductus Arterioses in Very Extremely Low Birth Weight Infants [Recruiting]
Patent ductus arterioses (PDA) is a major morbidity in preterm infants, especially in extremely premature infants less than 28 weeks. The clinical signs and symptoms of PDA in preterm infants are non specific and insensitive for making an early diagnosis of significant ductal shunting. Functional echocardiography is emerging as a new valuable bedside tool for early diagnosis of hemodynamically significant ductus, even though there are no universally accepted criteria for grading the hemodynamic significance. Echocardiography has also been used for early targeted treatment of ductus arterioses, though the long term benefits of such strategy are debatable. The biomarkers like BNP and N- terminal pro-BNP are currently under research as diagnostic marker of PDA. The primary mode of treatment for PDA is pharmacological closure using cyclo-oxygenase inhibitors with closure rate of 70-80%. Oral ibuprofen is emerging as a better alternative especially in Indian scenario where parenteral preparations of indomethacin are unavailable and side effects are comparatively lesser. Though pharmacological closure of PDA is an established treatment modality, there is still lack of evidence for long term benefits of such therapy as well as there is some evidence for the possible adverse effects like increased ROP and BPD rates, especially if treated prophylactically. The aim of this study is to investigate the effect of oral ibuprofen prophylaxis administrated on the first 24 hours of life and the following two days on hemodynamically significant patent ductus arterioses and its long term effects such as ROP and BPD.

Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production [Completed]
The purpose of this study is to determine whether paracetamol, ibuprofen or their combination can modify generation of radical oxygen species (ROS) from stimulated neutrophils.

Early Versus Late Use of Ibuprofen for PDA Closure [Terminated]
The primary objective is to evaluate the PDA closure rate of early vs. late use of Ibuprofen (Ibu). The investigators believe that early use of Ibu will have a higher PDA closure rate than later use of Ibu. Early use is defined as medication given before the infant reaches 96 hrs old. Late use is defined as medication given when infant is more than 96 hrs old. The secondary objective is to measure the stress hormone and metabolic response (plasma catecholamines, glucose, and lactate) of neonates undergoing Ibu treatment of the PDA. The investigators believe that early ibuprofen will blunt the stress response greater than later use.

Safety Study of Ibuprofen to Treat Acute Traumatic Spinal Cord Injury [Recruiting]

The Ibuprofen - Spinal Cord Injury (SCI) - Safety trial investigates tolerability and

feasibility of "small molecule" (Ibuprofen) mediated Rho-inhibition as putative neuroprotective, plasticity-enhancing and neurorestaurative intervention. The primary safety analysis is based on the incidence of severe gastrointestinal bleedings. In addition, the feasibility of recruitment procedure, and oral administration of the compound within the multidisciplinary setting of acute intensive medical care will be explored. Furthermore, the pharmacokinetics of Ibuprofen under the condition of acute motor complete SCI will be investigated. Secondary endpoints will permit preliminary statements about effects on neuropathic pain, spasticity, and neurological function.

more trials >>

Reports of Suspected Motrin (Ibuprofen) Side Effects

Drug Ineffective (27),  Vomiting (20),  Nausea (20),  Drug Hypersensitivity (18),  Anxiety (18),  Fatigue (16),  Toxic Epidermal Necrolysis (16),  Blood Glucose Increased (15),  Abasia (13),  Pain (13), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Motrin review by 21 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		menstrual cramps
Dosage & duration:		2 tablets a day- morning and night taken twice a day. in the morning and night for the period of 34 days every month
Other conditions:		Ihave sinus but the pill does not have any side effects so it is advisable to take it to control men
Other drugs taken:		nothing else
		Reported Results
Benefits:		I was relieved of menstrual cramps within 15 minutes of taking the pill and during nighttime i was able to sleep peacefully without any pain.I was able to carry out my routine work
Side effects:		There are absolutely no side effects
Comments:		it is advisable to take the tablet after breakfast and after dinner so that makes it twice a day but only for 4 days

Motrin review by 58 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		arthritis pain, neck injury
Dosage & duration:		800mg taken three times a day for the period of daily
Other conditions:		hypertension
Other drugs taken:		baclofen
		Reported Results
Benefits:		decreased pain and inflamation, need no other pain medication for arthritis pain, have bee taking motrin for eight years with good results and little side effects other than mild nausea when taken without food.
Side effects:		motrin has caused mild nausea when taken without food and or milk. when taken after meals it did not cause any nausea, i have not noticed any other side effect.
Comments:		take motrin 800mg, 1 three times a day as needed for arthritis pain

Motrin review by 38 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		flu
Dosage & duration:		max daily dose on packet (dosage frequency: each day) for the period of 3 days
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		significant reduction of pain due to the flu virus. this is a typical prescription for the flu, pain killers with lots of fluids. I was drawn to this tablets because they look appealing, the red capsules are easy to take and the caplets are coated in sugar. Normally I'd take paracetamol, which are dry and hard to swallow, I choose these to be kind to myself !!! I had no idea they could cause this reaction. they were good pain killers.
Side effects:		asthmatic condition. Heavy chest, dry cough, weakness, cumulative effect over days. Still prone to shortness of breath and tightness and heavy chest feelings, very sensitive to sulphides in wine and vinegars etc, was not before this. I only became aware of this connection when I took some I had left for a period pain, once again within seconds I was really ill.
Comments:		Not sure what this section requires ? It's a straight forward case of pain relief in response to the flu virus. the symptoms and the side effects became inter-twined, so it was not apparent that this drug was causing a reaction and worse than that I continued taking it as I became more and more ill. This is an over the counter drug, I would have appreciated more information from my pharmacist. I have tried to tell as many people as possible about what happened. After I have stopped taking the treatment I am left with a susceptibility to asthmatic type symptoms, it was also scary as I instinctively knew I was getting worse and became concerned something very serious was going on. I have never experience that type of "illness" before, normally I take time out and get well... this was an eye-opener.